Asiatic acid
Original Article Asiatic acid promotes liver fatty acid metabolism in diabetic models
... Abstract: Asiatic acid (AA) has lipid-lowering and anti-diabetic ...fatty acid (FFA)-induced hepatic cell ...fatty acid synthesis and increased expression of genes associated with fatty ...
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Pre infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague Dawley rats
... oleanolic acid (OA) [8] and maslinic acid (MA) [9] have shown amelioration of metabolic dysfunction in ...of asiatic acid (AA) as a potential anti-malarial. Asiatic acid is an ...
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Elicitation effect on the production of asiaticoside and asiatic acid in shoot, callus, and cell suspension culture of Centella asiatica
... brahmoside, asiatic, centellic, brahmic, and madecassic ...are asiatic acid (ATA), asiaticoside, madecassoside, and madecassic acid (Roy and Bharadvaja, 2017b, Kundu et ...
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Asiatic acid attenuates renin angiotensin system activation and improves vascular function in high carbohydrate, high fat diet fed rats
... that asiatic acid attenuated neurogenic-mediated vasoconstriction and plasma NE which could be resulted from the alleviation of plasma insulin in the treated MS ...
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Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway
... Asiatic acid (AA), a natural pentacyclic triterpene de- rived from the medicinal herb Centella asiatica, elicits multiple bioactivities, including antioxidant, anti-apoptotic, and anti-inflammatory ...
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Original Article Asiatic acid attenuates traumatic brain injury via upregulating Nrf2 and HO-1 expression
... Abstract: The neuroprotective role of asiatic acid (AA) against cerebral ischemia has been previously reported. However, whether AA attenuates traumatic brain injury (TBI) has not been investigated. The ...
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Estimation of Asiatic acid, Asiaticoside and Madecassoside in two accessions of Centella asiatica (L) Urban for Morpho-chemotypic variation
... sapogenin asiatic acid were analyzed and quantified by ...of asiatic acid, asiaticoside and madecassoside found in SL accession were ...
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Quantitative Estimation of Asiatic acid, Asiaticoside & Madecassoside in two accessions of Centella asiatica (L) Urban for Morpho-chemotypic variation
... compounds asiatic acid, asiaticoside and madecassoside of known concen- trations were applied to the layers as 6 mm-wide bands positioned 10 mm from the bottom and 15 mm from side of the plate, using Camag ...
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95. Production and quantification of Asiatic acid from in vitro raised shoots and callus cultures of Centella asiatica (L.) Urban
... of asiatic acid has been reported in cancer cell lines via inhibition of cell cycle progression (Ya et ...of asiatic acid has been proved (Byung et ...of asiatic acid under ...
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AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells
... Abstract: Asiatic acid (AA; 2α,3β,23-trihydroxyurs-12-ene-28-oic acid) is widely used for medicinal purposes in many Asian countries due to its various ...
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Asiatic acid protests against myocardial ischemia/reperfusion injury via modulation of glycometabolism in rat cardiomyocyte
... vehicle-, asiatic acid (aa)-, and asiatic acid plus lY294002 (aa+lY)-treated rats under normal condition and following 1 hour of myocardial ischemia and 24 hours of reperfusion, ...
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Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin
... We recently showed that imbalance of TGF-β/Smad signaling with over-activation of Smad3 but lower levels of Smad7 is a central mechanism of tissue fibrosis. In the present study, we report here that inhibition of Smad3 ...
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The effects of individual and combination of asiatic acid and madecassoside derived from Centella asiatica (Linn.) on the viability percentage and morphological changes of mouse macrophage cell lines (J774A.1)
... Asiatic acid and madecassoside are the two pentacyclic triterpenoid compounds derived from Centella asiatica (Linn.), which believed to possess major contribution in many related pharmacological activities. ...
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HPLC method validation for simultaneous estimation of madecassoside, asiaticoside and asiatic acid in Centella asiatica
... validation of an analytical procedure is the process of confirming that the analytical procedure employed for a test of pharmaceutics is suitable for its intended use. In other word, the validation of an analytical ...
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Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway
... Asiatic acid (AA), a chemically characterized pentacyclic triterpene, naturally exists in many edible vegetables and fruits including brown mustard, basil, daylily, hawthorn fruit and spinach ...
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Asiatic Acid Isolated From Centella Asiatica Inhibits TGF-β1-induced Collagen Expression in Human Keloid Fibroblasts via PPAR-γ Activation
... Figure 9. PPAR-γ silencing abrogated the inhibition of asiatic acid (AA) and rosiglitazone (Ros) on collagen type I expression and Smad 2/3 phosphorylation induced by TGF-β1 in keloid fibroblasts. A: Cell ...
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BENIFICIAL EFFECT OF CENTELLA ASIATICA AND ASIATIC ACID IN IMMOBILIZATION INDUCED STRESS IN RATS: A FTIR STUDY
... Fourier transform infrared (FTIR) spectroscopy is considered as an ideal tool for comparative studies. Infrared spectroscopy is a widely used method in biology and pharmacology for analyzing molecular structure and ...
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A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway
... an Asiatic acid (AA) derivative, N-(2α,3β,23-acetoxyurs-12-en-28-oyl)- l -proline methyl ester (AA-PMe), is reported to dose dependently suppress constitutive STAT3 activation in gastric cancer ...3, ...
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Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P berghei infected Sprague–Dawley male rats
... Maslinic acid, a possible multi targeting antimalarial, effectively inhibited proteolytic processing of the merozoite surface protein (MSP1) com- plex, inhibited the metalloproteases and revealed (in silico ...
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PHYSIOLOGY AND ENZYMATIC ACTIVITY OF ASIATIC CARROT SEEDS AS AFFECTED BY INVIGORATION TREATMENTS
... of seed invigoration. In Asiatic carrot, slow and non- uniform seedling emergence is a major problem. This results in smaller plants and production of non-uniform roots of poor marketable value. Hence, various ...
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