Aurora-A
Physiological and Oncogenic Aurora-A Pathway
... the Aurora-A gene is cell-cycle regulated. Thus, the promoters of the Aurora-A gene contain specific elements (CDE/CHR sequences), which are responsible for transcription at G2 phase of the cell cycle ...of ...
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Aurora A contributes to cisplatin resistance and lymphatic metastasis in non small cell lung cancer and predicts poor prognosis
... down Aurora-A expression in A549/DDP and H460/DDP cells by siRNA (Figure 5A, left panel), and found that it resulted in a significantly enhanced sensitivity to cisplatin (Figure 5A, right ...of Aurora-A by ...
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Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway
... distinct. Aurora A (also named Aurora 2, STK15, BTAK, mouse Stk6, or Iak1) was first identified as a human homologue of the Aurora/Ipl1p kinase family, which is located at chromosomal region ...[4]. ...
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Original Article Knockdown of Aurora A suppresses cell proliferation of human gastric cancer cells by inhibiting cell autophagy
... Recently, Aurora A was report- ed to be involved in canonical Wnt signaling in gastric carcinogenesis ...Specifically, Aurora A had a strong correlation with Rac GTPase- activating protein 1 (RACGAP1), a ...
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A Novel Aurora-A Inhibitor, BPR1K0609S1, Sensitizes Colorectal Tumor cells to 5-Fluorofracil (5-FU) Treatment
... Small synthetic compounds have been implicated in treatment of human cancers. We have syn- thesized a small compound, BPR1K0609S1 (hereafter, BP), which inhibits Aurora-A kinase. In the present study, we studied ...
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Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic
... of Aurora-A activation based on our kinetic data and the observation from crystal structures that increased levels of Aurora-A activity are associated with increased order in the activation loop of the ...
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A method for analyzing the ubiquitination and degradation of aurora-A
... 1C1 and 6E3 monoclonal antibodies were directed against pAurora-A (20,21). 1C1 detects both the histidine-tagged and the endogenous aurora-A whereas 6E3 detects only the histidine-tagged protein (20). ...
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Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases
... effectively inhibit VEGF-stimulated HUVEC cells prolif- eration and suppress the tube formation of HUVEC cells. These data indicated that TY-011 was able to antagonize tumor angiogenesis. Therefore, TY-011 exhibited ...
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Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
... with Aurora-A in which N-Myc is trapped in an ordered ...of Aurora-A to induce a conformation that is incompatible with the binding of N-Myc, and early clinical trial data suggest these compounds may ...
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Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma
... cells. Aurora- A is important to centrosome duplication, maturation and accurate separation as well as to bipolar spindle assembly and ...of Aurora-A expression might contribute to the aberrant cell growth ...
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Dictyostelium Aurora Kinase Has Properties of both Aurora A and Aurora B Kinases
... kinases, Aurora A and B, which contribute distinct functions at the spindle poles and the equatorial region ...single Aurora kinase, DdAurora, that displays characteristics of both Aurora A and ...
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Investigating the particle precipitation of a moving cusp aurora using simultaneous observations from the ground and space
... of Aurora B suggests that it takes a few mi- nutes (from 08:22:28 to 08:25:53 UT) for the result of the tension exerted by the reconnected field line to become prominent in the ionosphere after the appearance of ...
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Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells
... of Aurora A and B protein. An Aurora kinase inhibitor, tozasertib (VX-680), inhibited growth, promoted pro-apoptotic activity, reduced the phosphorylation of BCR-ABL and Crk-L, and activated caspase-3 and ...
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Aurora Kinase A and Gastrointestinal Malignancies
... The Aurora A and B (AURKA and B) were originally described as regulators of mitosis in cell cycle studies of model organisms like Xenopuslaevis (African clawed frog) [2-4], Drosophila melanogaster (fruit fly) ...
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Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck
... the Aurora kinases as potential targets in this disease. Aurora kinases are upregulated in multiple human cancers, correlating in some cases with poor prognosis [18, 20-21, ...both Aurora-A and EGFR ...
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Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus
... cycle. Aurora A, by recruiting pericentriolar material (PCM) and interacting with the Ran-TPX2 pathway, is required for the matur- ation of centrosomes and mitotic-spindle assembly re- spectively ...of ...
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Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in Vitro
... R. B. Cohen, E. C. Dees, H. Burris, J. R. Infante, T. Ma- carulla, E. Elez, J. Andreu, E. Rodriguez-Braun, S. Ro- sello, M. von Mehren, N. J. Meropol, C. J. Langer, B. ONeil, D. Bowman, M. Zhang, H. Danaee, L. Faron- ...
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CSN6 deregulation impairs genome integrity in a COP1- dependent pathway
... as Aurora A kinase will be ...including Aurora kinase A, providing explanation to COP1-mediated genome instability and a possible plethora of functions of ...
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Neuroblastoma treatment in the post-genomic era
... The serine/threonine kinases Aurora A (AURKA) and Aurora B (AURKB) are crucial regulators of the cell cycle. Their coding genes differ in subcellular distribution and the protein products in their specific ...
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A real time hybrid aurora alert system:combining citizen science reports with an auroral oval model
... A multitude of aurora visibility alert services already exist, some run by academic or research institutions and some by the interested public. Most of these services rely solely upon measures or, more often, ...
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