Aquaporin 2
A decrease in aquaporin 2 excretion is associated with bed rest induced high calciuria
... local Aquaporin-2 (AQP2) mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration and reducing calcium ...
5
Nitric oxide and atrial natriuretic factor stimulate cGMP dependent membrane insertion of aquaporin 2 in renal epithelial cells
... In collecting duct principal cells, aquaporin 2 (AQP2) is shuttled from intracellular vesicles to the plasma membrane upon vasopressin (VP) stimulation. VP activates adenylyl cyclase, increases intra- ...
13
Low aquaporin-2 excretion in the nephrotic syndrome: an escape from the vasopressin regulating effect
... Human EIA; Phoenix Pharmaceuticals, Inc., Burlingame, CA, USA) and urinary AQP2 (EIA Kit for aquaporin-2, Collecting duct; USCN Life Science Inc., Houston, TX, USA) were measured using ELISA. Serum sodium, ...
7
Lithium induced downregulation of aquaporin 2 water channel expression in rat kidney medulla
... channel Aquaporin-2 (AQP2) in rat kidney was ...that 2 d of thirsting or 7 d of dDAVP treatment, in the continued presence of lithium, increased AQP2 expression by six- and threefold, respectively, ...
9
Syntaxin 4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin 2 trafficking
... rat aquaporin-2 pro- vided a positive control for collecting ducts, confirming that the collecting duct segments were correctly identified in the ...
9
Upregulation of aquaporin 2 water channel expression in chronic heart failure rat
... CHF. Aquaporin-2 gene 59-flanking region has a cAMP response element (CRE) and it had been postulated that sig- nals via V2 receptors may act on CRE and enhanced expres- sion of AQP2 ...
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Expression of VAMP 2 like protein in kidney collecting duct intracellular vesicles Colocalization with Aquaporin 2 water channels
... regulates Aquaporin-2 (AQP2) water channels in kidney collecting duct cells by vesicular trafficking between intracellular vesicles and the plasma ...and 2 (VAMP1 and 2), are expressed in ...
12
Defective aquaporin 2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones
... Two major forms of hereditary NDI have been identified— a more common X-linked recessive form caused by mutations in the vasopressin V2 receptor (1, 2) and a rare non–X-linked form caused by mutations in the ...
12
Hypokalemia induced downregulation of aquaporin 2 water channel expression in rat kidney medulla and cortex
... Prolonged hypokalemia causes vasopressin-resistant poly- uria. We have recently shown that another cause of severe polyuria, chronic lithium therapy, is associated with de- creased aquaporin-2 (AQP2) water ...
10
An aquaporin 2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex
... Mutations in the aquaporin-2 (AQP2) water channel gene cause autosomal recessive nephrogenic diabetes insipidus (NDI). Here we report the first patient with an autosomal dominant form of NDI, which is ...
11
Two isoforms of aquaporin 2 responsive to hypertonic stress in the bottlenose dolphin
... of aquaporin 2 (AQP2) and its newly found alternatively spliced isoform (alternative AQP2) and the functions of these AQP2 isoforms in the cellular hyperosmotic tolerance in the bottlenose dolphin, Tursiops ...
10
Upregulation of aquaporin 2 water channel expression in pregnant rats
... Recently, aquaporin 2 (AQP2), the vasopressin-sensitive water channel, has been cloned and located in the principal cells of the kidney collecting duct ...
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Targeted silencing of the Aquaporin 2 gene of Rhipicephalus (Boophilus) microplus reduces tick fitness
... Following the detection of RmAQP2 mRNA in unfed lar- vae, engorged nymphs, and guts and salivary glands of partially engorged females, we investigated the presence of RmAQP2 protein in these tick stages and tissues (Fig. ...
12
Abnormal increase in urinary aquaporin-2 excretion in response to hypertonic saline in essential hypertension
... women, 2) age between 18 and 65 years, 3) arterial hypertension, defined by 24- h ambulatory blood pressure above 125 mmHg systolic or 80 mmHg diastolic, and 4) body mass index (BMI) ≤ 30 kg m -2 ...
15
Rat renal arcade segment expresses vasopressin regulated water channel and vasopressin V2 receptor
... to aquaporin-2 does not recognize aquaporin-2 in the rabbit (unpublished observations) so we are unable to test for the presence of aquaporin-2 in the rabbit ...
10
Role of renal aquaporins in escape from vasopressin induced antidiuresis in rat
... first 2 d before a new steady state level was attained (Table ...day 2 after the initiation of water ...was aquaporin-2 ...day 2 after initiation of water loading and sustained through ...
13
Cytosolic phospholipase A2 regulates Golgi structure and modulates intracellular trafficking of membrane proteins
... A 2 (cPLA 2 ) in membrane-protein trafficking in kidney epithelial ...cPLA 2 in LLC-PK 1 kidney epithelial cells prevents constitutive trafficking to the plasma membrane of an aquaporin ...
12
Expression of matrix Metalloproteinases-2 and aquaporin-1 in corneoscleral junction after angle-closure in rabbits
... into 2 groups, theexperimental group (Group 1) including twenty five rabbits and the control group (Group 2) including 5 ...MMP-2, aquaporin-1, and tissue inhibitors of ...
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A mutagenic approach to elucidating aquaporin function
... insect aquaporin AQPcic was shown to exist in a primarily monomeric state when extracted from yeast and Xenopus oocyte membranes, whereas the wild type was tetrameric [296, ...
292
Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain
... Coded photomicrographs were analysed with ImageJ (v1.45S, NIH). Neurofilament immunoreactivity in the injected hemisphere was quantified as mean staining in- tensity minus background. AnkG and Caspr expression was the ...
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