apolipoprotein AI
Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene
... human apolipoprotein AI (apoAI), relative apoAI synthesis was measured from endoscopic biopsy samples obtained from 18 healthy ...the apolipoprotein CIII gene transcriptional start site (+ 1): (-641 ...
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Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels
... and apolipoprotein AI/CIII/AIV accounted for 25 and 22%, respectively, of the total interindividual variation in plasma HDL-C ...the apolipoprotein AI/CIII/AIV gene ...
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Apolipoprotein AI transgene corrects apolipoprotein E deficiency induced atherosclerosis in mice
... human apolipoprotein AI (apo AI) transgene in this genetic ...apo AI and HDL are also effective in minimizing apo E deficiency--induced atherosclerosis, we introduced the human apo AI ...
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Familial apolipoprotein AI and apolipoprotein CIII deficiency Subclass distribution, composition, and morphology of lipoproteins in a disorder associated with premature atherosclerosis
... with apolipoprotein AI (apo AI) and apolipoprotein CIII (apo CIII) deficiency were characterized and compared with those of healthy, age- and sex-matched ...
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Relationship between the Apolipoprotein AI, B gene polymorphism and the risk of non-traumatic osteonecrosis
... Apo AI is the major component of high-density lipoprotein protein which can regulate the high-density lipoprotein metabolism and cholesterol transport in plasma via regulating enzyme activity, receptor activity ...
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Polymorphisms at the 5' end of the apolipoprotein AI gene and severity of coronary artery disease
... apo AI are associated with decreased coronary artery disease (CAD) ...apo AI gene, associated in other studies with increased HDL-C, among 644 patients aged < or = 65 years in relation to circulating ...
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Expression of human lecithin cholesterol acyltransferase in transgenic mice Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism
... Human (Hu) lecithin-cholesterol acyltransferase (LCAT) is a key enzyme in the plasma metabolism of cholesterol. To assess the effects of increased plasma levels of LCAT, four lines of transgenic mice were created ...
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Hereditary hepatic and systemic amyloidosis caused by a new deletion/insertion mutation in the apolipoprotein AI gene
... Carriers in the Spanish family studied here also had subnormal plasma levels of both total HDL and of apoAI, and the individual with the lowest plasma concentration of variant compared t[r] ...
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Novel biomarkers predict liver fibrosis in hepatitis C patients: alpha 2 macroglobulin, vitamin D binding protein and apolipoprotein AI
... Conclusions: This study not only reveals three putative biomarkers of liver fibrosis (A2M, VDBP and ApoAI) but also proves the differential expressions of those markers in different sta[r] ...
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Increased prebeta high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes
... In the human apoAI transgenic background, PLTP expression resulted in increased PLTP activity 47%, HDL phospholipid 26%, cholesteryl ester 24%, free cholesterol 37%, and apoAI 22%.. Ther[r] ...
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Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI
... The ability of whole serum to promote cell cholesterol efflux and the relationships between apoprotein and lipoprotein components of human serum efflux have been investigated previously (de la Llera Moya, M., V. Atger, ...
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Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease
... ApoA-I: apolipoprotein AI; ApoC-III: apolipo- protein CIII; CE: cholesteryl ester; CETP: cholesteryl ester transfer protein; CHD: coronary heart disease; CRP: C-reactive protein; CV: coefficient of ...
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Omega-3 fatty acids regulate gene expression levels differently in subjects carrying the PPARα L162V polymorphism
... and apolipoprotein AI (APOA1) were significantly lower for carriers of the PPARa-V162 allele compared to L162 homozygotes after the addition of DHA and a mixture of ...
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Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association
... ApoA-I: Apolipoprotein AI; ARBs: Angiotensin II type 1 receptor blockers; CE: Cholesterol ester; CETP: Cholesteryl ester transfer protein; Cr: Creatinine; DMEM: Dulbecco ’ s modified Eag[r] ...
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Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals
... like apolipoprotein AI and paraoxonase, bound to the HDL-particle ...and apolipoprotein B concentrations in Japanese men and women with coronary heart disease ...
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Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles
... either apolipoprotein AI (apoAI) or apolipoprotein AII (apoAII), the major proteins of HDL, exhibited elevated lev- els of HDL cholesterol, but, whereas the apoAI-transgenic mice were protected ...
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Gene activation regresses atherosclerosis, promotes health, and enhances longevity
... plasma apolipoprotein AI (apo AI) and HDL choles- terol (HDL-C) levels as powerful indicators of a low risk of coronary heart disease (CHD) and cerebrovascular dis- ease [3,4], whereas high apo B and ...
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Plasma fatty acid changes following consumption of dietary oils containing n 3, n 6, and n 9 fatty acids at different proportions: preliminary findings of the Canola Oil Multicenter Intervention Trial (COMIT)
... List of secondary endpoints analyzed in the COMIT study Secondary endpoints ● Cholesterol ● LDL ● HDL ● Triglycerides ● Blood glucose ● Apolipoprotein AI ● Apolipoprotein B ● CRP ● IL-6 [r] ...
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The emerging role of apolipoprotein C-III: beyond effects on triglyceride metabolism
... apolipoprotein B (apoB) or apolipoprotein E (apoE) to hepatic receptors, thus leading to a delayed catabolism of TRL remnants [6]. Third, apoCIII favors the assem- bly and secretion of VLDL in the liver [7, ...
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Serum apolipoprotein C3 levels are negatively associated with hepatitis B virus DNA in HBeAg-negative chronic hepatitis B patients
... 19. Mohamadkhani A, Jazii FR, Sayehmiri K, Jafari-Nejad S, Montaser-Kouhsari L, Poustchi H, Montazeri G. Plasma myeloperoxidase activity and apolipoprotein A-1 expression in chronic hepatitis B patients. Arch Iran ...
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