Aβ(1–42) peptide
EVALUATION OF NOVEL LIGAND FOR THE MAINTENANCE OF NATIVE Aβ(1 42) PEPTIDE CONFORMATION: RELEVANCE TO ALZHEIMER’S DISEASE
... human Aβ, we concentrated on 2 partial surfaces of this Aβ ...in Aβ helix adjacent to Glu-22 and Asp-23 is a surface containing Phe-20, which connects these residues with Lys-16 and ...of Aβ ...
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ApoE mimetic peptide decreases Aβ production in vitro and in vivo
... derived peptide analogs could affect Aβ production, we treated a human PS1-overexpressing cell line (PS70) with the apoE mimetic peptides at various concentrations (30 nM to 3 μM) for 24 h and measured ...
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Retro inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer’s Aβ peptide
... future. 1 Current drug treatments only temporarily alleviate the symptoms of ...Amyloid-β peptide (Aβ) fibrils, and neurofibrillary tangles consisting of hyperphosphorylated Tau ...However, Aβ ...
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Aβ Like Peptide Displayed on Bacteriophage T7 Catalyzes Chromate and Uranyl Reduction
... β-amyloid peptide (Aβ) known to promote aggregation and formation of high-affinity metal binding ...the 42 amino-acid Aβ-peptides that have been found to catalyze the NADH-dependent reduction ...
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Stereochemistry and amyloid inhibition : asymmetric triplex metallohelices enantioselectively bind to Aβ peptide
... Ab40/Ab42 aggregation involves formation of b sheet–rich frame- works, which can be determined by circular dichroism (CD; a wide band near 217 nm). We calculated the proportional contribution of the b sheet structure in ...
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Evaluating the olfactory dysfunction and cognitive deficits induced by intracerebroventricular injection of Amyloid beta (1–42) in female C57BL/6 mice
... of Aβ oligomers is reported to compromise acetylcholine neurotransmission and thereby cause neurotransmitter ...imbalances. Aβ has been found to complex with AChE and potentiate the neurodegenerative ...
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Matriptase cleaves the amyloid beta peptide 1–42 at Arg 5, Lys 16, and Lys 28
... an Aβ peptide-cleav- ing protease, other proteases of different classes have been reported to do so, as ...enzyme 1, an aspartic protease), BACE2 cleaves at F19 and F20 ...the Aβ peptides, at ...
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The Evolution of Aβ Peptide Burden in the APP23 Transgenic Mice: Implications for Aβ Deposition in Alzheimer Disease
... sequence 1–17, and R163 and R165 against the C-terminal portions of the A peptide ending at amino acids 40 and 42 (20), respectively (all three were used at a dilution of ...of 1:100, and for ...
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Differential effects of amyloid-beta peptide aggregation status on <em>in vivo</em> retinal neurotoxicity
... soluble Aβ 1–42 or Aβ 1–42 preaggregated for different periods, retinal pathology was evaluated at 24 hours, 48 hours, and 1-month postin- ...soluble Aβ (sAβ) or ...
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Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes
... and Aβ as the source of AD-associated inflammation ...than Aβ acting as a sole independent initiator of neuro- inflammation, increased Aβ may trigger dysregulation of the innate immune system through ...
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Seeser, Franziska Katharina (2018): Die Bedeutung der NMDA-Rezeptoruntereinheit NR2B in der Vermittlung synaptotoxischer Effekte verschiedener Amyloid β-Arten. Dissertation, LMU München: Tierärztliche Fakultät
... oder 42 Aminosäuren, und sie vermuteten, dass es aus einem größeren Vorläuferprotein abgespalten ...der Aβ-Plaques, welche ein charakteristisches pathologisches Merkmal der Alzheimer Krankheit ...zwischen ...
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Amyloid at the cutting edge: activation of α secretase prevents amyloidogenesis in an Alzheimer disease mouse model
... the Aβ peptide domain, its activa- tion may even have the double advantage of not only precluding the neurotoxic Aβ peptide formation but also generating the putatively neuroprotective sAPPα ...
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Mitochondrial β amyloid in Alzheimer's disease
... fusion peptide to allow the peptide to cross the cell membrane, found that application of the peptide was protecting neurons (from wild type, Tg-ABAD and Tg-ABAD/mAPP mice) against Aβ-induced ...
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Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells
... of Aβ is a key therapeutic target that can be investigated in cells transfected with the human APP gene; which metabolise APP to toxic forms of Aβ ...produce Aβ that are of similar size and potency ...
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Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics
... example, peptide properties including retention time and m/z were different in each ...the peptide used for the MS assay is present in all 5 NrCAM isoforms, which would account for the higher value observed ...
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Glial activation and inflammation along the Alzheimer’s disease continuum
... For the purposes of the present study, we selected 121 participants from two Norwegian cohorts. Healthy con- trols with normal CSF (n = 36), participants with SCD (n = 18), and MCI (n = 20) patients, both with CSF Aβ42 ...
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Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications
... for Aβ, another specifi c for neurodegeneration to establish AD as the probable pathophysiology) has face validity ...CSF Aβ 1–42 levels across the AD continuum [91], how CSF AD biomarkers and ...
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Asparagus cochinchinensis stimulates release of nerve growth factor and abrogates oxidative stress in the Tg2576 model for Alzheimer’s disease
... Various attempts have reported several pathological mechanisms as the main cellular targets to prevent or retard the progression of AD to disease states [2]. Most approaches are designed to block or mitigate several ...
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Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease
... of Aβ oligomers in the plasma and other AD ...the Aβ oligo- mers by MDS was also comparable with that of other conventional AD ...of Aβ oligomers, which is considered a core patho- logical feature of ...
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Ferrous iron formation following the co aggregation of ferric iron and the Alzheimer's disease peptide β amyloid (1 42)
... during peptide storage, thereby reverting amyloid aggregation (as recommended by the peptide manufac- ...complete peptide dissolution before being immedia- tely added to modified Krebs –Henseleit ...
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