Apoptosis and ROS
Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer
... triggered ROS formation and reduced the expression of the proliferation markers Ki-67, TOP2A, and TPX2 at mRNA ...in apoptosis; ROS formation was less pro- nounced and the expression of the ...
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Original Article Lovastatin induces apoptosis of HepG-2 cells by activating ROS-dependent mitochondrial and ER stress pathways
... the apoptosis defects are ma- inly determined by a defective balance among pro- and anti-apoptotic members of the Bcl-2 ...cell apoptosis. Besides, we learned from the literature that ROS also ...
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Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling
... cell apoptosis via mitochondrial dependent apoptotic ...and ROS scavengers completely inhibited DSN-induced apoptosis and migration, indicating that ROS play an essential role in GBC ...
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Clomiphene Citrate Induces ROS Mediated Apoptosis in Mammalian Oocytes
... of ROS and thereby apoptosis in granulosa ...cell apoptosis further reduces es- tradiol 17 β level in ovary as well as in ...towards apoptosis, which results in the deterioration of oocyte ...
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Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs
... suppressing apoptosis, and it has been observed that activation of au- tophagy can promote retinal ganglion cell survival and that inhibition of autophagy can reduce cell survival dur- ing optic nerve degeneration ...
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Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death
... of ROS, which is known to be the initiating contributor of ototoxic drugs-induced ototoxicity [36, ...of ROS overwhelms the redox balance, triggering mitochondrial depolarization and release of cytochrome ...
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Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases
... cell apoptosis and ROS production in the rat model ...enhanced ROS production, and triggered cell apoptosis by activating cleaved-caspase ...the apoptosis of cardiomyocytes mediated by ...
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ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells
... induced apoptosis in a concentration-dependent ...induced apoptosis via the Bax/Bcl2 and caspase ...induced apoptosis through the mitochondrial pathway in HaCaT ...of apoptosis and oxidative ...
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Reduced culture temperature attenuates oxidative stress and inflammatory response facilitating expansion and differentiation of adipose-derived stem cells
... Reduced ROS accumulation in 32 °C bone marrow-derived MSC cultures was previously reported ...from ROS overpro- duction and consequential ...prevented apoptosis-induced expansion arrest that was ...
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Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway
... levels, ROS might serve as a second messenger in the signaling pathways of proliferation and differentiation of cells in general and stem cells in par- ticular ...cellular ROS partly promotes proliferation, ...
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Metabolic memory in mitochondrial oxidative damage triggers diabetic retinopathy
... include apoptosis of peripheral blood cells, micro- vascular occlusion, vascular leakage and microaneurysm ...of ROS in cultured RECs, resulting in mitochondrial oxidative damage and ...
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Nanoparticles Induce Oxidative Stress in HT-29 Colon Adenocarcinoma Cell Line After 24 and 48 Hour Exposure
... to ROS and thus have intracellular toxic properties ...via ROS mechanism and mitochondrial damage, and antioxidant applications have been shown to decrease this cytotoxic effect before application ...induce ...
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Intermittent hypoxia from obstructive sleep apnea may cause neuronal impairment and dysfunction in central nervous system: the potential roles played by microglia
... extracellular ROS that are toxic to neurons and the superoxide ...intracellular ROS. This kind of increase in production of ROS is speedy, usually occurring within minutes, and is typically measured ...
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Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and reactive oxygen species generation in A549 and NCI H1299 non small cell lung cancer cells
... In conclusion, CG inhibited the proliferation of A549 and NCI-H1299 NSCLC cells via three specific mecha- nisms (Fig. 9). First, cell cycle arrest was induced in p53- dependent and -independent manners in A549 (p53+/+) ...
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Mitochondrial cytochrome c involvement in programmed cell deathinduced by aluminum stress in Cryptococcus humicola
... with apoptosis, such as nuclear DNA fragmentation, chromatin condensation, production of reactive oxygen species (ROS), decrease in mitochondrion membrane potential (∆Ψm), release of cytochrome c (cyt c) ...
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SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo
... cell apoptosis was markedly inhibited (Figure 7F and Supplementary Figure ...mitochondrial ROS, the dissipation of mitochondrial membrane potential and the reduced intracellular ATP level were markedly ...
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Spinal Cord Injury‚ Oxidative Stress, and Antioxidants: Impact on Male Fertility
... sperm apoptosis in SCI ...and apoptosis (37). “Abortive apoptosis” mechanism occurs in the sperm of infertile men thus the normal clearance of apoptotic marked spermatozoa fails to occur ...and ...
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Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling during Haemophilus parasuis infection
... induced ROS (reactive oxygen species) production, promoted apoptosis, and initiated transcription expression of IL‑6, IL‑8, IL‑10, PGE 2 , COX‑2 and TNF‑α via the NF‑κB signaling pathway, and IL‑1β and ...
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Staurosporine Induced Cell Death in Trypanosoma brucei and the Role of Endonuclease G during Apoptosis
... induce apoptosis even in these ancient organ- isms in different caspase-independent ...of apoptosis like ROS formation, loss of mitochondrial membrane potential, endonuclease G release, ...
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Original Article Lyciumbarbarum polysaccharide pretreatment mitigates cigarette smoke extract -induced oxidative stress in normal human bronchial epithelial cells through regulating Nrf2/Bach1 pathway
... assay. ROS level and apoptosis rate were determined by the means of flow cytometry ...of ROS level in NHBE cells accompanied by inhibition of cell viablity and increase of apoptosis ...
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