Axonal Degeneration
Diffusion Tensor Imaging of Normal Appearing White Matter in Mild Cognitive Impairment and Early Alzheimer Disease: Preliminary Evidence of Axonal Degeneration in the Temporal Lobe
... In this study, we found evidence for functionally relevant mi- crostructural changes in the NAWM of patients with AD and MCI. These changes were present in brain regions serving higher cortical functions (frontal, ...
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Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?
... Axonal degeneration is a major determinant of permanent neurological impairment during multiple sclerosis ...governing axonal degeneration may differ between disease ...identifying ...
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Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury
... axon degeneration in human pathological ...acute axonal degeneration in neonatal, infant, and adult hypoxic-ischemic injury as well as in a sample of an active multiple sclerosis ...of axonal ...
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Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice
... There are widespread central and peripheral nervous system manifestations of Fabry disease. Peripheral ner- vous system involvement includes small fiber neuropathy that is associated with neuropathic pain and autonomic ...
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Restoring mitofusin balance prevents axonal degeneration in a Charcot Marie Tooth type 2A model
... Mitofusin-2 (MFN2) is a mitochondrial outer-membrane protein that plays a pivotal role in mitochondrial dynamics in most tissues, yet mutations in MFN2, which cause Charcot-Marie-Tooth disease type 2A (CMT2A), primarily ...
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Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice
... neuritic degeneration in human neurons, as shown previously with Z-VEID-fmk and Casp6 dominant negative inhibi- tors ...in axonal degeneration of NGF-dependent neurons, recent evidence suggests that ...
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Axonal degeneration in paraplegin deficient mice is associated with abnormal mitochondria and impairment of axonal transport
... diseases, axonal degeneration occurs before neuronal death and contributes significantly to patients’ ...selective degeneration of axons of the corticospinal tracts and fasciculus ...by axonal ...
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Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
... peripheral axonal degeneration or demyelination (see ...and axonal dystrophy (data not shown) within the fasciculus gracilis, an axonal tract that regulates hind limb proprioception and ...
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Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
... Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two related neurodegenerative disor- ders with overlapping molecular disease pathways. In FTD, neuronal loss in the frontal and anterior temporal ...
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... in newborns shows signifi cant morphologic changes in population of neuronal cells in dorsal vagal motoric nu- cleus (MNDV) as well as in sensor dorsal nucleus (NTS) in shape of central chromatolysis “axonal ...
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Nerve pathologic features differentiate POEMS syndrome from CIDP
... more axonal loss as evidenced by reduced amplitudes of motor and sensory potentials and greater degrees of fibrillation potentials than does CIDP [7, 19, ...of axonal degeneration in POEMS syndrome ...
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Correlates of degree of nerve involvement in early Bell's palsy
... rian degeneration starts in 3–5 days and maximal injury usually occurs within 1–2 weeks ...of axonal damage to the facial nerves ...with axonal degeneration in early Bell's palsy) was ...
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Role of Calpains in Axonal Injury and Degeneration
... of axonal transport with subsequent accumulation of transported proteins and organelles, commonly visualized using antibodies targeting beta-amyloid precursor protein (ß-APP) or nonphosphorylated neurofilament, ...
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NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo
... the axonal NAD-synthesizing enzyme NMNAT2 to ...triggers axonal degeneration or defective axon ...that axonal NMNAT2 primarily promotes axon survival by maintaining low levels of its sub- ...
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Anti ganglioside Antibody profile in GBS - Clinical, Immunological and Neurophysiological significance.
... direct axonal attack or through the activation of the complement system which ultimately result in resulting in predominant axonal damage with minimal ...This axonal damage is histologically ...
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Neuroprotective therapies for multiple sclerosis and other demyelinating diseases
... and axonal loss both in the grey and white matter [58, ...process, axonal degeneration takes place in CNS areas already damaged long time ago because of the lack of myelin support, presence of an ...
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Targeting microtubules in the distal neuromuscular circuitry to improve outcomes in amyotrophic lateral sclerosis
... during axonal growth (Munnamalai and Suter, 2009; Wilson and Gonzalez-Billault, 2015), aberrant ROS and increases oxidative environment can lead to deleterious impacts on microtubules, particularly oxidation of ...
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Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis
... amend axonal degeneration ...Wallerian degeneration of the dis- tal stump is a Ca 2+ -mediated process [53, ...in axonal degeneration observed in Wld S axons is only ...inflammatory ...
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Novel pathomechanisms in inflammatory neuropathies
... These data are supported by another study from Brazil during the recent major ZIKV outbreak. Between December 2015 and May 2016, evidence of recent ZIKV infection was found in serum and/or CSF of 77% of all GBS patients. ...
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Lamin B1 mediates cell autonomous neuropathology in a leukodystrophy mouse model
... brane (3). Mutations of the X-linked PLP1 gene encoding PLP, the most abundant protein of the CNS myelin sheath, cause Pelizaeus- Merzbacher disease (PMD), another rare leukodystrophy (4). Muta- tions in PLP1 ultimately ...
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