Bcl-x
Signals through gp130 upregulate bcl x gene expression via STAT1 binding cis element in cardiac myocytes
... Site-directed mutagenesis. Site-directed mutagenesis was carried out according to instructions (LA PCR in vitro mutagenesis kit; TaKaRa Shuzou). In brief, the promoter region of the bcl-x gene was inserted ...
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Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-x(L)
... the Bcl-x Promoter in Vitro and in Vivo—The ability of GR to bind to the identified GRE sequences was examined by gel mobility shift ...the Bcl-x ...
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Expression of apoptosis related genes bax, bcl-2 and bcl-X in human gastric cancer: early results of an investigation
... tissue. Bcl-2, bax and bcl-X L genes expression at mRNA level were classified as normal, increased or decreased on the basis of the established ...bax, bcl-2 and bcl-X proteins ...
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N52 monodeamidated Bcl‑x shows impaired oncogenic properties in vivo and in vitro
... disabling Bcl‑x L binding to pro‑apoptotic BH3‑only partners like Bim and Puma ...entails Bcl‑x L deamidation ...of Bcl‑x L cellular amount since the deamidated protein is ...
15
Homoharringtonine regulates the alternative splicing of Bcl x and caspase 9 through a protein phosphatase 1 dependent mechanism
... of Bcl-x and caspase 9 pre-mRNA in breast cancer MCF7 cells We explored the effects of some natural products on the alternative splicing of Bcl-x using semi-quantitative RT-PCR in MCF7 ...the ...
11
Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X
... using Bcl-X pre-mRNA, and show that well- known DNA G4-stabilizers produce diverse ...anti-apoptotic Bcl-XL isoform to the pro-apoptotic Bcl-XS isoform, while others have no effect on ...of ...
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Relevance of Bcl-x expression in different types of endometrial tissues
... that Bcl-xl protein expression had matched pattern with expression of Bcl- xl mRNA in different types of endometrial tissues, For example, these two were positively correlated ( r = ...of Bcl-xl and ...
7
PubMedCentral-PMC4992517.pdf
... apoptosis. Bcl-x, an antiapoptotic member of Bcl-2 gene family, plays a role in apoptosis regulation in mammalian ...the Bcl-x gene yields two major protein isoforms with opposing ...
7
Antiapoptotic Activity of the Herpesvirus Saimiri-Encoded Bcl-2 Homolog: Stabilization of Mitochondria and Inhibition of Caspase-3-Like Activity
... may block cell death differentially in some systems (18, 52). Possible biological role of HVS-Bcl-2. Two kinds of apopto- tic stimuli that eventually lead to apoptosis of virus-infected cells can be distinguished. ...
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Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
... To identify potential G4s within this structure, we replaced all guanines by 7-deaza-G during in vitro transcription. The absence of the N7 in the 7-deaza-G was shown previously to abolish the possibility of Hoogsteen ...
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Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death
... of Bcl-2 family mem- bers, promoting or inhibiting this process ...tent BCL-2 homology (BH) 3-only molecules, in terms of cell killing [18], and has also clearly overlapping func- tions in p53-dependent and ...
13
Role of passive T cell death in chronic experimental autoimmune encephalomyelitis
... a family of genes that modulate programmed cell death or apoptosis. The function of these genes is critical not only during development and tissue homeostasis, but also in the pathogenesis of a variety of diseases ...
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Analysis of caspase-3 enzyme marker expression in oral squamous cell carcinoma: An Immunohistochemical study
... -2, Bcl-x, Bcl-x L, Bcl -2-relat ed protei n A1, BAG -1, and survivin) and prom otion (Bak, Bax, Bi m/Bod, Bim -Long, Bad, Bi d, PUMA, Apaf -1, cas pas e-2, caspas e -3, cas pas e -6, ...
85
Determining the impact of alternative splicing events on transcriptome dynamics
... of Bcl-xS SSO on specific cellular func- tions or pathways was ...of Bcl-xS SSOs on the repression of ribosomal protein-encoding genes and genes that code for nucleic acid binding ...by Bcl-x ...
9
The antiapoptotic protein Bcl xL negatively regulates the bone resorbing activity of osteoclasts in mice
... the Bcl-x cKO mice grew normally with no appar- ent morphological abnormalities, they developed substantial osteopenia at 1 year of age, which was caused by increased bone ...resorption. Bcl-x ...
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Geisenhof, Stefanie (2007): Die Bedeutung von Mutationen der Rezeptortyrosinkinase FLT3 für die Resistenzentstehung in der akuten myeloischen Leukämie. Dissertation, LMU München: Medizinische Fakultät
... der bcl-2 Gene, die für die Regulation des Apoptoseprozesses verantwortlich ...der Bcl-2 Familie einen Einfluss auf die zytostatikainduzierte Apoptose hat und daraus folgend zu Resistenzen ...von ...
65
Novel targeted deregulation of c Myc cooperates with Bcl XL to cause plasma cell neoplasms in mice
... cell tumors demonstrated proclivity to bone marrow involvement, generating coalescent, wall-to-wall tumor masses in several mice with terminal neoplasia (Figure 6A). Histological examination of bone sections from mice ...
12
L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
... L166P mutant prevents normal folding of wild-type DJ-1 and itself is instable with a rapid degradation via UPS [6,7,51,52]. However, DJ-1(L166P) appears not only to be “loss of function” of wild-type DJ-1. It also forms ...
11
RETRACTED ARTICLE: The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induced by paclitaxel
... of Bcl-XL and survivin mRNAs were up-regulated by the pre-treatment of DEX (p < ...of Bcl-2 mRNA was un-affected by DEX pre-treatment (p > ...expressions, Bcl-XL protein was up-regulated by DEX ...
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<p>Grape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3K/Akt signaling pathway</p>
... of Bcl-2 and Bcl-xl, allowing the free Bcl-2 to exert its anti-apoptotic effect and directly catalyze the inactivation of Caspase-3 and Caspase-9 at Ser196, and fi nally promote the proliferation and ...
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