Artesunate-mefloquine
Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children
... of artesunate-mefloquine are readily available and used in Africa; it is desirable to evaluate the effects of both meflo- quine and artesunate mefloquine on gametocyte carriage and sex ...
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Pharmacokinetic interactions between artesunate mefloquine and ritonavir boosted lopinavir in healthy Thai adults
... This was an open-label, three-way, sequential, cross- over, pharmacokinetic study in healthy adult volunteers. Inclusion criteria included: (1) males and non-pregnant females, (2) aged 15–55 years, (3) body weight 40–65 ...
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Failure of artesunate mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia
... and mefloquine is common ...ing artesunate-mefloquine and ...for mefloquine monotherapy led to introduction of artesu- nate-mefloquine combination therapy in 1995 and 2000 [4,5], ...
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Artesunate mefloquine combination therapy in acute Plasmodium falciparum malaria in young children: a field study regarding neurological and neuropsychiatric safety
... of mefloquine combination therapy with artesunate for African children has been published, whereas data for Asian children are available ...of mefloquine is ...of mefloquine and ...
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Population pharmacokinetics of mefloquine, administered as a fixed dose combination of artesunate mefloquine in Indian patients for the treatment of acute uncomplicated Plasmodium falciparum malaria
... with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern ...of artesunate mefloquine versus artemether lumefantrine for the treatment of ...
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Efficacy, safety and tolerability of artesunate mefloquine in the treatment of uncomplicated Plasmodium falciparum malaria in four geographic zones of Nigeria
... namely, artesunate + amodi- aquine and artemether + lumefantrine in 2004 showed adequate clinical and parasitological response (ACPR) of ...of artesunate and mefloquine, manufactured by MEPHA Ltd ...
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The story of artesunate–mefloquine (ASMQ), innovative partnerships in drug development: case study
... of mefloquine API, another change of manufacturer had to be managed very late in development due to a halt in production of artesunate API by the selected sup- ...
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Effect of artesunate mefloquine fixed dose combination in malaria transmission in amazon basin communities
... Fixed-Dose Artesunate-Based Combination Therapies (FACT) Consortium, created by the Drugs for Neglected Diseases initiative (DNDi) and the Special Programme for Research and Training in Tropical Diseases (TDR), ...
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The neurological assessment in young children treated with artesunate monotherapy or artesunate mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria
... or artesunate as mono- therapy or with mefloquine ...of artesunate and mefloquine [28] also failed to find any detrimental artemisinin ...of artesunate and mefloquine given to ...
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Population pharmacokinetics of mefloquine given as a 3 day artesunate–mefloquine in patients with acute uncomplicated Plasmodium falciparum malaria in a multidrug resistant area along the Thai–Myanmar border
... of artesunate and mefloquine consisting of mefloquine for 2 days and artesunate for 3 ...patients. Mefloquine concentrations were quantified in whole blood using high‑performance liquid ...
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Compliance with a three day course of artesunate mefloquine combination and baseline anti malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria
... of artesunate and 7 day course of the combination quinine-tetracycline) ...of artesunate and mefloquine on day 3 (about 24 hours after the last dose of meflo- quine and primaquine on day 2) were ...
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Declining in efficacy of a three day combination regimen of mefloquine artesunate in a multi drug resistance area along the Thai Myanmar border
... A total of 150 Burmese patients (85 males, 65 females) aged between 16 and 50 years with acute uncomplicated falciparum malaria received treatment with the first-line three-day artesunate-mefloquine ...
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Clearance Failure Rates of Plasmodium falciparum after Treatment among Children (6 11 years) in Kisumu East Sub County
... of artesunate-mefloquine that was assumed to be ...between artesunate-mefloquine and generic artemether-lumefaantrine, be influenced by random ...the artesunate-mefloquine arm ...
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Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach
... for artesunate, dihydroartemisinin, artemether, artemisinin, chloro- quine, desethylamodiaquine, quinine, quinidine, lume- fantrine, piperaquine, pyronaridine and ...the artesunate-mefloquine ...
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Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of eighth biannual meeting (September 2015)
... ASMQ: artesunate-mefloquine; DHA-PPQ: dihydroarte- misinin-piperaquine; ERAR: WHO emergency response to artemisinin resist- ance; EIR: entomological inoculation rates; ERG: Evidence Review Group; FSAT: ...
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Challenges for malaria elimination in Brazil
... and mefloquine as the first-line regimen for uncomplicated falciparum malaria in Brazil in the late ...dose artesunate–mefloquine (ASMQ) combination in Juruá Valley, Acre, between July 2006 and ...
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Assessing the utility of an anti malarial pharmacokinetic pharmacodynamic model for aiding drug clinical development
... with artesunate-mefloquine was highly correlated to the in vivo EC50 value of ...of artesunate) compared to mefloquine which remains in the body, on average, for 40 ...
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A randomized trial of artemether lumefantrine versus mefloquine artesunate for the treatment of uncomplicated multi drug resistant Plasmodium falciparum on the western border of Thailand
... found, artesunate-mefloquine combination therapy (MAS3) is the standard treatment regimen for uncompli- cated falciparum malaria ...increasing mefloquine resistance ...
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Mefloquine pharmacokinetics and mefloquine artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria
... of mefloquine (MQ) have been reported to be non-bioequivalent; this could result in sub-therapeutic levels of mefloquine with decreased ...2002, mefloquine-artesunate (MQ-AS) combination ...
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Simultaneous quantification of artesunate and mefloquine in fixed dose combination tablets by multivariate calibration with middle infrared spectroscopy and partial least squares regression
... ARS, MFQ and ARS-MFQ fixed-dose combination tab- lets were provided by Farmanguinhos/Fundação Oswaldo Cruz (Rio de Janeiro, RJ, Brazil). The ARS standard was obtained from Farmacopeia Brasileira (>98.8 %) (Bra- sília, ...
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