ARENE COMPLEXES
Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity
... Figure 8. Schematic diagram showing the portion of the sequence used to monitor inhibition of RNA synthesis by Ru II arene complexes. The arrow indicates the start of the T7 RNA polymerase, which used as ...
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Improved catalytic activity of ruthenium–arene complexes in the reduction of NAD+
... the complexes. The synthesized series of Ru II complexes of the type [(η 6 -arene)Ru(N,N′)(L)], where N,N′ are water soluble mono- sulphonate ethylendiamine ligands, ...
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Photoactivatable organometallic pyridyl ruthenium(II) arene complexes
... the complexes. All the Ru II pyridine complexes follow a relatively similar photochemical L-ligand dissociation mechanism, likely to occur from a series of 3 MC triplet states with dissociative ...
48
Preparation, characterization and conformational variability of [eta]6-Hexaethylbenzene and other arene complexes of ruthenium
... probe arene-Ru ...coordinated arene carbon atoms, it can be seen that there is one resonance at room temperature, which collapses as the temperature is reduced to approximately 0°C, then reappears as six ...
230
Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs
... Ru(II) arene complexes display promising in vitro and in vivo anticancer activity [13] (Figure 2e and ...extended arene as well as specific hydrogen-bonding interactions between the chelating ligand ...
25
Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity
... Osmium complexes are often considered to be relatively inert (a common characteristic of low-spin d 6 metal ions and especially 3 rd row transition ...II arene complexes can adopt very similar three- ...
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Organometallic osmium arene anticancer complexes
... osmium arene complexes have the potential for exploration as anticancer ...hydrophobic arene face amenable to a wide variety of substitutions together with three other variable coordination ...the ...
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The Nature of the True Catalyst in Transfer Hydrogenation with Alcohol Donors Using (arene)2Ru2Cl4(II)/TsDPEN Precursor
... (II) arene complexes augmented with TsDPEN ligand in basic conditions with 2-propanol as a hydrogen donor are ruthenium nanoclusters formed in-situ via reduction in the reaction ...intermediates ...
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Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design
... rganometallic complexes are well known as catalysts for organic chemical reactions, for example, olefin metathesis by Grubbs’ ruthenium carbene complexes 1,2 and asymmetric hydrogenation of ketones by ...
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Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity
... osmium(II) arene complexes with promising cancer cell cytotoxicity ...these complexes have been shown to induce non-repairable damage to DNA by causing a large degree of DNA unwinding ...osmium ...
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Mirror image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity
... tallic arene complexes would also be interesting in terms of elucidating mechanisms of action. Nevertheless, the purifica- tion of chiral osmium isomers is not easily achieved as chiral columns often ...
12
Potent organometallic osmium compounds induce mitochondria mediated apoptosis and S phase cell cycle arrest in A549 non small cell lung cancer cells
... highest after 24 h of exposure. All three compounds accumulate in cell membranes to a large extent, consistent with the rapid promotion of cell death by acting on mitochondrial pathways. Indeed, compound 2 was able to ...
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Aqueous solution chemistry of ruthenium arene anticancer complexes
... -arene complexes is believed to be DNA, particularly guanine residues. 77 Other studies have shown that binding can also occur with enzymes 78 via ruthenation of the imidazole ring of histidine residues. ...
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Design, synthesis and activation of ruthenium arene anticancer complexes
... II arene complexes of the form [(η 6 -arene)Ru(N,N')(L)] 2+ (where N,N' is a chelating ligand and L is a pyridine or a pyridine-derivative), that can selectively photodissociate the monodentate ...
397
Calixarene methylene bisphosphonic acids as promising effectors of biochemical processes
... calix[4] arene С97 with myosin head is accompanied by time variation of calix[4]arene ...calix[4] arene С97 molecule shifts relative to amino acid residue asn 320 by about ...
23
Oxidative addition of aryl electrophiles to a prototypical nickel(0) complex : mechanism and structure/reactivity relationships
... spectroscopically in a recently published study. 18 As all substrates other than the halides provide an oxygen donor ligand, g and A remain invariant across the series, nearly identical with those of the archetypical ...
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Synthesis of enantiomerically pure and racemic benzyl tethered Ru (II)/TsDPEN complexes by direct arene substitution : further complexes and application
... The new complexes (R,R)-11, (R,R)-14 were tested in a wider range of ATH reactions focussing predominantly on acetophenone derivatives (Figure 6). In these reductions (Table 2) typically 1 mol % of catalyst was ...
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Os2 Os4 switch controls DNA knotting and anticancer activity
... treated surface. This suggests a larger negative charge density of DNA-2 with respect to DNA-1 adducts, probably owing to a reduced number of bound molecules of 2 with respect to 1. A cross-sectional height analysis ...
6
Lower rim ferrocenyl substituted calixarenes: new electrochemical sensors for anions
... The respective ferrocene/ferrocenium redox-couples of compounds 6 a calix[4]arene tetra ferrocene amide and 8 a calix[5]arene pentaferrocene amide are shown to be significantly cathodica[r] ...
8
Experimental and Theoretical Study of the Substituted (Η6-Arene)Cr(CO)3 Complexes.
... tricarbonyl complexes were synthesized by refluxing the same amount of moles of chromium hexacarbonyl and appropriate aromatic ligands in aninert solvent for 9 - 48 hours depending on the arene ...The ...
8