B cell maturation
Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice
... T cell compartment did not reveal ...intestine, B cell cellularity and the number and size of Peyer’s patches were drastically reduced, and serum IgM levels were significantly ...pre–B ...
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CTLA4Ig inhibits T cell–dependent B cell maturation in murine systemic lupus erythematosus
... This study was designed to add to our understanding of how CTLA4Ig affects an ongoing autoimmune response. We have engineered an adenovirus that expresses murine CTLA4Ig (Ad-CTLA4Ig). Administra- tion of a single high ...
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Differential Roles of Estrogen Receptors α and β in Control of B-Cell Maturation and Selection
... on B-cell maturation and ...on B-cell de- velopment and selection without the confounding factors present in an auto- immune ...decrease B-cell lymphopoiesis in the bone ...
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B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma
... needed. B cell maturation antigen (BCMA) is a cell surface receptor expressed primarily by plasma ...plasma cell homeostasis (1). BCMA is expressed consistently on MM cell lines ...
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Increased Expression of B Lymphocyte Induced Maturation Protein 1 (BLIMP1) in Patients with Common Variable Immunodeficiency (CVID)
... in B cell differentiation, impaired immunoglobulin production, and defect in response to ...defective B cell maturation and differentiation in CVID, the affected patients commonly ...
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B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8⁻ dendritic cells require the intramembrane endopeptidase SPPL2A
... mature B cells normally (Benlagha et ...in B cell maturation remains ...T cell matura- tion and leukemia (Selkoe and Kopan, ...on B cells, revealing a critical role for regulated ...
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Tumor necrosis factor superfamily member APRIL contributes to fibrotic scar formation after spinal cord injury
... and B cell survival and proliferation ...9], B cells, and activated T cells [10] ex- press APRIL, and APRIL can interact with transmem- brane activator and CAML interactor (TACI), B ...
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Antibody Avidity in Humoral Immune Responses in Bangladeshi Children and Adults following Administration of an Oral Killed Cholera Vaccine
... memory B cell responses waned by 42 days following ...T cell-depen- dent antigens following vaccination may provide evidence of lon- ger-term immune maturation than measured by the current ...
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CAR-T “the living drugs”, immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy
... T cell engagers, and antibody- drug conjugates make the antibody-directed agents more powerful with less ...T cell products. Several CAR-T cell platforms targeting B cell ...
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Cancer biomarkers for targeted therapy
... T cell engagers, and antibody-drug ...CLL-1, B cell maturation antigen, and CD138 are targets for cancer immunotherapeutic agents, including the chimeric antigen receptor - engineered T ...
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<p>Coexistence Of A Huge Venous Thromboembolism And Bleeding Tendency In Cytokine Release Syndrome During CAR-T Therapy</p>
... The 62-year-old male patient was diagnosed with MM (Isotype IgG- λ ; DS stage IIIB; R-ISS III) in April 2016. After the patient received a regimen of bortezomib, doxorubi- cin, and dexamethasone (PAD) for four cycles, CR ...
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Plasma cells within granulomatous inflammation display signs pointing to autoreactivity and destruction in granulomatosis with polyangiitis
... plasma cell development and survival in nasal tissue in ...whether B-cell superantigens (for example, staphylococcal protein A, staphylococcal enterotoxin D) [24] might play a role in GPA, which, for ...
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T cell senescence and CAR-T cell exhaustion in hematological malignancies
... Treg cell mechanism of forcing T cells into senescence ...Treg cell accumulations in hematological malignancies such as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic ...
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Design Principles Of Mammalian Transcriptional Regulation
... per cell was measured by counting mean transcription sites, transcription site intensity was calculated as the mean fluorescence intensity of those sites calculated by 2D Gaussian fitting, and Pol II traveling ...
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Investigation into the structure of flavocytochrome b558
... Glycosylation can be manipulated for experimental study. Approaches include the enzymatic or chemical removal of completed chains, prevention of initial glycosylation, alteration of processing, elimination of specific ...
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Chimeric antigen receptor T cell therapies for multiple myeloma
... Antibody-dependent cell-mediated cytotoxicity; AE: Adverse event; ALL: Acute lymphocytic leukemia; APRIL: A proliferation-inducing ligand; ASCO: American Society Clinical Oncology; ASCT: Autologous stem ...
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Maturation of the Human Papillomavirus 16 Capsid
... Pseudovirion and virion purification. Capsids were purified from clarified cell lysate using agarose gel filtration columns. Non-cross-linked agarose beads (2%; Agarose Bead Technologies) were poured into 2-ml ...
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MerTK mediates immune homeostasis: effects upon dendritic cell function and Type 1 diabetes
... molecules such as CD40, CD80 and CD86 (Mahnke et al., 2002). The many phagocytic receptors of DC allow ingestion of a wide variety of antigens including microbial pathogens or necrotic tissue laden with microbial ...
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Six3 is required for ependymal cell maturation
... To identify possible functional roles of Six3 during later stages of brain development, we compared its expression pattern in P4 and P15 brains with that of the astrocyte marker Gfap, the progenitor marker Ascl1, the ...
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Maturation-Associated Destabilization of Hepatitis B Virus Nucleocapsid
... NC maturation is associated with a gain of PK sensitivity and decreased ...pAD38 cell lysate or sucrose gradient fractions prepared from the lysate with- out MNase ...
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