Bcl-2 family protein
Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax
... containing 2% CHAPS, a detergent that does not arti- ficially affect the conformation of Bcl-2 family proteins (34, ...63). Bcl-x L , a cellular Bcl-2 family ...
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Bax promoter G(－248)A polymorphism in a Turkish clinical breast cancer patients: A case control study
... by Bcl-2 family proteins that control the mito- chondrial release of death factors such as cytochrome c, AIF, Smac/DIABLO and endonuclease C ...× protein) protein is one of the proapo- ...
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COMPUTATIONAL PREDICTION OF PROTEIN INTERACTIONS IN BCL 2 PROTEIN AND THEIR ROLE IN APOPTOSIS
... target protein and drug ability of ...work protein functional region among mammals along with their interactions were studied in mitochondrial mediated ...proteins, Bcl-2 family of ...
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Human Cytomegalovirus Promotes Survival of Infected Monocytes via a Distinct Temporal Regulation of Cellular Bcl-2 Family Proteins
... antiapoptotic protein Mcl-1 ...the protein as a member of the Bcl-2 family of mitochondrial membrane perme- ability regulators and defined a dual role for Mcl-1 in myeloid cells: ...
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The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma
... BAX: Bcl-2-associated X protein; BCL-2: B-cell lymphoma 2; bHLH: Basic-helix-loop-helix family of proteins; BMP: Bone morphogenic protein; CGNP: Cerebellar granule ...
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The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function.
... the Bcl-2 family often lies at the heart of many diseases, the development of molecular tools, which help dissect the pathways involved, is of paramount ...full-length protein) as the mediator ...
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New dimension in therapeutic targeting of BCL-2 family proteins
... targeting BCL-2 family proteins is considered to have a promising therapeutic potential especially for treating cancers [1, 2, ...prosurvival BCL-2 family proteins ...
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TEACHING PROTEIN SCIENCE WITH APPLICATION OF COMPUTERS – CASE STUDY OF BCL-2 PROTEIN FAMILY
... G protein-coupled receptors (GPCRs), nuclear receptors, ligand-gated ion channels and voltage-gated ion ...of protein structures and the design of ligands which modulate their activity an essential skill ...
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BCL W has a fundamental role in B cell survival and lymphomagenesis
... investigated BCL-W in DLBCL with respect to BCL-2, a known contributor to DLBCL that, when overexpressed, correlates with reduced patient survival (5, ...both BCL-W and BCL-2 ...
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Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate Against TBHP-Induced Oxidative Damage in SH-SY5Y Cells
... the protein expression changes of the Bcl-2 family and the activation of caspases ...The Bcl-2 family proteins are key components of the cascade reaction of mediated ...
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Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis
... the Bcl-2 family are pivotal mediators of this ...Asfarviridae family, and harbors A179L, a putative Bcl-2 like ...proapoptotic Bcl-2 proteins; however, the ...
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The role of BCL 2 protein family in the development of the peripheral nervous system
... minutes and aspirating the supernatant. After alkaline lysis, plasmid DNA was purified away from chromosomal DNA, protein and RNA by ultracentrifugation on a Caesium chloride/ ethidium bromide gradient. In this ...
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Investigation of the regulation of Bcl 2 family members in apoptosis and cancer
... A1 Bcl-2 related protein-A1 AIDS Acquired immune deficiency syndrome AMPK Adenosine monophosphate-activated protein kinase AP1 Activator protein 1 Apaf-1 Apoptotic protease activating fa[r] ...
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Original Article Repair of spinal cord injury in rats by subarachnoid transplantation of genetically modified schwann cells
... with bcl-2 ...lymphoma 2 gene (bcl-2 gene) using Ad-EGFP (Enhanced Green Fluorescent Protein) ...and bcl-2 gene transfection group. The bcl-2 gene ...
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Emerging role for members of the Bcl 2 family in mitochondrial morphogenesis
... this family involved in mitochondrial morphogen- esis, as well as ...the Bcl-2 family play roles in mitochondrial morphogenesis that are functionally distinct from their role as regulators of ...
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Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemia
... of Bcl-2 associate with a low complete remission rate after intensive chemotherapy and with a significantly shorter survival of AML patients ...of Bcl-2 overexpression may due to chromosomal ...
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PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway
... including Bcl-2, Bax, Caspase-9, Caspase-3, and cleaved-PARP, was determined by Western blotting ...of Bcl-2 protein was downregulated and that of Bax, Caspase-9, Caspase-3, and ...
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Apoptosis in cancer: from pathogenesis to treatment
... Many studies have investigated various approaches tar- geting Survivin for cancer intervention. One example is the use of antisense oligonucleotides. Grossman et al was among the first to demonstrate the use of the anti- ...
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Activation of the Unfolded Protein Response Enhances Motor Recovery after Spinal Cord Injury
... the BMS subscore was analyzed, which reveals finer aspects of locomotor function, observing a significant difference in the locomotor recovery of mice injected with XBP1s AAVs between 14 and 35 days after SCI (Figure 5c ...
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ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun
... the protein expression level of ANXA11 in Hca-P was 2-fold higher than Hca-F cells [39], suggesting ANXA11 might act as a potential suppressor for the lymphatic metastasis of murine ...
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