Apoptosis and signaling
treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway
... Autophagy, the cellular process that mediates lysosomal degradation of long-lived cytoplasmic proteins, is initiated during periods of differentiation, starvation, or stress, including oxidative stress, endoplasmic ...
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Signaling for survival and apoptosis in the immune system
... of signaling channels initiated by TNF receptor type 1 engagement, which can lead to either cell survival or to cell ...mammalian apoptosis execution machinery, including animals lacking Apaf-1, caspase-3 ...
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Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line
... -catenin signaling pathway and arrest the cell cycle at the G 2 /M phase, we analyzed the effect of Vicenin-2 on the induction of apoptosis and the underlying molecular mechanism (Figure ...of ...
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APOPTOSIS SIGNALING; A DRUG DESIGN IN CANCER THERAPY: A REVIEW
... Pathway: Apoptosis is characterized by cell shrinkage, blebbing of plasma membrane, maintenance of organelle integrity, condensation and fragmentation of DNA, followed by ordered removal of phagocytes 5 ...
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Original Article MiRNA-139 regulates oral cancer Tca8113 cells apoptosis through Akt signaling pathway
... classic signaling pathways on cell apoptosis: the external death receptor mediat- ed signaling pathway and internal mitochondri- al mediated cell apoptosis ...the signaling pathway ...
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Original Article Trichostatin A promotes bladder cancer cell apoptosis and inhibits cell autophagy through MEK/ERK signaling pathway
... by apoptosis and auto- phagy: at the beginning, bladder cancer cells adapted the changes in surrounding by autoph- agy; with the extension of time, cell autophagy was gradually suppressed by the use of high ...
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<p>Inhibition of EGFR Signaling and Activation of Mitochondrial Apoptosis Contribute to Tanshinone IIA-Mediated Tumor Suppression in Non-Small Cell Lung Cancer Cells</p>
... and apoptosis, further con fi rmed that the reduction of Mcl-1 protein level is required for apoptosis induction with Tan IIA ...EGFR-TKIs-induced apoptosis in cancer ...EGFR-Akt signaling, and ...
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So Cheong Ryong Tang induces apoptosis through activation of the intrinsic and extrinsic apoptosis pathways, and inhibition of the PI3K/Akt signaling pathway in non small cell lung cancer A549 cells
... cell apoptosis in vitro ...intrinsic apoptosis pathway. SCRT also activates the extrinsic apoptosis pathway by increasing both TRAIL and FasL, resulting in the activation of caspase-8 and Bid ...
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Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from <em>Cratoxylum arborescens</em>
... Results: Apoptosis was confirmed by the apoptotic cells stained with annexin V and increase in chromatin condensation in nucleus. Treatment of cells with AM promoted cell death-transducing signals that reduced MMP ...
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<em>MSX1</em> induces G0/G1 arrest and apoptosis by suppressing Notch signaling and is frequently methylated in cervical cancer
... Cell Signaling Technology, Boston, MA, USA), Notch1 (#3608; Cell Signaling Tech- nology), Jagged1 (#70109; Cell Signaling Technology), c-Myc (#1472-1; Epitomics, Cambridge, MA, USA), cyclin D1 ...
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Differential Induction of Apoptosis, Interferon Signaling, and Phagocytosis in Macrophages Infected with a Panel of Attenuated and Nonattenuated Poxviruses
... tumors (6, 17, 37). In the present study, we have characterized the infection of macrophages with different poxvirus vectors to gain a better understanding of how these vectors activate specific im- mune responses in ...
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The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration
... externalization (n = 3). Statistical analysis was conducted by paired t-test (***P < 0.001, **P < 0.01, ns – not significant, if P > 0.05). (B) HeLa cells exposed to DMSO, mometasone or guanabenz (1 M) for 4 h ...
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Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen
... Arm signaling, both in the absence of Wg, and within the Wg ...Arm signaling in PRs: DRA fate specification, shortening of PR length, and apoptosis, which are induced by progressively higher levels ...
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Resveratrol and its oligomers : modulation of sphingolipid metabolism and signaling in disease
... 19 metabolic pathways have been elucidated. The neutral building block of all sphingolipids is ceramide that is either formed by de novo synthesis at the endoplasmic reticulum (ER) or activation of sphingomyelinases ...
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NF-κB-Mediated Inhibition of Apoptosis Is Required for Encephalomyocarditis Virus Virulence: a Mechanism of Resistance in p50 Knockout Mice
... FIG. 3. EMCV infection of cells deficient in NF-kB results in an enhanced cytopathic effect and in premature cell death. (A) MEF from wild-type, p50 2/2, and p65 2/2 mice were plated at the same density, infected with ...
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Khz cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase dependent generation of reactive oxygen species in SNU 1 cells
... causes apoptosis in human cancer cells and, if so, to identify the signaling mechanisms ...triggered apoptosis in SNU-1 cells (annexin-V single- positive or annexin-V/PI double-positive cells) as ...
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NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells
... Cellular senescence is a biological process that reflects the cellular response to various kinds of stress including dysfunction of survival-related signaling pathways; these cells enter a long-term state of ...
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Human umbilical cord mesenchymal stem cells implantation accelerates cutaneous wound healing in diabetic rats via the Wnt signaling pathway
... Wnt signaling pathway agonist (Wnt3a) or antagonist (sFRP3) at the edge of the ...Wnt signaling pathway using BrdU staining, CCK-8 assay, live/dead staining, and Western blotting, ...Wnt signaling ...
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<p>PKMYT1 Promotes Gastric Cancer Cell Proliferation and Apoptosis Resistance</p>
... In a study on metastatic renal cell carcinoma, cDNA microarray analysis revealed that PKMYT1 is associated with tumor metastasis. 19 The lentivirus-mediated silencing of PKMYT1 has been shown to effectively inhibit the ...
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Luteolin suppresses gastric cancer progression by reversing epithelial mesenchymal transition via suppression of the Notch signaling pathway
... Notch1 signaling was inhibited by luteolin, and downregulation of Notch1 had similar effects as luteolin treatment on cell proliferation, migration, and ...
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