ApoE KO mice
Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice
... from hypercholesterolemic rabbits [6]. As an inhibitor of SPT (the first key enzyme in the SM biosynthetic path- way), myriocin administration dramatically decreased plasma SM levels and atherosclerotic lesions in ...
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Mononuclear cell therapy attenuates atherosclerosis in apoE KO mice
... It is known that the number of circulating EPCs is inversely proportional to the risk of cardiovascular dis- eases [26], suggesting that increasing the number of cir- culating EPCs could be a powerful therapy in the ...
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Original Article Anti-atherosclerosis action of the traditional Korean medicine Bok Ryung Ban Ha -Tang in ApoE KO mice
... in ApoE KO mice. Male ApoE KO mice were fed a high fat diet (western type diet, WD) for 16 ...atherosclerosis mice significantly reduced body weight, liver weight, blood ...
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Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice
... lipidemic mice was significantly increased as compared with that of the wild-type control mice by ...treatment mice decreased by ...hyperlipidemic mice compared with the wild-type control ...
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BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages
... C57BL/6J ApoE KO mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA) and were housed under standard conditions, including humidity, room temperature, and dark–light ...cycles. ...
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Western diet feeding influences gut microbiota profiles in apoE knockout mice
... J mice (wild type, WT) and apoE KO were used and divided into four groups: WT mice feed on normal chow diet (WT-CD), WT mice feed on western diet (WT-HC), apoE −/− mice ...
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APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice
... 5xFAD/ APOE-KO mice compared to E2FAD and E3FAD mice, consistent with an apoE4 loss of ...function. ApoE is also linked to long-term potentiation (LTP) and NMDAR- mediated signaling ...
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Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 68Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques
... of mice, ApoE-KO (n = 15) and control (n = 6), were used for in vivo and ex vivo imaging ...studies. Mice were kept fully sedated with ...of ApoE-KO mice (n = ...
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Alteration of actin dependent signaling pathways associated with membrane microdomains in hyperlipidemia
... the ApoE KO mice (A group) received a hyperlipidemic ...fed ApoE KO mice [39, ...deficient mice), irrespective of the received ...
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The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation
... in mice that brachiocephalic artery GCX degradation correlated to substantial lipid infiltration leading to ath- erosclerotic plaque ...in mice deficient in syndecan-1, a core protein of the ...fed ...
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Anti eotaxin 2 antibodies attenuate the initiation and progression of experimental atherosclerosis
... atherosclerotic ApoE KO mice compared with the younger litters that exhibit only initial fatty ...younger mice, the anti- bodies mainly reduced fatty streak accumulation, where- as in the ...
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Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture
... and apoE KO mice were grown for 8 days in growth media, fixed with 4% para- formaldehyde, and cultures were immunostained for tubulin III (neuronal marker) as described ...versus apoE ...
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Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway
... Male ApoE-KO mice established on a C57BL/6 genetic background (7 weeks-old; 18 – 20 g) were purchased from the Medical Research Center of Peking University (Beijing, ...The mice were housed in ...
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Original Article Rosuvastatin attenuates the progression of atherosclerotic plaque formation in ApoE mice
... 20-week-old ApoE KO mice developed severe atherosclerotic plaque lesion ranging from the ascending aorta to the aortic arch after 8 weeks of fed high fat diet (Figure ...
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T Cells Contribute to Disease Severity during Coxsackievirus B4 Infection
... male mice (23, ...male mice is influenced by the ...of mice (Table 1). Infected mice were monitored daily. If mice became moribund (displayed weight loss, shiver- ing, huddling, and ...
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Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide
... old apoE -/- mice received a single systemic administration of Ang-2 adenovirus (AdAng-2; ...All mice developed atherosclerotic lesions along the proximal aortic wall and at the valve ...
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Insulin decreases atherosclerosis by inducing endothelin receptor B expression
... hyperinsulinemia and increased NO production. It is possible that small reductions in BP may not have been evident using the tail-cuff method in the mice or that downstream NO actions could be inhibited insulin ...
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Vulnerability or resilience of motopsin knockout mice to maternal separation stress depending on adulthood behaviors
... Subject mice were randomly separated into two groups at postnatal day (P) ...(3–5 mice/cage) of same sex ...MS mice were individually housed for 2 weeks before behav- ioral tests were started at 14 ...
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Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression
... APP-KO mice [14,15,64], which we had previously shown to be rescued in APPsα-KI mice ...transgenic mice with mod- erate overexpression of human WT APP [65], or indirect up-regulation of APPsα ...
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Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
... diseased mice, specific staining with this anti-idiotypic reagent was also demonstrated, although the extent of T15 immunostaining varied in different atherosclerotic lesions (not ...
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