Antiviral immunity
Long-Lasting Protective Antiviral Immunity Induced by Passive Immunotherapies Requires both Neutralizing and Effector Functions of the Administered Monoclonal Antibody
... The Fc domain of 667 MAb is necessary for healthy survival and efficient mounting of protective immunity in HI-infected/ 667 MAb-treated mice. IgG2a antibodies are endowed with two important effector functions ...
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Overexpression of Cytochrome c by a Recombinant Rabies Virus Attenuates Pathogenicity and Enhances Antiviral Immunity
... an antiviral immune ...stimulating antiviral immunity, we have analyzed these parameters in tissue cultures and in mice infected with a recombinant rabies virus construct that expresses the ...
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Impaired CD8 T cell antiviral immunity following acute spinal cord injury
... Cellular profiling showed upregulation of several immu- nomodulatory pathways (PD-1/PD-L1, Tregs) in the spleen of injured mice (Fig. 5). Although the mechanism of how PD1 and Tregs are induced following SCI is still ...
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MicroRNAs of Epstein-Barr Virus Control Innate and Adaptive Antiviral Immunity
... Innate immune responses form the first line of defense against infectious agents, but viral miRNAs target several cellular transcripts in this pathway to escape immediate detection (Fig. 1). Type I interferons (IFN), ...
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Commensal Bacterial Communities Regulate Antiviral Immunity
... Impaired antiviral immunity was characterized by diminished induction of antiviral defense genes by alveolar macrophages, fewer virus-specific CD8 T cells, reduced circulating viral-specific ...
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Functions and Implications of Circular RNAs in Antiviral Immunity
... in antiviral immunity which will be of great rev- olution to the field of virology as it will both increase our knowledge on the viral life cycle and help in designing effective therapeutic strategies ...
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Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity
... Antiviral immunity in the model organism Drosophila melanogaster involves the broadly active intrinsic mechanism of RNA interference (RNAi) and virus-specific inducible ...in antiviral ...
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Antiviral Immunity following Smallpox Virus Infection: a Case-Control Study
... of antiviral immunity in these two groups of smallpox survivors were compared to 60 control subjects with one or more small- pox vaccinations but with no history of smallpox ...infection. Antiviral ...
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hsp70-Dependent Antiviral Immunity against Cytopathic Neuronal Infection by Vesicular Stomatitis Virus
... of antiviral immunity in which hsp70 is released from virus-infected neurons to induce IFN-  in macro- ...hsp70-dependent antiviral immu- nity to fulminant cytopathic neuronal ...
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Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity?
... virus proceeds with replication. The final mechanism may come from studies in human cellular models in which the virus replicates poorly. Astrocytes represent such a model, but other models in which either the IFN ...
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Dendritic Cells Efficiently Induce Protective Antiviral Immunity
... Knowledge about peptide turnover and its influence on priming efficiency is particularly important for peptide- and cell-based vaccination strategies. During maturation, DC ac- quire the ability to present MHC class ...
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CD4+ and CD8+ T cell–dependent antiviral immunity requires STIM1 and STIM2
... and STIM2 has important implications for the development of CRAC channel inhibitors as therapeutics for the treatment of autoimmune diseases, inflammation, and cancer. Our findings caution that CRAC channel inhibition ...
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Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity
... adaptive immunity are severely com- promised [6–8] and can persist into the chronic phase [4, ...on antiviral immunity using a clinically relevant respiratory virus infection ...robust ...
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Evasion and Subversion of Interferon-Mediated Antiviral Immunity by Kaposi's Sarcoma-Associated Herpesvirus: an Overview
... ticipation of the IFN-induced IRF-7 (48, 49). Thus, by influ- encing both the initial and late phases of type I IFN secretion, IRF-7 emerged as the master regulator controlling type I IFN- mediated innate immune ...
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Evasion of Antiviral Immunity through Sequestering of TBK1/IKKε/IRF3 into Viral Inclusion Bodies
... Various mechanisms are employed by viruses to evade host antiviral strategies. Viral proteins, accessory and nonstructural proteins in particular, function in many viruses to suppress host innate immunity ...
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Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS
... Type I interferons (IFN-Is) provide one of the body’s pri- mary defense systems against viral infections. The high susceptibility of type I IFN receptor (IFNAR)-deficient mice to infection by a variety of viruses ...
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T Lymphocytes Contribute to Antiviral Immunity and Pathogenesis in Experimental Human Metapneumovirus Infection
... To further investigate the role of T cells in hMPV reinfection, we used a second protocol in which mice were treated with antibodies to deplete T-cell subsets until the time of viral cha[r] ...
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RNA interference: the role in antiviral immunity and immune memory
... consequently potentiates cutting a viral RNA by aid of Argonaute protein, ultimately inhibiting translation and/or RNA deadenyaltion (27, 28). When re-infected RISC system is readily alert to degrade viral RNA or to ...
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Human β defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen specific immunity
... adaptive immunity by acting as an adjuvant receptor for Ab production, either directly or by enhan- cing the production of defensins [32, 33] or other immu- nostimulatory ...
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Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice
... protective immunity induced, and assessed different dose combinations of 1Z105 and 1V270 for additive effects to reduce toxicity by minimizing the adjuvant concentrations needed to provide complete ...
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