Barrier permeability
Alterations in Blood Brain Barrier Permeability in Patients with Systemic Lupus Erythematosus
... blood-brain barrier permeability in rela- tion to perfusion, potentially gaining further understanding of the underlying pathophysiologic mechanisms affecting the brain in patients with ...
8
Application of Blood Brain Barrier Permeability Imaging in Global Cerebral Edema
... CTP data were postprocessed into blood-brain barrier permeability quantitative maps of PS permeability surface-area product, Ktrans volume transfer constant from blood plasma to extravas[r] ...
5
Evaluating Permeability Surface Area Product as a Measure of Blood Brain Barrier Permeability in a Murine Model
... BBB permeability by using PS derived from MR imag- ing ...BBB permeability that could easily be adapted in clinical care, in the mouse brain with known disruption of the ...brain barrier ...
8
Astrovirus Increases Epithelial Barrier Permeability Independently of Viral Replication
... barrier permeability. Here, we demonstrate that astrovirus increases barrier permeability in a Caco-2 cell culture model system following apical ...Increased permeability correlated ...
9
Quantitative imaging assessment of blood-brain barrier permeability in humans
... and permeability quantification are carried out by either using semi-quantitative methods, where statistical differences between scans before and after tracer injection are calculated [8], or by using more quan- ...
8
Non-contrast MR imaging of blood-brain barrier permeability to water
... Blood-brain barrier (BBB) is one of the most important central nervous system (CNS) ...BBB permeability has also been exploited for efficient drug delivery in diseases like brain tumor, lysosomal storage ...
36
Blood-brain barrier permeability and physical exercise
... TJs can be regulated by the activation of various recep- tors of vasoactive compounds (bradykinin and Ang II) as well as adhesion molecules or reactive oxygen species. Intercellular adhesion molecule 1 (ICAM-1), vascular ...
16
Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study
... The relatively high concentration of interstitial water in the periventricular / perivascular regions in combinations with the increasing blood – brain-barrier permeability and plasma le[r] ...
7
Resistance of young gelatinase B–deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions
... Regulated expression of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) plays a role in various physiological processes. To determine in vivo how unbalanced expression of these factors can promote or affect ...
10
EVIDENCE OF A CLOSE RELATIONSHIP BETWEEN GUT MICROBIOTA DYSBIOSIS AND MULTIPLE SCLEROSIS
... intestinal barrier is a functional unit organized in several layers ...surface barrier that hinders bacterial adhesion by preventing its spread in the underlying tissues, a secretory barrier that ...
9
GLIOBLASTOMA MULTIFORME: A REVIEW OF ITS PATHOGENESIS AND TREATMENT
... brain barrier and for this reason, not useful for brain tumour ...brain barrier are under investigation for use in the treatment of GBM as liposome formulations 35 ...
6
Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice
... of barrier perturbation in hairless mice. Acute barrier disruption with acetone results in a 72% increase in epidermal TNF ...of barrier disruption that avoids application of potentially toxic ...
7
Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma
... blood–brain barrier (BBB) restricts the delivery of therapeutic molecules into the brain and offers the clinical efficacy of many pharmaceuticals that have been demonstrated to be effec- tive for other kinds of ...
12
Permeability of Novel Chitosan-g-poly (Methyl Methacrylate) Amphiphilic Nanoparticles in a Model of Small Intestine in Vitro
... To exert its pharmacological activity, orally administered drugs must be absorbed through the intestinal barrier formed by the intestinal mucus and the epithelium [7]. Prediction of the drug absorption plays a ...
21
Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model
... gastrointestinal barrier function and permeability [10,13,16,25-28] and the fact that we observed a strong upregulation of TNF-a expression, it is tempting to speculate, that occludin is a central ...
9
Erythrocyte: Bacteria Killer and Bacteria Pray
... Despite their thicker peptidoglycan layer ( it is relatively porous and so can’t be permeability barrier for reactive oxygen species), gram-positive bacteria are mo[r] ...
7
Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells
... principal permeability barrier, (b) a substantial migration of monocytes occurred in the absence of added chemoattractant when both EC and SMC were present in the coculture, (c) endothelial barrier ...
12
Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival
... Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it. We generated ...
9
Effect of clay type on dispersion and barrier properties of hydrophobically modified poly(vinyl alcohol) bentonite nanocomposites
... vapor permeability at high relative humidity was studied for composite films formed by incorporation of three different bentonites (MMT) clays into an ethylene modified, water- soluble poly(vinyl alcohol), ...
26
Permeability across a novel microfluidic blood-tumor barrier model
... An interesting aspect of our observations was the similarity of efflux function that existed in the microflu- idic model compared to the in vivo BBB [9]. Rhodamine 123 is subject to P-gp mediated efflux at both the BBB ...
10