Bcl-2
Is Bax/Bcl-2 Ratio Considered as a Prognostic Marker with Age and Tumor Location in Colorectal Cancer?
... carcinogenesis. Bcl-2 protein family, including anti- apoptotic (e.g. Bcl-2, Bcl-xl, and Mcl-1) and pro- apoptotic ...and Bcl-2 genes and Bax/Bcl-2 ratio was ...
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Nuclear factor-kappa B1 inhibits early apoptosis of glioma cells by promoting the expression of Bcl-2
... for 2 h with horseradish peroxidase-conjugated antirabbit secondary antibodies (ProSci, Poway, CA, USA), followed by detection and visualization using electrochemilumi- nescence Western blotting detection reagents ...
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Glutathione and Bcl 2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl xl, bcl 2, and mcl 1
... and Bcl-2 depletion in A375 melanoma ...whereas Bcl-2 levels (B) were measured 24, and 48 h after G4243 ...murine Bcl-2 were quantified by enzyme immunoassay (see Methods) in ...
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Original Article Comparison of Bcl-2, CD38 and ZAP-70 Expression in Chronic Lymphocytic Leukemia
... of bcl-2 expression. Although bcl-2 does not appear to be a major determinant of the differences between the main prognostic subtypes of CLL, these results suggest that BCR signaling and ...
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Immunohistochemical Expression of Bcl-2 and Microvessel Density in Uterine Fibroids in Saudi Patients | WIMJ Open
... of Bcl-2 immunohistochemical expression and the microvessel count as expressed by CD34, aiming to exploit an antibody-based therapy rather than surgical ...of Bcl-2 in controlling the survival ...
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Studying of the Expression of BAX and BCL-2 Genes in Men with Sperm DNA Fragmentation Based on DFI and Comet Assay
... and Bcl-2 de- creases, the suitable pro-apoptotic environment is pre- pared for the cell ...are Bcl-2 family members which exert their regulatory effect on apoptosis through regulation of mi- ...
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Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins
... enhances Bcl-2 expression via integrin/Src signaling. After identifying Bcl-2 as a potential candidate for me- diating long-term survival in HCMV-infected monocytes, we used RT-PCR to confirm ...
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Antiapoptotic Activity of the Herpesvirus Saimiri-Encoded Bcl-2 Homolog: Stabilization of Mitochondria and Inhibition of Caspase-3-Like Activity
... a Bcl-2 homolog are potentially oncogenic, a role of the viral Bcl-2 in tumor formation might be ...cellular Bcl-2 due to a t(14;18) translocation leads to a follicular B-cell ...
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Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer
... infection, Bcl-2 family members display differential ...and Bcl-2 levels increase ...the Bcl-2 family proteins interacts with the E5 oncoprotein; however, there is important ...
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In Silico Molecular Docking Analysis Of Orientin, A Potent Glycoside of Luteolin against BCL 2 Family Proteins
... the BCL-2 family proteins have become an attractive strategy for the treatment of cancer ...apoptotic BCL-2 proteins, such as Bad and Bax and anti-apoptotic BCL-2 proteins, such ...
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Epstein-Barr Virus BALF1 Is a BCL-2-Like Antagonist of the Herpesvirus Antiapoptotic BCL-2 Proteins
... antiapoptotic BCL-2 family members can antagonize the activity of proapoptotic BCL-2 family members and vice versa, though the mechanisms involved are still de- ...lanes 2 and 6), while ...
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Original Article Initiation of premature senescence by Bcl-2 in hypoxic condition
... of Bcl-2 in mouse melanoma B16 cells. In CoCl 2 -simu- lating hypoxic condition, characteristic morphological alterations and increased activity of senescence-associated β-galactosidase (SA-β-gal) ...
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A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2
... investigating Bcl-2′s dual anti- apoptotic mechanisms and the effects of targeting these mechanisms with either BIRD-2 or BH3 mimetic agents alone, or in ...target Bcl-2-IP 3 R ...
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Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?
... protein 2 (Bcl-2)-associated X (Bax) and Bcl-2, act as a promoter and an inhibitor of apoptosis, ...and Bcl-2 as well as their ratio have been regarded as prognostic ...
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Cyclin I activates Cdk5 and regulates expression of Bcl 2 and Bcl XL in postmitotic mouse cells
... proteins Bcl-2 and Bcl-XL were reduced in podocytes and neurons from cyclin I–deficient mice, and restora- tion of Bcl-2 or Bcl-XL expression prevented injury-induced ...and ...
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Expression of Bcl 2 and Bcl 2 Ig fusion transcripts in normal and neoplastic cells
... the Bcl-2 gene at chromosome segment 18q21, that is translocated into the Ig heavy chain gene locus in t(14;18) bearing ...lymphomas. Bcl-2, while B cell associated, is expressed in a variety ...
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BCL-2 as therapeutic target for hematological malignancies
... between BCL-2-family proteins and hematologic malignancies is well ...of BCL-2, such as veneto- clax and navitoclax, were shown to selectively induce apoptosis in malignant cells and have been ...
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BIOACTIVE COMPOUNDS TO TARGET ANTI APOPTOTIC PROTEINS Bcl 2 AND Bcl XL AN IN SILICO APPROACH
... ABSTRACT: Phytochemicals from several herbaceous and spice plants have been reported to have defense properties against various diseases. Potential of some of such plants like Allium sativum, Curcuma longa, Boerhaavia ...
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Antiapoptotic Herpesvirus Bcl-2 Homologs Escape Caspase-Mediated Conversion to Proapoptotic Proteins
... cellular Bcl-2 family mem- bers. The mammalian Bcl-2 family is defined by the homology domains BH1 to ...herpesvirus Bcl-2 homologs ...a 2-nucleotide insertion at posi- ...
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Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB pathways in cholangiocarcinoma cells
... In summary, our study showed that CTS is a potent growth inhibitor of CCA cells in vitro and in vivo. Growth inhibition of CCA by CTS was time and dose dependent and related to S-phase arrest. CTS also caused a marked ...
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