Bacterial type IV secretion system
Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens
... While we identified these small molecules as chemical probes to interrogate H. pylori cag T4SS biogenesis, our findings provide a foundation for the potential development of H. pylori-specific anti-virulence strategies ...
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Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress Mediated Cell Death and Fetal Loss via Type IV Secretion System Dependent Activation of CHOP
... conditions. Bacterial strains used in this study were the virulent strain ...rpm). Bacterial inocula for mouse infection were cultured on tryptic soy agar plus 5% blood for 3 ...
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Structure of a bacterial type IV secretion core complex at subnanometre resolution
... VirB/D system from ...VirB/D system consists of 12 proteins named VirB1–VirB11 and VirD4 that form a multi- protein envelope-spanning transport ...the secretion system (Gomis-Ruth et al, 2001; ...
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Sensing of Bacterial Type IV Secretion via the Unfolded Protein Response
... immune system by the Brucella T4SS is triggered directly, through the recognition of one or more of its effectors by host ...the secretion of proinflamma- tory cytokines interleukin-6 (IL-6) and tumor ...
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Higher glucose level can enhance the H. pylori adhesion and virulence related with type IV secretion system in AGS cells
... that bacterial adhesion to gastric epithelial cells can be enhanced by a higher glucose ...that bacterial factors may play a more important role in increasing ...
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Membrane and Core Periplasmic Agrobacterium tumefaciens Virulence Type IV Secretion System Components Localize to Multiple Sites around the Bacterial Perimeter during Lateral Attachment to Plant Cells
... plasmid (pTi). The vir-T4SS transports pTi-encoded single-stranded DNA (T strand) and at least four Vir proteins, VirD2, VirE2, VirE3, and VirF, into host cells. Insertion of the T strand into plant genomic DNA and its ...
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In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System
... ype IV secretion systems (T4SSs) are deployed by most species of bacteria for the conjugative transfer of mobile genetic elements (MGEs) to other bacteria and by many pathogenic species of bacteria for the ...
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Structural organisation of the type IV secretion systems
... which type IV secretion (T4S) systems form the most functionally ver- satile class ...of secretion systems from the ...one bacterial cell to another in a process called conjugation that ...
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Identification of a Novel Conjugative Plasmid in Mycobacteria That Requires Both Type IV and Type VII Secretion
... myco- bacterial cell envelope contains an outer membrane that is com- posed mainly of long-chain fatty acids, known as mycolic acids, which are partially linked to the arabinogalactan-peptidoglycan complex and ...
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Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways
... lates. Bacterial virulence factors exert an important influence in determining the clinical outcomes, and clinically isolated ...to bacterial virulence ...a type IV secretion ...
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Zhao, Qing (2017): Integrin-independent Helicobacter pylori CagA translocation via type IV secretion. Dissertation, LMU München: Medizinische Fakultät
... cag type IV secretion system ( cag -T4SS), a needle-like apparatus protruding from the bacterial surface, which is able to inject the effector protein CagA (cytotoxin- associated gene ...
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Type IV secretion systems: versatility and diversity in function
... Legionella pneumophila is a Gram-negative facultative intracellular parasite, which is the causative agent of a type of pneumonia called Legionnaire’s disease. It has a history of contaminating water distribution ...
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A Novel Mechanism for Protein Delivery by the Type 3 Secretion System for Extracellularly Secreted Proteins
... The type 3 secretion system (T3SS) is essential for bacterial virulence through delivering effector proteins directly into the host ...
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Translocation through the Conjugative Type IV Secretion System requires unfolding of its protein substrate
... ABSTRACT Bacterial conjugation, a mechanism of horizontal gene transfer, is the major means by which antibiotic resistance spreads among bacteria (1, ...a type IV se- cretion system (T4SS) in ...
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Type IV Pili Can Mediate Bacterial Motility within Epithelial Cells
... the type III secretion system (T3SS) of invasive ...either type IV pili (T4P) or T4P- dependent twitching motility (i) were defective in traversing cell multilayers, (ii) caused less ...
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Postreplication Roles of the Brucella VirB Type IV Secretion System Uncovered via Conditional Expression of the VirB11 ATPase
... the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host phagocytes, where it undergoes an intracellular cycle within a dedicated membrane-bound vacuole, the Brucella-containing vacuole ...
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Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex
... multiple bacterial species are likely to be required for core com- plex formation, whereas proteins unique to ...IL-8 secretion in AGS cells (indicating the absence of a functional cag T4SS) ...
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Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori
... HtrA secretion, cleavage of E-cadherin, bacterial transmigration and delivery of the type IV secretion system (T4SS) effector protein CagA into polarized epithelial cells, but ...
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Type IV secretion in Gram negative and Gram positive bacteria
... a truncated pKM101 core structure, lacking the N-terminus of VirB10 (Fig. 1G, bottom), was determined at 8.5 Å resolution and provided further details on the structure of the I-layer (Rivera-Calzada et al., 2013). The ...
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Self Labeling Enzyme Tags for Analyses of Translocation of Type III Secretion System Effector Proteins
... The single-molecule tracking of SPI2-T3SS effector SseF showed a rapid movement comparable to the mobility of host transmembrane protein LAMP1 along the SIF tubule. The movement has a bidirectional pattern. Lateral ...
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