aqueous solubility
Aqueous Solubility Enhancement of Mirtazapine: Effect of Cosolvent and Surfactant
... of aqueous solubility of mirtazapine could lead to improvement in its bioavailability, reduction in protein binding and half-life and invariably a decrease in its withdrawal ...the solubility of ...
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Evaluation of the effect of compound aqueous solubility in cytochrome P450 inhibition assays
... Turbidimetric solubility assay results indicated that the compound distribution according to their kinetic solubility clearly differed between drug dis- covery compounds and commercial compounds, espe- ...
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Prediction of Melting Point and Aqueous Solubility of Barbiturates
... The UPPER model, which is developed on simple hydrocarbons, is applied to barbiturates. The prediction of properties is directly based on the chemical structure and well-known thermodynamic relationships. It is clear ...
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“ENHANCEMENT OF REPAGLINIDE AQUEOUS SOLUBILITY BY INCLUSION COMPLEX FORMATION WITH CYCLODEXTRINS AND SYNERGISTIC EFFECT OF BASIC pH AND CO-SOLVENT” by Deshmukh Mohammad Rehan, Shaikh Mohammad Sameer, India.
... Figure 1 Chemical structure of repaglinide Cyclodextrins (CDs) are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity and in general they do not permeate lipophilic ...
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ENHANCEMENT OF AQUEOUS SOLUBILITY AND DISSOLUTION OF TELMISARTAN USING SOLID DISPERSION TECHNIQUE
... water solubility and bioavailability of telmisartan by solid dispersion ...saturation solubility studies, in-vitro dissolution study, Fourier-transform infrared spectroscopy, differential scanning ...
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Crystal Engineering of Active Pharmaceutical Ingredients with Low Aqueous Solubility and Bioavailability
... Found in a variety of Asian cuisine, turmeric is a common spice that contains curcumin, a natural drug product that is found to have many health benefits. The use of curcumin in the pharmaceutical and food industries is ...
130
Is experimental data quality the limiting factor in predicting the aqueous solubility of druglike molecules?
... literature solubility data set was compiled from 123 experimental solubility values taken from 12 sources from the ...QSPR solubility data sets; the majority comes from papers on the prediction of ...
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Predicting melting points of organic molecules : applications to aqueous solubility prediction using the General Solubility Equation
... Given that previous work has shown logP to be an important descriptor for solubility prediction, [13, 21] not least suggested in the GSE where logP is a core parameter, melting point predictions were run twice. In ...
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Effect of Cyclodextrin Complexation on the Aqueous Solubility of Diazepam and Nitrazepam: Phase Solubility Analysis, Thermodynamic Properties
... nitrazepam solubility in the presence of various con- centrations of CDs at several temperatures revealed that the solubility of diazepam and nitrazepam increased pro- portionally with an increase in ...
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Solubility prediction of satranidazole in aqueous N,N-dimethylformamide mixtures using extended hildebrand solubility approach
... poor aqueous solubility (0.01 mg/ml). The poor aqueous solubility and wettability of satranidazole give rise to difficulties in pharmaceutical formulations meant for oral or parenteral use, ...
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PHYSICOCHEMICAL CHARACTERIZATION OF – CYCLODEXTRIN COMPLEXES OF TAMOXIFEN CITRATE AND PHASE SOLUBILITY STUDIES
... phase solubility diagram for the complex formation between Tamoxifen citrate and α – cyclodextrin in present in ...the aqueous solubility of the drug increases linearly as a function of α – ...
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A review on bio-availability enhancement techniques of poorly soluble drug
... saturation solubility of a substance in water by the addition of organic salts or also non- electrolytes, which must be physiologically compatible for pharmaceutical ...the aqueous solubility of ...
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Development of an Oxcarbazepine Solid Dispersion Using Skimmed Milk to Improve the Solubility and Dissolution Profile
... method. Higher surface free energy and higher surface area enhanced the dissolution rate of drug. The SD mixer showed high amount of dissolution rate as compare to PM. Moreover, presence of carrier prevents aggregation ...
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C6D2709ECF36A1A055DD34987F6BC923 pdf
... In practical extraction systems, the aqueous solubility of the extractant is necessarily very low; organic-to-aqueous distribution coefficients of some common extractants have been deter[r] ...
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Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation
... better solubility and were selected as the most appropriate constituents for various nanoparticulated ...the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to ...
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CO CRYSTALLIZATION A TECHNIQUE FOR SOLUBILITY ENHANCEMENT
... of solubility in case of API with limited aqueous solubility are becoming increasingly prevalent in the research and development ...the solubility includes micronization where reducing the ...
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FORMULATION AND IN VITRO EVALUATION OF GASTRORETENTIVE FLOATING DRUG DELIVERY OF VALSARTAN USING HOT MELT EXTRUSION TECHNIQUE
... the aqueous solubility of valsartan by utilizing hot melt extrusion technique ...The solubility studies of extrudates, showed a significant improvement in aqueous ...the solubility of ...
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“A Short Review on Cyclodextrin Inclusion Complexes: Synthesis, Characterization and Their Applications”
... the aqueous solubility, bioavailability, stability of unstable drugs, reduction of the unwanted side effects and smell or bad taste can also be masked of a drug ...the aqueous exterior into a ...
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The in vivo effects of pharmaceutical excipients on gastrointestinal transit and drug absorption
... One aim of the present in vivo study was to investigate different types of excipients, which are commonly employed to increase the aqueous solubility of therapeutic [r] ...
250
SPECTROPHOTOMETRIC QUANTIFICATION OF ETORICOXIB IN BULK DRUG AND TABLETS USING HYDROTROPIC AGENT
... of solubility studies indicated that an enhancement in aqueous solubility in ...to solubility in distilled water was more than eighteen ...the solubility of the drug was ...on ...
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