Application of Mass Spectrometry for Diisocyanate Metabolite
Application of mass spectrometry to the analysis of mixtures
... resolution measurements (7,800), using perfluorokerosine as an internal standard. The resonance electron capture spectra were obtained using ammonia as a buffer gas [r] ...
181
Development and application of capillary electrophoresis/mass spectrometry
... Sequence specific ions were readily produced, resulting in the identification of unknown proteins from sequence database searches in a single analysis. Lee et al.6S demonstrated the advantage of using a fast duty cycle ...
284
Development and Application of Mass Spectrometry-Based Biophysical Approaches
... exchange mass spectrometry (HDX-MS) to understand the calcium dependence of the protein arginine deiminases or peptidylarginine deiminase (PADs), a family of enzymes whose activity is dys-regulated in ...
260
The Application of Protein Mass Spectrometry to the Understanding of Behaviour in Mus Species
... in mass spectrometry analysis, yet provide a reasonable mass difference to differentiate between isotopes for calculation of label ...by mass spectrometric analysis of MUPs expressed in urine, ...
569
The development and application of miniaturised FAIMS combined with mass spectrometry in bioanalysis
... Scanning FAIMS experiments can be carried out by two methods: performing several static LC-FAIMS-MS analyses at fixed CFs that combine to provide a scan, referred to as external stepping of FAIMS conditions, or by rapid ...
185
Application of label free mass spectrometry based proteomics to biomarker discovery
... In a bottom-up proteomic approach as shown schematically in Figure 1. 4, the protein-containing sample is digested enzymatically, chemically or both and the resulting peptides analysed using mass ...
247
Application of Pyrolysis–Gas Chromatography– Mass Spectrometry for the Identification of Polymeric Materials
... -$r($"TJB1BDJàDNovember 2014 16 Structural analysis and the study of degradation properties are important to understand and improve performance characteristics of synthetic polymers and copolymers in many ...
5
Application of Mass Spectrometry Technology to Early Diagnosis of Invasive Fungal Infections
... SATT Nord-de-France, Lille, France a ; Université Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France b ; CHU Lille, Service de Parasitologie-Mycologie, Lille, France c ; ...
12
The application of electrospray ionisation and tandem mass spectrometry to the analysis of polymer additives
... with higher molecular weight require a greater input of internal energy and, therefore, only start to fragment at high values of cone potential. Furthermore, peaks are observed at 32 and 72 Da greater than that of many ...
13
Mass spectrometry-based proteomics techniques and their application in ovarian cancer research
... Human biofluids are usually characterized by high dynamic range, which complicates biomarker discovery process. As tissue samples are poor in proteins but rich in specific mol- ecules related to disease, direct analysis ...
13
Assemblies from Mass Spectrometry: Application to the Yeast eIF3:eIF5 Complex
... The mixture of crosslinked and noncrosslinked peptides was analyzed by nanoLC-MS/MS (see above). Potential crosslinks were identified by using the MassMatrix Database Search Engine (Xu et al., 2010). Raw data were ...
12
Metabolite Identification by Mass Spectrometry
... modern mass spectroscopy techniques have a great impact on quality of metabolite identification ...in mass software and hardware leads to a sensitive and accurate detection of ...of metabolite ...
9
A biplot correlation range for group-wise metabolite selection in mass spectrometry
... Simply speaking, a larger [a j ] m value is associated with more weight for the m th vari- able in new axis a j . In practical use, before the application of dimensionality reduction, one could apply unit variance ...
24
Development of cellular metabolite-based MALDI mass spectrometry assays for drug discovery
... ideas that were repeatedly tested for implementability into a MALDI MS fingerprinting workflow during the course of this thesis. The use of a matrix sprayer, which is used to coat tissue sections with matrix for MSI ...
119
Metabolite-based clustering and visualization of mass spectrometry data using one-dimensional self-organizing maps
... measurements and can be viewed as a noise reduction step. In principle, repeated measurements for averaging are not strictly necessary for application of our clustering approach. In practice, however, the noise ...
18
Advancements in mass spectrometry for biological samples: Protein chemical cross-linking and metabolite analysis of plant tissues
... Tissue samples were cryosectioned as described previously [54] . Briefly, plant tissues were submerged in gelatin and immediately frozen with liquid nitrogen. Transverse plant tissue sections were collected using a ...
144
Spectrometry Mass Spectrometry Ion Mobility pdf
... Although IMS-MS is necessarily a laboratory- based technique, it continues to play a very important part in the understanding of ion-molecule chemistry and the development of IMS equipment that, through user ...
6
Single cell analysis: visualizing pharmaceutical and metabolite uptake in cells with label free 3D mass spectrometry imaging
... of numerous investigated. 26–29 Amiodarone is a cationic amphiphilic drug whose hydrophobic domain allows it to cross the lipid membrane, including that of the lysosome. Inside the acidic environment of the lysosome, ...
21
Development of matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) for plant metabolite analysis
... MALDI-tandem mass spectrometry [22], its application to MS imaging is unique in our multiplex-MSI approach [6] and cannot be achieved by a simple back-to-back ...
136
Advancing metabolomics studies of biological systems using Mass Spectrometry and Mass Spectrometry Imaging
... the application to LMW standards, CHCA and DHB spectra are largely dominated by matrix peaks and 9-AA induces significant fragmentation of phosphorylated ...
195