Aromatic Amines

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Structure- Activity Relationship (Sar) Of Cyanoethylated  Aromatic Amines

Structure- Activity Relationship (Sar) Of Cyanoethylated Aromatic Amines

Abstract: Two types of aromatic amines were cyanoethylated. The cyano ethylated products were reacted with propylene oxide to give azocomponents: N-acetyl – N – β – hydroxyl propyl, N- β-propylnitrile -1, 3 – phenyl diamine and N- β hydroxypropyl, N- β- propyl nitrile aniline. These products are referred to as Azodin A and Azodin B respectively. When diazotized aromatic amines were coupled to Azodin B, eight dyes were produced, while Azodin A gave two dyes. Various elemental and spectroscopic methods were employed to elucidate the structure and properties of dyes. The UV-visible spectral data revealed that substitution(s) at the meta-position on the benzene rings of the azodyes favoured bathochromic shift more than those at ortho and para positions (dyes 5,9 and10 vs. others).The dyes were used to colour polyester materials and the exhaustion properties were measured. The result revealed that the dyes have good exhaustion and leveling properties and that the cyano ethylated products have no NH 2 group. Structure-activity

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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF FIVE MEMBERED CYCLIC IMIDE DERIVATIVES OF MONO, DI AND TRI SUBSTITUTED AROMATIC AMINES AND NAPTHYL AMINE

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF FIVE MEMBERED CYCLIC IMIDE DERIVATIVES OF MONO, DI AND TRI SUBSTITUTED AROMATIC AMINES AND NAPTHYL AMINE

H NMR spectra were recorded on 400 MHz and 500 MHz by Brucker spectrophotometer. The reaction was monitored by thin layer chromatography which was performed by using pre-coated silica gel aluminium plates with mixture of diethyl ether and ethyl acetate 7:3 proportion. All the compounds 3a-j and 4a-j were synthesized in hours from the corresponding commercial available aromatic amines, succinic anhydride, acetyl chloride and benzene.

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Spectrophotometric Determination of Trace Amount of some Aromatic Amines in Pharmaceutical Formulations, Wastewater and Biological Fluids

Spectrophotometric Determination of Trace Amount of some Aromatic Amines in Pharmaceutical Formulations, Wastewater and Biological Fluids

A simple, accurate, sensitive and rapid method for the determination of some aromatic amines in either the pure form or in pharmaceutical formulation or in biological fluids or in waste water sample is proposed. The method is based on the formation of colored compounds with sodium 1,2-naphthoquinone-4-sulphonate and cetyltrimethyl ammonium bromide in alkaline medium. Beer’s law of colored species is obeyed in the range of concentration of 0.5 – 24 µg ml -1 . The molar

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Health Safety on Plastic Materials that Come into Contact with Food and Children Toys about Migration of Primary Aromatic Amines Examination in IPH- Skopje in Period 01.012013 – 31.12.2013

Health Safety on Plastic Materials that Come into Contact with Food and Children Toys about Migration of Primary Aromatic Amines Examination in IPH- Skopje in Period 01.012013 – 31.12.2013

processes. People can be exposed to PAA using different synthesized products. [8] Exposure to aniline emphasizes the creation of metabolite - phenyl hydroxylamine, which damages the hemoglobin, which is responsible for transporting oxygen in the bloodstream, which damaged protein cannot transport oxygen is put together for aniline and causes methemoglobinemia, which is result of poisoning with aniline. Bladder cancer is also associated with aniline. [9] In industrialized cities of bladder cancer is the fifth in matching and appearance for women is three times less. Lately interest in human exposure to PAAs through their migration from packaging into food is very high. [10] Primary aromatic amines are generated by reaction of the free non-reactive monomers isocyanates with water, which is present in certain foods. If the monomer is soluble in water, then the water will react with isocyanates as a secondary alcohol, where the hydrolysis reaction will occur related volatile compounds that release CO 2 and thereby create primary aromatic amines according

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Aromatic Amines as Corrosion Inhibitors for Zinc in Hydrochloric Acid

Aromatic Amines as Corrosion Inhibitors for Zinc in Hydrochloric Acid

The inhibition of corrosion of zinc in hydrochloric acid by aromatic amines like, aniline, o- toluidine, m- toluidine, p- toluidine and p- chloroaniline has been studied with respect to inhibitor concentration and temperature. The inhibition efficiency of aromatic amines increased as the concentration of the inhibitor increased, while decreased with the increase in concentration of the acid and temperature. Weight loss data at different temperatures was used to determine activation energy. The activation energies in inhibited acid are higher than that in plain acid. For all inhibitors, the heat of adsorption ( ∆ H ads ) and free energy of adsorption are negative. The plot of log ( θ /1- θ ) versus

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Hydrogen bonding in primary aromatic amines

Hydrogen bonding in primary aromatic amines

ship to the difference between the experimental value of i/fi and that predicted by equation 2*4 (Figure 7*2)* Values for a typical 2-amino-aromatic sulphone, a 2-amino sulphide, 2-iodo- aniline, 2-cyono-oniline, 2-amino-1,4-naphthoquinone also fit this relationship# Because of the variety of forces other than hydrogen bonding that can operate between ortho substituents, this degree of correlation is surprising* Amongst the carbonyl compounds, 2-aminohenzophenone and 1-amino ,2-eiethyl-anthraquinon© show significant deviations from the correlation lines* The 2-halogeno-anilines lie to the right «hand side and it is probable that in these cases other ortho effects are more important than the weak hydrogen bond formed* The values for 2-nitro-aniline also lie to the right of the lines suggesting that there is some other effect involved in this case*

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Extraction and Spectrophotometric Determination of Molybdenum with o-Hydroxythiophenols and  Aromatic Amines

Extraction and Spectrophotometric Determination of Molybdenum with o-Hydroxythiophenols and Aromatic Amines

The interaction of molybdenum (VI) with o-hydroxythiophenol derivatives (HTPDs) and aromatic amines (AAs) was studied. The following three HTPDs, which contain different halogen atoms at position 5, were used: 2-hydroxy-5-chlorothiophenol(HCTP), 2-hydroxy-5-bromothiophenol (HBTP), 2-hydroxy-5-iodothiophenol (HITP)]. The examined AAs were aniline (An), N- methylaniline (mAn) and N,N-dimethylaniline (dAn). The obtained ternary complexes have a composition of 1:2:2 {Mo(V):HBTP:AA}.Optimal conditions for their liquid-liquid extraction (LLE) were found: organic solvent (chloroform), pH (4-6), concentration of the reagents ((1.3- 1.5)10 –3 moldm –3 (HTPD) and (1.2-1.5)10 –3 moldm –3 (AA)) and extraction time(colour develops almost immediately after the reagents addition). The absorbance of the extracts is stable for at least 48 hours. The optimum shaking time is 10 min.). Under the optimal conditions, the complexes have absorption maxima ( max ) at 515-538 nm and molar absorptivities ( max ) between

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A Simple and Effective Protocol for One-Pot Diazotization-Iodination of Aromatic Amines by Acidic Ionic Liquid [H-NMP]HSO4 at Room Temperature

A Simple and Effective Protocol for One-Pot Diazotization-Iodination of Aromatic Amines by Acidic Ionic Liquid [H-NMP]HSO4 at Room Temperature

conditions [12]. Direct iodination has some limitations such as weak electrophilicity of molecular iodine [13] and giving a mixture of isomers due to the lack of regioselectivity of this reaction. Replacement of the diazonium group of arenediazonium salts by iodine is one of the usual and effective methods for the preparation of aromatic iodides (the Sandmeyer reaction) [14,15]. The process of diazotization-iodination is usually carried out * To whom correspondence should be addressed.

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Cerium (IV) Ammonium Nitrate (CAN) Mediated Reactions IV  A Highly Efficient Synthesis of N,N’ Diarylsubstituted Formamidines in Water at Ambient Temperature

Cerium (IV) Ammonium Nitrate (CAN) Mediated Reactions IV A Highly Efficient Synthesis of N,N’ Diarylsubstituted Formamidines in Water at Ambient Temperature

- diphenylformimidamide (3a), in moderate yield (60%). Upon duplication of aniline molar ratio the yield was highly improved up to 93%. We also explored the effect of catalyst molar ratio on overall yield. Our investi- gations clearly revealed that addition of (10 mol%) of CAN to the reaction mixture containing 2:1 molar ratios of amine 1 and triethyl- orthoformate (2) in water at ambient temperature was optimal for the formation of the target molecule 3. Finally, irrespective of the aryl substi- tuent, reactions utilizing a variety of aromatic amines took place in reasonable yields (Table 1).

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Abstract. The acylation of both aliphatic and aromatic amines, alcohols and amino alcohols by simultaneous infrared- ultrasound irradiation (SIUI) in solvent-free conditions in short reaction times and with good to excellent yields was achieved. The results obtained with SIUI and for thermal, infrared and ultrasound energy sources are compared. This is the first report regarding to the application of SIUI in acylation reactions.

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COMPARATIVE STUDY OF SYNTHESIZED SCHIFF BASES

COMPARATIVE STUDY OF SYNTHESIZED SCHIFF BASES

The reaction of primary aromatic amines (4- Morpholinoaniline ) with O-Vanillin is found to be catalyzed by lemon juice or Grapes juice or pomegranate juice as natural acid under solvent-free conditions or traditional method to give the corresponding Schiff bases . Compared with Conventional methods, this eco-friendly reaction has many advantages like economical, environmental, mild reaction conditions and simple work-up with high product yields. The synthesized imines were identified by its physical properties, melting point, characterized by IR, NMR and mass spectrometry.

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Chemical Carcinogen and Cancer Risk: An overview

Chemical Carcinogen and Cancer Risk: An overview

The factors responsible for cancer development are classified as exogenous and endogenous [5] . Unhealthy lifestyle habits such as: inhalation of tobacco and related products; the ingestion of certain foods and their contamination by mycotoxins; are responsible for higher incidences of certain types of neoplasias in a number of population groups [5]. Carcinogens may increase the risk of cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with biological processes, and induces the uncontrolled, malignant division, ultimately leading to the formation of tumors [6]. Cancer is a leading cause of death worldwide. The disease accounted for 7.4 million deaths (around 13% of all deaths) in 2004 [1] . The transformation from a normal cell into a tumour cell is a multistage process, typically a progression from a pre- cancerous lesion to malignant tumours [6]. Epidemiological studies of cancer incidence demonstrated that the risk of developing cancer varies between population groups and these differences are associated with lifestyle factors and habits. It has been estimated that exposure to environmental chemical carcinogens such as polycyclic aromatic hydrocarbon, aromatic amines, amino azo dyes, N- Nitro compounds, natural carcinogens (aflatoxin βI and asbestos) may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers [7, 8, 9, 10,11 ] .

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Pattern of Kebab Intake as a Potential Carcinogenic Risk Factor in Adults of Kermanshah, Iran: 2015

Pattern of Kebab Intake as a Potential Carcinogenic Risk Factor in Adults of Kermanshah, Iran: 2015

15) Ruan ED, Juárez M, Thacker R, et al. Dietary vitamin E effects on the formation of heterocyclic amines in grilled lean beef. Meat Sci. 2014; 96(2 Pt A):849-53. 16) Cross AJ, Ferrucci LM, Risch A, et al. A large prospective study of meat consumption and colorectal cancer risk: An investigation of potential mechanisms underlying this association. Cancer Res. 2010; 70(6):2406-14.

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Iron Catalyzed Reduction of Nitro Compounds

Iron Catalyzed Reduction of Nitro Compounds

A novel, simple and environmentally friendly method for the reduction of aromatic nitro compounds to amines is reported, by using iron powder in aqueous solutions of 1,3-dioxolane. The reaction is accomplished at neutral pH and proceeds with excellent chemo selectivity and yields. This avoids the use of acids/acidic medium for the reduction of nitro compounds.

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Synthesis and Dyeing Performance of Some New Disperse Dyes Based on Coumarin Moiety

Synthesis and Dyeing Performance of Some New Disperse Dyes Based on Coumarin Moiety

Synthesis of disperse dyes derived from diazotization of 3-(2-amino-thiazol- 4-yl) coumarin and coupled with various tertiary aromatic amines as coupling components. Their dyeing performance as disperse dyes has been assessed on polyester fabric. These dyes were characterized by IR spectra, 1 H-NMR spectra and

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The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat

The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat

This study established a relationship between the relative length of telomeres in peripheral blood mononuclear cells and the frequency of eating red meat. This finding differs from those published by Lee YJ et al. [21] on the impact of dietary patterns on telomere length. This study showed that diet rich with red meat can decrease leuco- cyte telomere length 10 years after receiving diet data. Our participants had had blood samples collected just after filling out food frequency questionnaire. Hence we analyzed the relationship without any time shift. Our study population was a little younger (18–65 vs. 40–69 at baseline) and eating habits differ between Poland and Korea. Similarly to Lee YJ et al., a relationship was ob- served in colonocytes of patients who consume higher amounts of red meat [22] but not in those who ate white meat. As mentioned in the introduction, substances that enter the body along with red meat (lipids, heme iron, N-nitroso compounds) can damage the genetic material. This process is well researched in cells directly related to the digestion of red meat products, in terms particularly of carcinogenesis [23–25] can damage the genetic mater- ial. Cooking, frying and especially grilling generates sub- stances with mutagenic activity: heterocyclic amines (HCA), polycyclic aromatic hydrocarbons (PAH), lipid peroxides, wherein the amount is dependent on the temperature of meat processing [26]. Increased con- sumption of processed meat correlates positively with the likelihood of breast cancer [27, 28] and negatively with leucocyte telomere length [29]. Telomere sequences may also be the site of DNA damage [15]. However, some lipid peroxidation products can reduce the risk of carcinogenesis [30]. Carnosine, a dipeptide found in red meat may have a protective effect on telomeres [31]. There is also a published study indicating the negative influence of diet devoid of meat on health status, espe- cially increased incidence of cancer and mental health disorders [32]. This finding can support the concept of positive effects of red meat on health and is also consist- ent with the results of our study. The positive relation- ship between diet rich in red meat and the occurrence of tumors of distant organs from the digestive tract may be due to activity of red meat derivatives in the whole body. Peripheral blood mononuclear cells seem to be a good material for the analysis of the impact of red meat deriv- atives on the body. They are easy to isolate and count. They circulate all over the body and are exposed to the nutrient. Analysis of genetic material derived from these cells allows detection of factors that can influence changes in the genome of other tissues [33].

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Synthesis, Reactivity Studies and Cytotoxicity of Two Iodidoplatinum(II) Complexes. Does Photoactivation Work?

Synthesis, Reactivity Studies and Cytotoxicity of Two Iodidoplatinum(II) Complexes. Does Photoactivation Work?

Following these results, we extended the studies to include the reactivity of trans diiodido diamine platinum(II) with different aliphatic amines.[6] These reactivity studies revealed a very similar profile for the cis and trans complexes upon binding to model nucleobases (DNA). The adduct formation occurs with retention of the amine spectator ligands. Additionally, trans-type complexes manifested a lower propensity to form adducts with peptide and a more classical reactivity, the iodido ligands release upon protein binding. Besides, these last trans series seemed to be affected by the size of the amine ligands showing differences in their reactivity versus S-donor models and in their cytotoxic activity.[6] The reconsideration of these iodido derivatives have shown a great impact in the field, and the trend and behavior of these complexes is being reevaluated.[7]

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“Synthesis of Mannich Bases of Thiosemicarbazide as Mutual Prodrug and In-Vitro Screening for Anti-Infective Activity” by Sachin A Pishawikar, Harinath N More, India.

“Synthesis of Mannich Bases of Thiosemicarbazide as Mutual Prodrug and In-Vitro Screening for Anti-Infective Activity” by Sachin A Pishawikar, Harinath N More, India.

Mannich bases and thiosemicarbazide individually show varied pharmacological activities like anticancer, antimicrobial, antifungal, anticonvulsant, antimalarial, analgesic and anti-inflammatory. By using mutual prodrug concept, first mannich bases were synthesized using aldehyde, ketones and secondary amines with aliphatic, aromatic, cyclic and heterocyclic nature using mannich reaction and then condensed with thiosemicarbazide to form mannich bases of thiosemicarbazide as mutual prodrug. Structural characterization of synthesized compounds was done using IR and H-NMR. Complexicity in the structure of reactants lead to change in reaction time, temperature and % yield of final product. The compounds were screened for anti- microbial activity using Escherichia Coli (8739) Staphylococcus aureus (25923), anti-fungal activity using Aspergillus niger (16404), Candida albicans (10231) using BHI (brain heart infusion) broth dilution method and anti tubercular activity by micro plate Alamar Blue assay (MABA). Keywords: Prodrug, antifungal, antimicrobial, brain heart infusion, mannich bases, thiosemicarbazide

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“FTIR Spectroscopic Screening of Phytochemicals of Two Medicinally Important Species of Solanum used in Preparation of Dashmula Formulation” by Charushila Dalavi, Swaroopa Patil, India.

“FTIR Spectroscopic Screening of Phytochemicals of Two Medicinally Important Species of Solanum used in Preparation of Dashmula Formulation” by Charushila Dalavi, Swaroopa Patil, India.

1042.34,  983.518,  871.667,  762.709  and  669.178  cm ‐1   indicated  alkyl  halides,  aliphatic  aminesaromatic  compounds,  halogen,  and  chloride.  In  case  of  dry  leaf  extract,  the  peak  observed  at  3375.78  cm ‐1   showed  amines  and  amides;  and  at  2924.52  cm ‐1   indicated  alkanes. The band at 1716.34 cm ‐1  signified the presence  of  Carboxylic  acid  and  esters.  Peaks  at  1646.91,  1625.7  and  1613.16  cm ‐1   described  that  those  were  of  amino  acids.  Peaks  at  1582.31  and  1558.2  cm ‐1   showed  nitro  compounds.  Alkanes  are  represented  by  the  peaks  present  at  1495.53,  1455.03,  1411.64,  1368.25  and  1314.25  cm ‐1 .  The  peaks  at  1233.25  and  1211.08  cm ‐1   demonstrated  fluorides.  Remaining  peaks  observed  at  1171.54,  1042.34,  983.518,  871.667,  762.709  and  669.178  cm ‐1   represented  aliphatic  aminesaromatic  compounds and halogen. 

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catalytic hydroamination alkynes pdf

catalytic hydroamination alkynes pdf

The direct addition of ammonia or primary and secondary amines to non-activated alkenes and alkynes is potentially the most efficient approach towards the synthesis of higher substituted nitrogen-containing products. It represents the most atom economic process for the formation of amines, enamines and imines, which are important bulk and fine chemicals or building blocks in organic synthesis. While the hydroamination of alkenes is still limited to more or less activated alkenes, great progress has been achieved in the case of alkynes over the last three years. To illustrate this progress, the review will mostly focus on recent develop- ments in the field of intermolecular hydroamination of alkynes. However, if it is necessary for the discussion, older results and intramolecular reactions, which can be achieved more easily, will be mentioned as well.

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