BA, Baicalin
In-silico study of herbal compounds (baicalin, curcumin and dronabinol) as novel mao inhibitors for parkinson's disease treatment
... Free energy of binding with Baicalin was -8.51 kcal/mol with 40% frequency and Est. Inhibition Constant, Ki was found to be 575.20 nM. VdW + Hbond + desolv Energy and Electrostatic Energy was -9.76 kcal/mol, -0.12 ...
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Baicalin regulates the dopamine system to control the core symptoms of ADHD
... of baicalin on attention deficit hyperactivity disorder (ADHD) in an animal model and to explain the potential ...of baicalin in a spontaneously hypertensive rat (SHR) model of ADHD depending on the ...
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Lung-targeting drug delivery system of baicalin-loaded nanoliposomes: development, biodistribution in rabbits, and pharmacodynamics in nude mice bearing orthotopic human lung cancer
... of baicalin solution was observed in a time-dependent ...of baicalin-loaded nanoliposomes, the biodistribution in plasma, heart, and lung was found to be in a time-dependent manner, whereas the ...
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Investigation of the interaction between baicalin and human serum albumin by a spectroscopic method and molecular modeling
... between baicalin and human serum albumin(HSA), had been investigated by fluorescence spectroscopic, ultraviolet spectrum(UV), Fourier transform infrared(FT-IR), circular dichroism(CD) and molecular ...that ...
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Process optimization and evaluation of novel baicalin solid nanocrystals
... Therefore, morphology evaluation of the redispersed BCN- NS is needed. In this study, the morphology of the freshly prepared BCN-NS and redispersed BCN-NS after lyophiliza- tion was evaluated by TEM (Figure 4). TEM ...
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Electrochemical Determination of Baicalein, Baicalin and Quercetin in Scutellaria barbata
... The sensitivity of the proposed CE-ED technique for the determination of baicalein, baicalin and quercetin was greatly influenced by the applied potential for working electrode. As demonstrated in Fig. 2A, the ...
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The protective effect of baicalin against renal ischemia reperfusion injury through inhibition of inflammation and apoptosis
... affected. Baicalin treatment inhibited the increased expression of the proinflammatory cytokines TLR2/4, MyD88, p-NF-κB, and p- IκB, as well as increase the expression of IκB protein, an NF-κB inhibitor, with the ...
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Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca<sup>2+</sup>-dependent pathway
... of baicalin on glio- blastoma growth in vivo, the immune-deficient nude mice bearing U87 tumor xenografts were ...or baicalin (50, 100 ...that baicalin lowered the expression of Ki-67, which serves ...
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Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin
... Although baicalin has been found to induce apoptosis in several malignant hematologic cell types, the mechan- ism responsible for the induction has not been examined in ...detail. Baicalin treatment has ...
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Production of Baicalin, Baicalein and Wogonin in Hairy Root Culture of American Skullcap (Scutellaria lateriflora) by Auxin Treatment
... glycosides baicalin, dihydrobaicalin, ikonnikoside I, and scutellarin, and the aglycones baicalein, oroxylin A, and wogonin; amino acids; and chalcones are contained in American ...Moreover, baicalin, ...
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Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes
... for BA-CMC, drug concentration was relatively high in the kidney and lung but low in the heart and the brain; for BA-LP, drug concentration was signifi- cantly increased in the liver, spleen, and lung, to ...
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Baicalin reverses radioresistance in nasopharyngeal carcinoma by downregulating autophagy
... out 10 μg/ml baicalin and 4 Gy X-ray dose. Protein lysates were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis and transferred to nitrocellulose mem- branes (Millipore, Billerica, MA). The ...
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Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
... that Baicalin treatment remarkably reduced MDA content and increased GPx and SOD activities accompanied with elevated expressions of GPx1 and SOD1 in injury brain tissues compared with the V group at 24 hours ...
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Original Article Up-regulation of miR-200b by baicalin to inhibit migration of MCF-7 breast cancer cells
... migration. Baicalin is one flavonoids compound extracted from scutellaria of family ...found Baicalin could inhibit tumor cell migration but did not know its correlation with ...of Baicalin on cell ...
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Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation
... of baicalin from nanoemulsions com- pared with drug suspensions was studied using a dialysis bag method (molecular weight cut-off [MWCO] 8,000–14,000) in 400 mL of artificial gastric juice ...free baicalin ...
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Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway
... of baicalin on CUMS-induced depressive-like behaviors of mice, we performed behavioral tests including SPT, OFT, TST, and FST as successively shown in ...with baicalin (60 mg/kg, p < ...with ...
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<p>Neuroprotective effect and mechanism of baicalin on Parkinson’s disease model induced by 6-OHDA</p>
... Results: Baicalin treatment improved the rod time and voluntary movement in rat model of PD ...addition, baicalin also protected from oxidative stress injury ...of baicalin. Conclusion: ...
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Original Article MicroRNA-122 mediates the protective effect of baicalin on liver fibrosis
... dose baicalin + CCl 4 group, medium dose baicalin + CCl 4 group, and high dose baicalin + CCl 4 ...For baicalin treatment, mice were gavaged with indicated doses of baicalin in 1% ...
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Baicalin, a natural compound, promotes regulatory T cell differentiation
... Baicalin up-regulates Foxp3 expression in HEK 293 T cells After transfection with pZIGF, HEK 293 T cells were treated with Baicalin, which resulted in both dose- and time- dependent increases in the ...
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<p>Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury</p>
... Through various aspects of the preparation process of BO-BA-LP, we can see that there are many factors that affect the liposome encapsulation rate and drug loading. After a single-factor investigation, we found ...
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