Autoimmune response
Autoimmune response to PARP and BRCA1/BRCA2 in cancer
... “Autoimmune response to tumor-associated antigens (TAAs) in the context of synthetic lethality in cancer” was authored by Tan EM, Peng XX and Zhang ...
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Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response
... Our recent novel data suggested that enhanced CNS antigen presentation and lymphocyte activation in the brains of MPSIIIB mice may be a critical contributor to the progression of MPS IIIB[8]. Also, the de novo synthe- ...
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Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?
... Citrullination is thus a widespread phenomenon in normal physiology and infl ammation, although targeting citrullinated proteins for an autoimmune response is relatively restricted to RA as shown by the high ...
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Autoimmune response to transthyretin in juvenile idiopathic arthritis
... T cell responses to TTR protein and peptides. To further analyze the extent of the immune response to TTR, we tested T cell reactivity to the TTR peptides found in the peptidome/degradome of the JIA SF. Four ...
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Proinsulin: a unique autoantigen triggering autoimmune diabetes
... pathogenic autoimmune response to proinsulin subsequently spreads to other antigens (see the related article beginning on page ...immune response in autoimmune ...
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T cell control in autoimmune bullous skin disorders
... Algorithm for HLA class II–Dsg3 peptide interaction in PV. Shown is the physical interaction of DR β 1*0402 with a representative Dsg3 peptide. HLA-DRβ1*0402 differs from other HLA-DR4 molecules by the pres- ence of a ...
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Autoimmunity caused by disruption of central T cell tolerance A murine model of drug induced lupus
... restricted autoimmune response was induced by in- trathymic ...proliferative response to chromatin in short term organ cul- ture of neonatal ...
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Thesis
... Based on the above studies, we propose that endogenous IFNβ plays an active role in the suppression of the inflammatory responses that give rise to RRMS. Its decreased secretion in RRMS patients may contribute to ...
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Evolving liver inflammation in biochemically normal individuals with anti-mitochondria antibodies
... Liver histology has not been thoroughly studied in bio- chemically normal AMA-positive (BN/AMA-positive) individuals. This is due in part to ethical constraints in obtaining biopsy liver fragments from BN/AMA-posi- tive ...
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A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin 1)
... immune response against cartilage collagen II can be ...an autoimmune response to cartilage proteins is involved in RA and RP, the different patterns of affect- ed tissues can best be explained if ...
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Vol 28, No 1 (2018)
... Abstract Autoimmune progesterone dermatitis (AIPD) is a rare autoimmune response to endogenous progesterone, characterized by cyclic cutaneous and mucosal lesions at the end of the luteal phase with ...
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Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis
... and were resistant to EAMG [25]. A recent study on rat myocytes suggests that the IL-4 receptor provides a link between the immune system and muscle in EAMG [26]. Overproduction of IL-6 also plays an important role in ...
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The CII specific autoimmune T cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis
... an autoimmune T-cell response is fingolimod ...experimental autoimmune encephalomyelitis (EAE) [18], diabetes [19], and inflammatory bowel disease ...other autoimmune disease models, such as ...
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Chitin Micro Particles Regulate Splenocytes Immune Response in Experimental Autoimmune Encephalomyelitis
... To verify whether CMPs could indeed up-regulate IL-10/IFN-γ axis, isolated spleen cells from the myelin oligodendrocyte glycoprotein (MOG) induced experimental autoimmune encephalomyelitis (EAE) mice were cultured ...
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Immunosuppressive therapy with rituximab in common variable immunodeficiency
... of autoimmune and lymphoproliferative manifestations associated with primary immunodeficien- cies, and in particular with common variable immuno- deficiency (CVID) ...in response to pathogens and vaccines ...
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Cutaneous vasculitis in patients with autoimmune polyendocrine syndrome type 1: report of a case and brief review of the literature
... dysfunction, autoimmune hepatitis, asplenia and various ectodermal abnormalities (interstitial keratitis, alo- pecia, vitiligo, nail dystrophy and dental enamel hypoplasia), may occur with a different prevalence ...
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KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis
... which generally cause adverse side effects [24]. To avoid these negative effects and to increase therapeutic effect- iveness, development of therapies that target the mo- lecular pathways responsible for induction of ...
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Intravenous immunoglobulin therapy in vasculitic ulcers: a case of polyarteritis nodosa
... In January 2005, she presented with livedo reticularis, cutaneous nodules, lower limb edema, fever and arthral- gias. Erythrocyte sedimentation rate (ESR) was elevated (100 mm/h) (Fig. 1). Autoantibodies, including ...
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Original Article Circulating L-selectin expressing-T cell subsets correlate with the severity of Foxp3 deficiency autoimmune disease
... Treg-deficient autoimmune disease. Currently, autoimmune disease activi- ty is monitored by clinical symptoms and by using nonspecific blood markers such as eryth- rocyte sedimentation rate (ESR) and ...
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Recalcitrant Hypocalcaemia in Autoimmune Enteropathy
... of autoimmune diseases includ- ing systemic lupus erythematosus, Sjogren syndrome, ulcerative colitis, and thyroid disease was present in fi rst- and second-degree ...
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