Autoreactive CD4 T cells
Characterization and modulation of autoreactive CD4+ T cells in type 1 diabetes
... of autoreactive T cells that are found at late preclinical T1D or once diabetes has been ...both autoreactive and nonautoreactive T cells are affected, therefore raising the ...
173
Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα
... myelin-specific CD4 T cells, splenocytes from naïve TCR ...myelin-specific T cells and allow for evaluation of a myelin-specific response in a diverse T cell population, were ...
12
Thymus specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice
... nonhematopoietic cells could lead to disease ...diabetogenic T cell specificities by TECs lacking Tssp, although one cannot exclude that, under such conditions, negative selection, driven either directly by ...
13
Direct modulation of myelin-autoreactive CD4<sup>+</sup> and CD8<sup>+</sup> T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules
... the autoreactive T cells in vivo mainly in a direct contact way, but an indirect pathway mediated by Tregs and tolerogenic APCs may also be involved in this ...More T cell epitopes derived ...
20
Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation
... IC-specific T cells to induce GC differentiation of AM14 B cells may be reflective of events in later stages of ...cognate T cells was needed to elicit GC for- mation in response to ...
18
Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa 1 peptide complexes
... of autoreactive T cells to provoke autoimmune disease is well ...attenuated autoreactive T cells (T cell vaccination, or TCV) can induce T cell–dependent inhibi- ...
8
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
... nonself. T cell tolerance is achieved primarily through the elimi- nation of potentially autoreactive clones in the thymus through a mechanism known as negative selection (1, ...tolerance, ...
8
CD1b autoreactive T cells contribute to hyperlipidemia induced skin inflammation in mice
... staining, cells were preincubated with purified ...staining, cells were stim- ulated with PMA and ionomycin for 4 hours, followed by addition of brefeldin A for 2 ...hours. Cells were surface stained ...
15
Quantitative and functional analysis of PDC E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
... by autoreactive T cells infiltrating the intrahepatic bile ...of CD4 + autoreactive T cells in the liver that are specific for peptides encoded by the E2 components of the ...
11
The Influence of Cd4+ T Cell Affinity for Self-Antigen on the Development of Inflammatory Arthritis
... CD4+ T cells make a crucial contribution to the development of inflammatory arthritis both in humans and in mouse ...which T cells recognize target antigens might shape disease ...
178
Characterization of an epigenetically altered CD4+ CD28+ Kir+ T Cell subset in autoimmune rheumatic diseases by multiparameter flow cytometry
... altered CD4 + CD28 + T cell subset is also found in patients with related autoimmune rheumatic diseases including RA, SSc and possibly Sjögren ’ s syndrome, and the size of the subset is similarly related ...
9
Lentiviral mediated gene therapy restores B cell tolerance in Wiskott Aldrich syndrome patients
... B cells of GT-treated WAS ...B cells, all treated patients displayed a significantly decreased frequency ...B cells after GT compared with ...other T cells from WAS patients after GT, ...
12
HIV restriction in quiescent CD4+T cells
... quiescent T cells raised the possibility that quiescent T cells can be a reservoir that could support a spreading ...resting cells of HIV infected patients but this was attributed to ...
9
Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response
... Moreover, IL-6 seems to affect the proliferation and acti- vation of monocytes that express IL-6R [13,14]. How- ever, because in previous studies the number of patients, the period of study and the examined cell ...
10
CD4+ T Cells Develop Antiretroviral Cytotoxic Activity in the Absence of Regulatory T Cells and CD8+ T Cells
... whether CD4 ⫹ T cells might be able to compensate for the lack of cytotoxic T cells in CD8-depleted mice, especially when no Tregs were present to modulate their ...⫹ T ...
8
Heterogeneity of human effector CD4+T cells
... dendritic cells, acted as powerful inducers of human Th1 polarization [10-12], I hypo- thesized that the type of innate immunity response was the main conditioning mechanism for the type of subsequent adaptive ...
8
Hypomethylation and overexpression of ITGAL (CD11a) in CD4+ T cells in systemic sclerosis
... between T cells and different cell types; this is important in inflammatory and immune re- sponses ...activated CD4 + T cell has been observed in peripheral blood, skin lesions, and gastric ...
12
Clonal analysis of CD4+ T cells
... f T cells occurs in lymphoid organs including the lymph nodes, spleen and mucosal associated lymphoid tissue, where antigen presenting cells come into contact with naïve T cells in ...
243
Original Article High CD4 T cell density is associated with poor prognosis in patients with non-muscle-invasive bladder cancer
... High-risk Non-muscle-invasive bladder cancer (NMIBC) is clinically characterized by high recur- rence rates and represents one of the most costly cancers [1]. Bacillus Calmette-Guerin immune therapy has been used to ...
7
Protective efficacy of recombinant canine adenovirus type 2 expressing TgROP18 (CAV 2 ROP18) against acute and chronic Toxoplasma gondii infection in mice
... Regarding the vaccine vectors used for ROP18 expression of T. gondii, we started our work with the replication- competent CAV. Besides being highly efficient for trans- gene expression “in vivo” and being safe for ...
10