Arterial smooth muscle
The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell
... Background: Isoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/ AKT signaling pathway. However, both oxidative stress and activated PI3K/AKT signaling contribute ...
8
Stickel, Diana (2017): Cytosolic and mitochondrial Ca2+ handling in pulmonary arterial smooth muscle and endothelial cells. Dissertation, LMU München: Medizinische Fakultät
... Figure 1.5: Schematic presentation of two hypotheses for TRPC-Orai inter- action. A)The research group of Shmuel Muallem claims that STIM can activate both Orai and TRPCs directly. SOCE mediated by Orai and SOCE by TRPCs ...
154
Hypoxia promotes cell proliferation by modulating E2F1 in chicken pulmonary arterial smooth muscle cells
... All animal care and procedures were in accordance with institutional and international guidelines. Twenty day- old chicken embryo pulmonary arterial smooth muscle cells (PASMCs) were isolated by ...
6
Heparin inhibits the induction of three matrix metalloproteinases (stromelysin, 92 kD gelatinase, and collagenase) in primate arterial smooth muscle cells
... Heparin inhibits the migration and proliferation of arterial smooth muscle cells and modifies the extracellular matrix. These effects may be the result of heparin's effects on proteinases that ...
8
Tissue factor is rapidly induced in arterial smooth muscle after balloon injury
... undetectable by RNA blot hybridization. 2 h after balloon injury TF mRNA levels increased markedly. Return to near baseline levels occurred at 24 h. In situ hybridization with a 35S- labeled antisense rat TF cRNA probe ...
8
An investigation of NAADP dependent Ca²⁺ signalling mechanisms in arterial smooth muscle
... in arterial smooth muscle that the predominant ADP-ribosyl cyclase is associated with the microsomal fraction and not the plasma membrane, nuclear or cytosolic fractions (Wilson, et ...cardiac ...
348
Superoxide mediated modification of low density lipoprotein by arterial smooth muscle cells
... human arterial smooth muscle cells as indicated by superoxide dismutase inhibitable reduction of cytochrome ...monkey smooth muscle cells, while catalase (100 micrograms/ml) and ...
6
Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells
... We have recently demonstrated that the glucocorticoid (GC) dexamethasone was able to prevent and reverse pulmonary vascular remodelling associated with the monocrotaline (MCT) model of pulmonary hypertension [19]. ...
16
Calmodulin stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype
... The diversity among cyclic nucleotide phosphodiesterases provides multiple mechanisms for regulation of cAMP and cGMP in the cardiovascular system. Here we report that a calmodulin-stimulated phosphodiesterase (PDE1C) is ...
12
Modulation of calcium channels in arterial smooth muscle cells by dihydropyridine enantiomers
... The observed dissimilar effects of agonist and antagonist DHPs under steady-state conditions (Figs 1, 3, 5 and 6) may indicate selective binding of agonists to closed avai[r] ...
18
Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture
... malondialdehyde-like oxidation products reactive with thiobarbituric acid. Lipoprotein modification was promoted by micromolar concentrations of iron or copper in the culture medium and was metal ion concentration- and ...
6
Replication of cytomegalovirus in human arterial smooth muscle cells.
... Comparative effects of CMV on smooth muscle and on fibroblast cell cultures of human origin Cell culture Cytopathic effect IMR-90a + SMCb +; Delayed, Time of complete dsrcin CVatgn deteM[r] ...
7
Evidence for a role of collagen synthesis in arterial smooth muscle cell migration
... Although there is abundant collagen in the normal vessel wall, vascular cells are induced to synthesize new collagen shortly after arterial injury. Strauss and co-workers observed increased collagen synthesis 1 wk ...
11
THE EFFECT OF NOR EPINEPHRINE ON THE ELECTROLYTE COMPOSITION OF ARTERIAL SMOOTH MUSCLE
... These electrolyte shifts in arterial wall can best be explained by assuming that nor-epinephrine affects the membrane of the smooth muscle cells allowing for a net loss of potassium and [r] ...
6
The association of neuron-derived orphan receptor 1 with pulmonary vascular remodeling in COPD patients
... , smooth muscle actin, cyclin D1, and NOR1 when compared with those in normoxic ...pulmonary arterial smooth muscle cell proliferation and NOR1 overexpression in ...pulmonary ...
10
HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE AND ATENOLOL AND PHARMACEUTICAL DOSAGE FORM
... decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium ...
5
Assessment of Myogenic Power Expenditure Due to Arterial Wall Smooth Muscle Contraction Based upon the Fractal Nature of Vascular Trees
... vascular smooth muscle contraction (VSMC), which consistently regulates the vascular tone and radius, has not been included in the cost function; this is in contrast with cardiac ventricular energetics [5] ...
14
Alterations in arterial function after high voltage electrical injury
... brachial arterial function occurred that involved the endothelium and smooth muscle, even if the victim did not have ser- ious tissue damage or upper extremity ...cient arterial supply due to ...
6
Transforming growth factor beta activity in sheep lung lymph during the development of pulmonary hypertension
... The structural changes in the arterial walls include increased production of extracellular matrix components and smooth muscle cell hypertrophy, changes that have been similarly induced [r] ...
7
Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome
... Lesion analysis, in situ hybridization, histochemistry, and aortic lipid measurements. At the end of the atherosclerosis studies, tissues (except the aorta) were collected for histology in 4% PFA, following perfusion ...
22