autophagic cell death (ACD)
Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells
... induce autophagic cell death ...inhibited cell proliferation, and ultimately induced cell death in the human cancer cell lines DLD-1, HepG2, and Caco-2, but not in A549, ...
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Autophagic cell death: A new frontier in cancer research
... ing cell growth and the homeostasis of ...in cell physiology, auto- phagy is closely linked to both tumorigenesis and cancer cell response to ...cancer cell death or protects cancer ...
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Suppression of PC-1/PrLZ sensitizes prostate cancer cells to ionizing radiation by attenuating DNA damage repair and inducing autophagic cell death
... acridine orange-positive cells increased from 18.17% to 58.58% for C4-2 NC cells and 47.91% to 80.96% for C4-2 sh cells. In addition, increased expression of LC3B was observed, which is a hallmark of autophagy, and p62 ...
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Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia
... leukemia cell lines, lapatinib induced apoptosis in HL-60, NB4, and Jurkat cells, but induced nonapoptotic cell death in U937, K562, and MEG-01 ...caused autophagic cell death as ...
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<p>Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation</p>
... cause autophagic cell death in cancer ...exact autophagic mechanism of MO, an autop- hagy fl ux assay and an autophagy inhibitor study were carried out in the current ...by autophagic ...
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Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia
... infected cell significantly augments the therapeutic ...the autophagic vesicles detected by four independent approaches: TEM, AVO staining, LC3-I to LC3-II conversion by Western blotting and LC3 ...
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Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal
... of cell death by Atg7 knockdown in HCN cells, these data revealed that ACD was the primary cell death mechan- ism in insulin-deprived HCN cells, which manifested in- creased levels of ...
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Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death
... As is known to all, Akt/mTOR signaling pathway par- ticipates in multiple cellular functions, including cell sur- vival, differentiation, and autophagy [20].The Akt/mTOR signaling pathway could negatively regulate ...
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<p>Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling</p>
... NOD-SCID mice (6 – 8 weeks) were housed in the ventilated cage with a temperature of 22± 2°C and a 12:12 h light/dark cycle. All mice were irradiated with a sublethal dose of 250 cGy γ -radiation using a radiation source ...
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Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth
... and p62-depleted cells, we treated C13 NTC and p62 shRNA clones with 0, 5.0, 10.0 μM of QC for 24 hours. Evaluation of apoptotic marker proteins by western blot analysis revealed that p62 knockdown cells exhibited higher ...
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Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma
... cells, cell cycle analysis revealed significantly higher percentage of G0/G1-phase cells in the combination group than in the single-agent and the con- trol group, indicating that co-treatment of VPA ...BL ...
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PKM2 Knockdown Induces Autophagic Cell Death via the AKT/mTOR Pathway in Human Prostate Cancer Cells
... cell lines by performing western blotting analysis and found that PKM2 protein levels were high in 251.. prostate cancer DU145 cells as well as in other cancer cell lines (Fig..[r] ...
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Autophagic cell death participates in POMC induced melanoma suppression
... POMC gene therapy elicits autophagy in melanoma in vivo Because it is known that POMC gene therapy induces apoptosis in melanoma via α -MSH during hypoxic challenge 29 , we would like to elucidate whether autop- hagy ...
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Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment
... apoptotic cell death in the tumor ...programmed cell death, while uncontrolled autophagy itself often induces autophagic cell death in tumor ...cells. Autophagic ...
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Targeting AMPK for cancer prevention and treatment
... More recently, pre-clinical studies have shown AMPK having some involvement in others cancers, including melanoma [11, 48-52], breast cancer [53-56], prostate cancer [57, 58], ovarian cancer [59, 60] and leukemia’s [61]. ...
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Pathology of Cell Death
... 15. Gamonal J, Bascones A, Acevedo A, Blanco E, Silva A. Apoptosis in chronic adult periodontism analyzed by In Situ DNA breaks, electron microscopy and immunohistochemistry. J Periodontol 2001;72(4):517-525. 16. ...
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Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
... on cell growth, autophagy, and epithelial-to-mesenchymal transition (EMT) and to delineate the possible molecular mechanisms in human pancreatic cancer PANC-1 and BxPC-3 ...potent cell growth inhibitory, ...
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Autophagy induced tumor dormancy in ovarian cancer
... cancer cell death and ...in autophagic cell death of human ovarian cancer cells in vitro (see the related article, ...tumor cell survival, leading to tumor ...
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Lectin of Concanavalin A as an anti-hepatoma therapeutic agent
... and cell death in a dose- and time-dependent manner. For tumor cell lines, a high dose is cytotoxic whereas a low dose is ...different cell lines: the IC 50 of Con A for HepG2, CT-26, ML-1, ...
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Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation
... cancer cell survival, whereas a high level of au- tophagy results in autophagic cell death ...cancer cell type/phase, stress context and the ...or death of the cell is ...
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