Antitubercular drugs
EVALUATION OF EFFECT OF ETHANOLIC EXTRACT OF PHYLLANTHUS DEBILIS ON ANTITUBERCULAR DRUGS INDUCED HEPATOTOXICITY IN WISTAR RATS
... line antitubercular drugs like pyrazinamide, isoniazid and rifampin is hepatic ...on antitubercular drugs induced toxicity in wistar ...
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HEPATOPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF CURCUMA LONGA LINN ON ANTITUBERCULAR DRUGS INDUCED HEPATOTOXICITY IN ALBINO RATS
... Objective: The aim of this study was to screen the hepatoprotective effect of ethanolic extract of Curcuma longa on antitubercular drugs induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced ...
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“A Review on Management of Common ADRS of Antitubercular Drugs” by Charumathi A, Suganthi S, Sathish Kumar R, Babisha J, Sankar C, India.
... other drugs the antitubercular drugs also has many adverse reactions which is also a influencing factor of adherence towards the antitubercular ...of antitubercular drugs are ...
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Tuberculosis: History, Epidemiology, Antitubercular Drugs and Plant-based Alternatives
... Oral drugs (para-aminosalicylic acid, cycloserine, terizidone, ethionamide, prothionamide) Third-line 5 Drugs with unclear efficacy or undefined role (clofazimine, linezolid, amoxicillin plus clavulanate, ...
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Development and Validation of a RP-HPLC Method for Simultaneous Estimation of Antitubercular Drugs in Solid Lipid Nanoparticles
... A new simple, rapid and sensitive reversed-phase high-performance liquid chromatography method was developed and validated as per International Conference on Harmonization guidelines, Q2 (R1), for simultaneous estimation ...
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A Study on Adverse Drug Reactions to first line Antitubercular Drugs in DOTS Therapy
... system, liver and biliary system is the most fre- quent organ system affected by ADRs. Multi- ple drug therapy was noticed to be a major pre- disposing factor for developing GI problem. Itching was developed by majority ...
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Mini Review Study of Antitubercular Drugs of Nicotinamide, Thioisonicotinamide and Pyrazinamide Derivatives
... One of the design strategies for new anti-TB agents is based on the improvement of analogs of first-line and/or second line anti-TB drugs. The strategies used and explore structure-activity relationships (SAR), ...
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MEDICINAL CHEMISTRY AND DEVELOPMENT OF ANTITUBERCULAR DRUGS
... Extensively Drug Resistant Tuberculosis (XDR- TB): XDR-TB, defined as extensively drug-resistant tuberculosis are cases of TB disease in persons whose M. tuberculosis isolates were resistant to isoniazid and rifampin and ...
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Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study
... anti-TB drugs as well as the anti-TGF- β 1 siRNA ...anti-TB drugs that may improve the therapeutic effect and reduce the side effects in clinical ...
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LUNG TARGETING OF ANTITUBERCULAR DRUGS BY MICROSPHERE: A REVIEW
... of drugs to the lung vasculature might be promoted by the use of antibodies that interact with receptors expressed preferentially on pulmonary vascular endothelial cells, particularly in certain lung diseases or ...
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Protective potential of royal jelly against hepatotoxicity
... RJ (50 mg/kg) along with antitubercular drugs in Group III significantly (P < 0.05) reversed the levels of serum ALT, AST, total protein, and serum bilirubin as compared to treatment Group II (Table 2). ...
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Prevention of Oxidative Stress Caused by Anti- tubercular Drugs Using Aqueous Extracts of Daucus carota and Moringa oleifera
... Being an excellent source of nutrients, minerals, vitamins, etc moringa has been described as a nutritional dynamite. The combination of antioxidant enzymes and phytochemicals found in moringa coupled with the plant’s ...
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Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents
... vitro antitubercular activity against Mycobacterium tuberculosis ...possess antitubercular activity (minimum inhibitory concentration ...the antitubercular activity and druglikeness profile, it may ...
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NANO FORMULATION ANALYSIS: ANALYTICAL METHOD DEVELOPMENT OF ISONIAZID AND SIMULTANEOUS ESTIMATION OF ANTI TUBERCULAR DRUGS ISONIAZID AND RIFAMPICIN BY RP HPLC
... Results: INH eluted with a short retention time (RT) of 4.06 minutes. Method showed good linearity in the range of concentrations 0.01-100 µg/ml. The limit of detection (LOD) and quantification (LOQ) for INH was 0.03 and ...
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Recent Advancement in the Development of Newer Antitubercular Agents: A Review
... frontline drugs requires several months of chemotherapy to eliminate the persistent ...prescribing antitubercular drugs has contributed to the emergence of multidrug-resistant (MDR), and extensively ...
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Synthesis and Biological Significance of Some 2-Azetidinone Derivatives
... and antitubercular) data revealed that the compounds (4c), (4d), (4e), (4f), (4h), (4i) and (4j) displayed high activity in the series, the compounds (4b) and (4g) showed moderate activity and compound 4a showed ...
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Bedaquiline – A Novel Promising Discovery in Multidrug-Resistant Tuberculosis
... effective drugs and vaccines are ...to drugs used to treat tuberculosis (TB), and particularly multidrug-resistant TB (MDR-TB) has become a significant public health problem in a number of countries ...
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MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING AND ANTIMICROBIAL EVALUATION OF 4 NITROCINNAMIDE ANALOGUES
... antimicrobial, antitubercular, anti-inflammatory, antifungal activity 1 - 5 and are often used as promising precursor for the development of new, highly effective ...as antitubercular, anticancer, ...
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Synthesis, Characterization and Biological Evaluation of 3-Alkyl-5(4-Substituted Benzene Disulphonamido)-1, 2-Benzisoxazoles and its Derivatives
... Synthesized substituted disulphonamide benzisoxazoles and their derivatives are important class of heterocyclic compounds with a diverse medicinal use like antitubercular effect. ACKNOWL[r] ...
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SYNTHESIS OF SOME NOVEL FORMAZANS AS POTENTIAL ANTITUBERCULAR AGENTS
... The Gold Standard of fluorometric tests is the automated system BACTEC MGIT 960™(Becton Dickinson Diagnostic Instrument Systems, Sparks, MD, USA) which was highly sensitive and specific in the detection of ...
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