BARBITURIC ACID DERIVATIVES
Tandem Aldol-Michael reactions in aqueous diethylamine medium: a greener and efficient approach to dimedone-barbituric acid derivatives
... Zwitterion derivatives 4a-p via a three-component condensation reaction of barbituric acid derivatives 1a,b, dimedone 2, and various aldehydes 3 in the presence of aqueous diethylamine media ...
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Tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives using isonicotinic acid as an efficient catalyst
... dione derivatives by the tandem Knoevenagel-Michael- cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives at the presence of isonicotinic acid ...
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Solvent free green Synthesis of 5-arylidine Barbituric acid Derivatives Catalyzed by Copper oxide Nanoparticles
... The catalytic activity of the synthesized CuO nanoparticles was investigated in the synthesis of arylidene barbituric acid derivatives at room temperature. To study the efficiency of the CuO ...
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SYNTHESIS OF SOME NOVEL MULTI FLUORINATED BARBITURIC ACID DERIVATIVES
... various Barbituric acid derivatives B1-B12 were carried out by reaction of substituted urea 3a-c with malonic acid to produced compounds 4a-c which on treatment with various aldehydes 5a-d and ...
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Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors
... be the most active members of the series, and showed several fold more urease inhibition activity than the stand‑ ard compound thiourea (IC 50 = 21.2 ± 1.3 µM). Whereas, compounds 4a–b, 4d–e, 4g–h, 4j–4r, 4x, 4z, 5b, 5e, ...
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... A mixture of arylglyoxals 1a-d (1 mmol), 1,3-dimethyl-6-aminouracil (2) (155 mg, 1 mmol) and barbituric acid derivatives 3a-c (1 mmol), TBAB (16 mg, 0.05 mmol) in ethanol (5 ml) was stirred at 50 °C ...
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Buthalital and methitural – 5,5 substituted derivatives of 2 thiobarbituric acid forming the same type of hydrogen bonded chain
... structure of (I) belongs to the C-2 type, which also occurs in a number of 5,5-disubstituted barbituric acid derivatives (Gelbrich et al., 2016a). The four shortest intermolecular contacts of the ...
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Haque, Nadera (2009): Coordination Chemistry of Barbituric Acid, its Diethyl Derivative and Benzildiimine with Transition Metals. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the barbituric acid itself does not possess any hypnotic properties, but such a characteristic is conferred only when the hydrogen atoms at C-5 are replaced by organic groups (alkyl or ...a ...
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Journal of Applied Pharmaceutical Science
... synthesised barbituric acid derivatives by both conventional method and microwave-assisted method was carried out to find out if microwave-assisted synthesis of barbituric acid ...
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One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivatives
... pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of TEA ...
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Thermal and Radiochemical Analysis of Some Nucleic Acid Complexes
... Pyrimidine derivatives constitute an important class of compounds because they are components of the biologically nucleic ...[1]. Barbituric acid derivatives are well-known class of compounds ...
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Synthesis, characterization and docking studies of chromonyl linked meta substituted Benzylidenes as biologically significant partial PPARγ agonists
... (MAA), barbituric acid (BA) and thiobarbituric acid analogues in an effort to develop novel peroxisome proliferator activated receptors ligands partial agonism in the management of hyperglycemia and ...
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Synthesis and antimicrobial activity of chalcones of naphtho[2,1-b]furan condensed with barbituric acid
... Barbitones were synthesized by the condensation of chalcones with barbituric acid. The stuctures of the synthesized compounds assigned on the basis of elemental analysis, IR, 1 H NMR and mass spectral ...
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Synthesis and Characterisation of Novel Knoevenagel condensation product of naphthofuran 2 carbaldehyde with barbituric acid and ethylcyanoacetate
... BA derivatives are well known to possess antibacterial [4], sedatives [5], herbicides [6], fungicides [7], antitumor [8] and antimetastatic activity ...benzylidene derivatives of barbituric acids ...
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N,N Diethylanilinium 5 (2,4 dinitrophenyl) 2,6 dioxo 1,2,3,6 tetrahydropyrimidin 4 olate
... Analytical grade 1-chloro-2,4-dinitrobenzene (2.02 g, 0.01 mol) was dissolved in 20 ml of absolute alcohol. Barbituric acid (1.28 g, 0.01 mol) was also dissolved in 30 ml of absolute alcohol separately. ...
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Barbituric acid metabolism in Nocardia corallina : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University
... Radiochromatogram scans of alcohol extracts of 5 14 0-barbituric acid after incubation with partially-purified barbiturase and cofactors or partiallypurified barbiturase only and treatme[r] ...
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Synthesis of Barbituric and Thiobarbituric Acids Bearing 5,6-Diphenyl-1,2,4-Triazin-3-yl Moiety as CDK2 Inhibitors of Tumor Cells
... and barbituric acids and their related systems, have been synthesis by simple effective methodology by the addition of isocyanate and isothiocyanate to 3-amino-1,2,4-triazine followed by ring closure reactions ...
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Krabbe_unc_0153D_15126.pdf
... temperature of 40 °C. HPLC analysis was performed on an Agilent Technologies 1200 System equipped with Chiralpak IA, IB, and IC columns (constant flow at 1.00 mL/min). Optical rotations were measured using a 2 mL cell ...
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Rubidium 2,4,6 trioxo 1,3 diazinan 5 ide–1,3 diazinane 2,4,6 trione–water (1/1/1)
... acid molecule, a barbiturate anion and one water molecule. The rubidium ion has seven close-contact interactions with O atoms, with Rb O distances ranging from 2.8594 (16) to 3.2641 (14) A ˚ . These seven O atoms ...
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Quinic acid derivatives inhibit dengue virus replication in vitro
... The results showed that we succeeded in transfecting Huh7.5 cell cultures with both replicons and that the concentrations of compounds 2 and 10 that were employed in this assay were non-toxic to Huh7.5 cells. Figure 5 ...
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