Apical membrane antigen 1
Population genetic structure and natural selection of Plasmodium falciparum apical membrane antigen 1 in Myanmar isolates
... Apical membrane antigen-1 (AMA-1) is a 83-kDa type I integral membrane protein that is mainly expressed in the merozoite and sporozoite [7, ...
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Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria exposed population
... falciparum apical membrane antigen 1 (PfAMA1), a type 1 integral membrane protein expressed in the merozoite and sporozoite stages of the parasite and a leading candidate for the ...
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Variation in the immune responses against Plasmodium falciparum merozoite surface protein 1 and apical membrane antigen 1 in children residing in the different epidemiological strata of malaria in Cameroon
... kDa apical membrane antigen-1 (AMA-1), on the other hand, is present in both the pre-erythrocytic and asexual blood-stage forms of the Plasmodium ...
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Limited genetic variability of Cytauxzoon felis apical membrane antigen 1 (ama1) from domestic cats and bobcats
... Background: Cytauxzoon felis is a tick-transmitted apicomplexan that causes cytauxzoonosis in domestic cats (Felis catus). Even with intensive care, the mortality rate of acute cytauxzoonosis approaches 40% in domestic ...
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Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1 FVO [25 545]) in healthy Malian adults in Bandiagara
... Apical Membrane Antigen 1 is an extremely polymor- phic protein, with more than 100 polymorphic amino acid sites, and in vitro experiments and studies in both animals and humans have indicated ...
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Sequence diversity and natural selection at domain I of the apical membrane antigen 1 among Indian Plasmodium falciparum populations
... falciparum apical membrane antigen 1 (AMA1) is an 83 kDa membrane protein expressed in the late sch- izont stage of the parasite ...AMA1 antigen have been observed in popula- ...
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Analysis of Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Haplotypes among Iranian Isolates
... vivax apical membrane antigen-1(PvAMA-1) is a surface protein with polymorphic ...this antigen was amplified by Nested-PCR, and ...PvAMA- 1 showed that the amino acid ...
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Population genetic structure of domain I of apical membrane antigen 1 in Plasmodium falciparum isolates from Hazara division of Pakistan
... (MSP-1), apical membrane antigen-1 (AMA1), and thrombospon- din related anonymous protein (TRAP) are reported as vaccine candidate proteins for ...
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Strong Diversifying Selection on Domains of the Plasmodium falciparum Apical Membrane Antigen 1 Gene
... The surface-accessible ectodomain region of the Plasmodium falciparum apical membrane antigen 1 (AMA1) is a malaria vaccine candidate. The amino acid sequence may be under selection from ...
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Temporal genetic changes in Plasmodium vivax apical membrane antigen 1 over 19 years of transmission in southern Mexico
... Background: Mexico advanced to the pre-elimination phase in 2009 due to a significant reduction in malaria cases, and since 2000, Plasmodium vivax is the only species transmitted. During the last two decades, malaria ...
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Allelic Variations of Plasmodium vivax Apical Membrane Antigen-1 (Pv AMA-1) in Malarious Areas of Southeastern Iran Using PCR-RFLP Technique
... vivax apical membrane antigen-1 was amplified using the following primers: Forward (5`- ACCGTTGAGAAGCACGA-3`) and Reverse (5` GATTAGTAGCATCTGCTTGTTCGA- ...sal-1 apical merozoite ...
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Prediction of Merozoite Surface Protein 1 and Apical Membrane Antigen 1 Vaccine Efficacies against Plasmodium chabaudi Malaria Based on Prechallenge Antibody Responses
... Infection with the protozoan parasites Plasmodium falcipa- rum and Plasmodium vivax causes 300 million to 500 million clinical episodes of malaria annually (21). With at least 40% of the world’s population at risk for ...
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Structure of Rhoptry Neck Protein 2 is essential for the interaction in vitro with Apical Membrane Antigen 1 in Plasmodium vivax
... Structural studies by small‑angle X‑ray scattering (SAXS) SAXS experiments were carried out on the SAXS-1 beamline at the Brazilian Synchrotron Light Laboratory (LNLS, Campinas). X-rays energy was 8 keV (l = 1.542 ...
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Natural selection and genetic diversity of domain I of Plasmodium falciparum apical membrane antigen 1 on Bioko Island
... To assess the association between host immune pres- sure and natural selection of PfAMA-1, genetic polymor- phisms in predicted B-cell epitopes and IUR regions were analysed. Based on a recent report, detailed ...
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Comparative analysis of the profiles of IgG subclass specific responses to Plasmodium falciparum apical membrane antigen 1 and merozoite surface protein 1 in naturally exposed individuals living in malaria hypoendemic settings, Iran
... to recognize the native form of both antigens on mero- zoite surface and to determine the similarity between epitopes in recombinant forms and corresponding native proteins. For this purpose, multispot slides of ...
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A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity
... In order to more fully explore pfama1 diversity between geographically divergent malaria endemic regions, haplo- type frequencies were compared at the amino acid level in parasite populations from the DRC and Mali. ...
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Population genetic structure and natural selection of apical membrane antigen 1 in Plasmodium vivax Korean isolates
... this antigen shows a limited antigenic diversity, but most of the major amino acid polymorphisms located on one face of the protein were commonly identified among worldwide ...
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Transcriptome sequencing and analysis of Plasmodium gallinaceum reveals polymorphisms and selection on the apical membrane antigen 1
... were conserved in number and position when the aligned protein sequences of individual domains were analysed, with the exception of domain III. Domain III contains six cysteine residues [71,72], which were present in ...
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Increased sample volume and use of quantitative reverse transcription PCR can improve prediction of liver to blood inoculum size in controlled human malaria infection studies
... and apical membrane antigen 1 (AMA1) administered in combination ...Group 1 immunized with ChAd63- MVA ME-TRAP + CSP ( n = 13 ), Group 2 immunized with ChAd63-MVA ME-TRAP + CSP + AMA1 ( ...
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Acquired Antibodies to Merozoite Antigens in Children from Uganda with Uncomplicated or Severe Plasmodium falciparum Malaria
... 11). Apical membrane antigen 1 (AMA1) is a protein that has been described to be essential for invasion; in comparison to many other merozoite antigens, AMA1 is found in all Plasmodium ...
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