AT1 receptor
The angiotensin II AT1 receptor associated protein Arap1 is involved in sepsis induced hypotension
... reduced receptor transcription, translation and/or mem- brane trafficking ...of receptor-associated proteins might be relevant, including the recently discovered angiotensin II AT1 ...
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Memory is preserved in older adults taking AT1 receptor blockers
... block AT1 receptors, allowing greater AT2 receptor binding [32], thus exerting their effects by both interrupting AT1 receptor activity and promoting AT2 receptor ...activity. ...
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AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARγ
... One characteristic of the PPARs is that their activation can occur through a broad spectrum of ligands even with rather low affinity [23]. This implies that particular care must be taken when assessing the ...
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Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction Angiotensin II stimulates the release of vasorelaxants
... the AT1 receptor antagonist losartan competed in a monophasic manner for all the specific binding, suggesting that the non-AT1/non-AT2 recognition site identified using autoradiography may be a ...
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Angiotensin AT1 receptor blockade abolishes the reflex sympatho excitatory response to adenosine
... We tested the hypothesis that endogenous angiotensin II participates in the direct and reflex effects of adenosine on the sympathetic nervous system. Nine healthy men were studied after 1 wk of the angiotensin II type I ...
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Comparative study of interactions of aliskiren and AT1 receptor antagonists with lipid bilayers
... Hypertension is a risk factor associated with cardiovascular diseases, and the first leading cause of death in economically developed countries. For this reason, medicinal chemists aim to synthesize more effective and ...
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Effect of Combined Treatment with AT1 Receptor Antagonists and Tiagabine on Seizures, Memory and Motor Coordination in Mice
... In the current study, the effects of losartan and telmisartan on the anticonvulsant activity of ti- agabine, a second-generation antiepileptic drug, in the MEST test have been evaluated. TGB with anti- convulsant action ...
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Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor
... I-I-N-T-N-I-T-V-C-A-F-H-Y-E-S-Q-N-S-T-L) was added in excess (0.5 µg in 50 µl) to 50 µl of the immunoglobulin frac- tion. The mixtures were shaken and placed in a refrigerator for 1 h. The 100-µl samples were then added ...
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Management of Hypertension and Heart Failure with AT1 Receptor Blockade
... AT2 receptor subtype predominance in LV tissue from rats with pressure overload LV hypertrophy 20 ...ATI receptor levels and signalling in hearts with LV hypertrophy remains to be ...All receptor ...
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Cardiac specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor mediated pressor and chronotropic effects
... In this study, we also found that the increase in MAPK ac- tivity after Ang II infusion was significantly inhibited in the hearts from AT2 TG mice, in agreement with previous obser- vations in cells expressing AT2 such ...
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Dopamine decreases expression of type 1 angiotensin II receptors in renal proximal tubule
... modulates AT1 receptor expression in cultured proximal tubule cells (RPTC) expressing DA1 ...RPTC AT1 receptor mRNA levels by 67 +/- 7% (n = 10; P < ...basal AT1 receptor mRNA ...
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Search | Preprints
... vs AT1 blockers. Hypertensive elderly patients on AT1 receptor blockers would have an inhibited pro- inflammatory pathway, while keeping Ang II levels high (as in children) occupying ACE2 and ...
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Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1
... same receptor. Angiotensin II receptor is of particular interest as a candidate, oestrogen-interacting ...of AT1 receptor stimulates growth factor pathways such as tyrosine kinase phosphoryla- ...
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Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta
... II receptor subtypes AT1 and AT2, and angiotensin-converting enzyme, in the neointima formed in the rat thoracic aorta 15 d after balloon-catheter ...both AT1 and AT2 receptors (80% and 20%, ...
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TELMISARTAN EFFECT IN HYPERTENSION ASSOCIATED WITH DYSLIPIDEMIAAraveti Lokesh, Somana boina Padmakar*, K. Sujan kumar, S. ParveenDOWNLOAD/VIEW
... II RECEPTOR BLOCKERS Angiotensin II receptor antagonists [angiotensin receptor blockers [ARBs]] are widely used clinically as antihypertensive ...
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Renovascular and renoprotective properties of telmisartan: clinical utility
... The importance of blood pressure control as a means to pre- vent development or reduce progression of cardiovascular and kidney diseases has been firmly established. Like other blockers of the AT1 receptor, ...
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THE EFFECT OF TOPICAL ALISKIREN ON OCULAR HYPERTENSION INDUCED BY WATER LOADING IN RABBITS
... angiotensin AT1 receptor antagonist), reduces IOP with a 17% increase in uveoscleral outflow, but without changes in outflow facility and in rates of aqueous humor ...
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Original Article Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells
... Abstract: The use of mesenchymal stem cell (MSC) transplantation for ischemic heart disease has been reported for several years. The main mechanisms responsible for the efficacy of this technique include the ...
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The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats
... AT2 receptor modulates renal production of cyclic guanosine 3',5'- monophosphate (cGMP; ...AT2 receptor to stimulate renal production of nitric oxide leading to the previously observed increase in ...AT2 ...
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The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion
... AT2 receptor has been ascribed a coun- terregulatory function modulating actions by the AT1 re- ...the AT1 receptor prolong the neural sympathoadrenergic in- hibition of mucosal alkaline ...
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