ATP-sensitive K+ channels
Evidence that glucose can control insulin release independently from its action on ATP sensitive K+ channels in mouse B cells
... of ATP-sensitive K+ channels, depolarization, and Ca2+ influx in B ...control ATP-sensitive K+ channels. Opening of these channels by diazoxide (100-250 ...
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Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels?
... ion channels by anionic phospholipids is currently very ...regarding ATP-sensitive K ⫹ channels in smooth muscle, for which there is substantial literature supporting inhibitory ...
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Intracellular ATP can regulate afferent arteriolar tone via ATP sensitive K+ channels in the rabbit
... mM ATP and in a dose-dependent fashion by glibenclamide (10(-9) M to 10(-6) M), a specific antagonist of KATP ...a K+ channel opener, activated these channels in the presence of ATP, and this ...
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Mitochondrial ATP sensitive K+ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heart
... muscle; however, direct evidence of their presence in ectothermic myocardium has yet to be presented. Gamperl et al. (2001) have shown in the in situ rainbow trout Oncorhynchus mykiss heart that a 5 min period of anoxic ...
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ATP-sensitive K(+)-channels in muscle cells: features and physiological role
... транспортувальна пора каналів утворена чотир - ма симетрично розташованими ідентичними субодиницями, всередині яких знаходиться наповнена водою порожнина. У цій порожнині позитивно заряджений іон потрапляє в ото - чення ...
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Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
... potassium channels have been shown to be one of the key regulators of HPV [5], but in candidates like ...contrast, ATP sensitive K-channels (KATP) were demonstrated to be increased in ...
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Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle Implications for ischemia and reperfusion injury
... cellular K+ efflux, shortening of the action potential duration, changes in tension, and depletion of high energy phosphates similar to ischemia and metabolic ...activated ATP-sensitive K+ ...
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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels
... If the sensitivity of the vasorelaxant responses of pinacidil, KB-R6844 and KB- R6907 to the L-arginine and L-ornithine analogues were entirely due to endothelial NO production, then in the absence of a functional ...
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The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection
... scrubbed with Hibiscrub (contains: 4% w /v chlorhexidine gluconate; ZENECA Limited, Macclesfield), and a gown donned. A laparotomy drape was placed over the rabbit's chest to provide a sterile area for working. A m ...
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Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... DAG is not always formed In equal quantities to IP3 and there may be temporal variations In the effects of these second messengers. The main physiological target of DAG Is thought to be a series of phosphatidyl ...
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Kir6.2-containing ATP-sensitive K+ channel is required for cardioprotection of resveratrol in mice
... of K- ATP channels in cardiovascular system is that opening of this channel can protect cardiac myocytes against is- chemic ...injuries. K-ATP channels are present in multiple ...
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K+ATP CHANNELS MODULATE HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL AFTER PRETREATMENT WITH THE K (ATP) OPENER PINACIDIL AND PHOSPHOLIPASE C INHIBITOR ON ETOMIDATE IN THE MICE
... potassium channels are an important class of ionic channels, whose function is regulated by changes in the intracellular level of adenosine triphosphate (ATP) levels are elevated and open, when ...
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Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
... mitochondrial ATP-sensitive K + (mitoK ATP ) channels rather than sarcolemmal K ATP (sarcK ATP ) channels are important as end effectors and/or triggers of ...
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ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
... calcium channels (Ca2+ channels) and ATP-sensitive potassium channels (K+ channels) in hyperalgesia induced by morphine in dia- betic ...
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Expression of ATP-sensitive potassium channels in human pregnant myometrium
... myometrium. Paired US and LS biopsies were obtained from pregnant women at term. The expression level of Kir6.1, Kir6.2, SUR1 and SUR2B were determined by Western blotting as described in Materials and Methods. The ...
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The Self Calibration Method for Multiple Systems at the CHARA Array
... TRP channels are TRPC channel members. There are seven TRPC channels which are grouped into 4 ...TRP channels are non-selective to cations and are highly permeable to Ca 2+ compared to Na + ...ion ...
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Acute simvastatin inhibits K-ATP channels of porcine coronary artery myocytes
... The biochemical existence of cytochrome P450 (CYP450) 3A4 was demonstrated in porcine coronary artery and human left internal mammary artery, and the possible local enzymatic conversion of simvastatin into simvastatin Na ...
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The ATP sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog
... the K+ATP channel, caused vasoconstriction and restoration of blood ...the K+ATP channel in vascular smooth muscle, and anaerobic metabolism with acidosis is a sufficient stimulus for channel ...
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Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231
... potassium channels block- ers and other agents that cause cell membrane depolarization, produce the arrest of cells in G1 phase with the involvement of different cyclins and inhibitors depend- ing on the cell type ...
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Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
... KATP: ATP-sensitive potassium channels; HR: heart rate; STZ: streptozotoxin; CO: cardiac output; i.p.: intraperitoneal; HG: high glucose; PBS: phosphate- buffered saline; BSA: bovine serum albumin; ...
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