Bax-induced cell death
Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila
... member Bax is very efficient in inducing apoptosis in Drosophila, allowing the study of bax-induced cell death in a genetic animal ...phenotypes induced by the expression of ...
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Diphenyleneiodonium Inhibits Apoptotic Cell Death of Gastric Epithelial Cells Infected with Helicobacter pylori in a Korean Isolate
... 300:1. Cell via- bility, hydrogen peroxide level, DNA fragmentation, and protein levels of p53, Bcl- 2, and Bax were ...inhibited cell viability with the density of ...pylori-induced ...
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Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX
... tumor cell population to sulindac sulfide may be due to the SRB assay being a measure of total cellular protein (normally proportional to cell number remaining) present after 96-hour drug exposure, and ...
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Murine Cytomegalovirus m38.5 Protein Inhibits Bax-Mediated Cell Death
... stress induced by viral replication within the cells, as well as to stress exerted by exhausted growth medium, toxic secreted factors, or cytotoxic drugs such as STS and ...Premature cell death ...
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Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH2-Terminal Kinase
... 6. Bax translocation, cytochrome c release, and cell death following PV infection depend on JNK ...of Bax translocation from the cytosol to mitochondria by the JNK inhibitor ...for Bax ...
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Jamun (Syzygium cumini (L )): A Review of Its Food and Medicinal Uses
... cancer cell lines MCF-7 (breast), SF-268 (central nervous system, CNS), HCT-116 (colon), and NCI-H460 (lung) [159]; 2) Induce cell cycle perturbations and apoptosis in human cell lines [160]; 3) ...
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SNAP23 regulates BAX dependent adipocyte programmed cell death independently of canonical macroautophagy
... of BAX protein, without any significant effect on other proapoptotic, antiapoptotic, or sensitizer BH3 protein family mem- ...Importantly, BAX knockdown in the context of SNAP23 defi- ciency in vitro ...
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Effect of Farnesyl Caffeate Induced Apoptosis of Lung Carcinoma Cell Line from Damage to DNA
... to Bax. Therefore, the ratio be- tween Bcl-2 and Bax or Bcl-xL and Bax is a decisive factor to activate cell death ...H157 cell treated with Farnesyl caffeate exhibited the ...
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L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
... to cell death [10]. Wild-type DJ-1 represses UV-induced JNK activation to protects cells, but DJ-1(L166P) significantly activates JNK pathway to promote cell death in response to UV ...
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Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis
... irradiation induced Drp1 translocation and mitochondrial fragmentation in both Bax-positive DoHH2/Su-DHL4 cell lines, and Bax- negative Su-DHL10 ...Su-DHL10 cell line is not only ...
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Bee venom inhibits growth of human cervical tumors in mice
... Apoptotic cell death plays an important role in anti- cancer effects of ...of death receptor (DR) expression is implicated in the induction of apoptotic cell death in cancer cells and ...
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Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain
... Interestingly, depletion of galectin-3 significantly reduced spheroid formation, drug resistance and ovarian cancer cell motility. These results strongly suggested that galectin-3 increases the stem-like ...
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The CtBP1-HDAC1/2-IRF1 transcriptional complex represses the expression of the long noncoding RNA GAS5 in human osteosarcoma cells
... types, lncRNAs have also been identified to play roles in osteosarcoma pathogenesis and chemoresistance [6, 7]. For instance, TUG1 (Taurine upregulated gene 1) can repress POU2F1 (POU class 2 homeobox 1) and miR-9-5p ...
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Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L
... inhibitors characterized to date, VACV F1L harbors the most re- stricted proapoptotic Bcl-2 ligand binding profile, making it a suitable candidate for careful dissection of the relative importance of each proapoptotic ...
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Autophagy in cell death: an innocent convict?
... to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-dependent survival and death pathways in clinical ...
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Modulation of innate immunity by nucleotide binding : biochemical and functional characterization of a CATERPILLER_NLR protein, Monarch-1_NLRP12
... The daunting difficulties in the generation and purification of NLR protein impede the biochemical and structural study of NLR protein for years. The complex domain structure and pro-oligomerization nature of NLR ...
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The Role of TIPE2 in the Regulation of Inflammation and Tumorigenesis
... 26 | P a g e Protein regulation occurs when cellular conditions or signaling events dictate a change be made to an already existing protein (Figure 2.2). Certain changes, such as lipid modifications like palmitoylation, ...
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Apoptosis in Murine Norovirus-Infected RAW264.7 Cells Is Associated with Downregulation of Survivin
... any cell culture ...first cell culture system for use in studying the role of apoptosis in NV ...that cell death was associated with activation of caspase-9 and caspase-3 through the ...
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The role of death-associated protein 3 in apoptosis, anoikis and human cancer
... the pro-apoptotic molecules are divided into multi- domain molecules, and BH3-only molecules. A precise model for the relationship between classes of BCL2 mole- cules is yet to be devised, with up to four enumerated by ...
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Regulation of caspase activation during programmed cell death
... programmed cell death, ced-9 (Hengartner et a l, ...the death of cells that normally die during development and mutations that inactivated ced-9 caused cells to die that normally ...
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