Bcl2/Bax
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway
... Seven days after the surgery, six mice in each group were deeply anesthetized with an overdose of 3.5% chloral hydrate (0.1 mL/10 g, i.p), and transcardially perfused with 0.9% NaCl solution to rinse out the blood, ...
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Quantitative Analysis of Expression Level of BCL2 and BAX Genes in Hep-2 and HL-60 Cells after Treatment with Etoposide
... genes BCL2 and BAX in Hep-2 and HL- 60 ...of BCL2 and BAX genes were measured after 6 h and 12 h of treatment by quantitative real-time ...of BCL2 significantly increased both 6 h and ...
5
PROGNOSTIC VALUE OF BCL2 ASSOCIATED X PROTEIN (BAX) EXPRESSION IN ADULT EGYPTIAN PATIENTS WITH ACUTE MYELOID LEUKEMIA
... [2] groups, to allow tailoring of treatment strategies. Understanding of the molecular pathways that participate in the biology of leukemia may lead to the design of new therapies which may improve patients' survival ...
7
Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells
... Interestingly, Bax and Bcl2 responded differently to the drug in a cell type dependent ...of Bcl2 expres- sion in HepG2 and HCT116 cells strongly decreased time-dependently after 24 and 48 ...of ...
9
Impact of TGIFLX Expression on the Regulation of BCL2 and BAX in Prostate Cancer Cell Line (LNCaP)
... of BCL2 and BAX genes ...of BAX gene at the mRNA level was increased in the LNCaP cells harboring Ad-TGIFLX-GFP vector but not in the controls ...
9
ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells
... With TRI reagent (Sigma-Aldrich), total RNA was extracted from HaCaT cells according to the manufacturer’s instruc- tions. Quantification of total RNA was determined at 260 nm by nanodrop spectrophotometry (ND-1000; ...
9
Original Article Geniposide protects against spinal cord injury in rats through attenuating the regulation of inflammatory response and the Bcl2/Bax pathway
... nology, Santa Cruz, CA, USA). Equal quantities of 60 µg protein were fractioned on 10% so- dium dodecyl sulfate-polyacrylamide gels (Mi- llipore, Bedford, MA, USA), transferred onto nitrocellulose fluoride membranes ...
8
SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner
... However, the expression of SIRT3, p-AMPK/AMPK, Mfn1, Mfn2, and Bcl2/Bax significantly increased after HKL administration (Fig. 5 a, b, P <0.05), suggesting that HKL activated the SIRT[r] ...
8
The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary
... for BCL2, BAX and VASA; 20 μg for MCL-1 and cleaved-BID) from tissue extracts were separated by one-dimensional SDS-PAGE (10% for MCL-1 and VASA; 12% for BCL2, BAX and cleaved-BID) and then ...
16
Clinicopathologic evaluation of Pro- and antiapoptotic marker expression in oral squamous cell carcinoma
... i.e bcl2, bax, p53 and MIB-1 in 111 H&N SCC patients who were concurrently treated with ...between bcl2 and local regional control and also between MIB-1 and overall ...of bcl2 is ...
89
Original Article The protective effect of the Rho-kinase inhibitor hydroxyfasudil on propofol-induced hippocampal neuron apoptosis in neonatal rats
... The rats were sacrificed by decapitation under deep anesthesia 24 h after the last injection, and the hippocampi were isolated immediately for the detection of neuronal apoptosis using a TUNEL assay (n = 5) and the ...
9
Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death
... In mammalian cells the two major apoptotic pathways are the ‘’intrinsic’’ pathway, involving mitochondrial membrane permeabilisation regulated by the members of the Bcl2/Bax protein fami[r] ...
15
<p>Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis</p>
... g for 20 min. Next, the supernatant was taken, and the protein concentration was determined by BCA kit (Thermo Fisher). Having separated by SDS-PAGE, the isolated protein was transferred to polyvinylidene fl uoride ...
12
Molecular mechanisms of HPV mediated neoplastic progression
... protein; Bax: BCL2-associated X protein; BRCA1: Breast cancer type1; BRD4: Bromodomain-containing protein4; CADM1: Cell adhesion molecule 1; CCNA1: Cyclin-A1; CDKs: Cyclin-dependent kinases; CEBPB: ...
11
Molecular pattern of lncRNAs in hepatocellular carcinoma
... factor; BAX: BCL2-associated X protein; BRM: Brahma; CAMTA1: calmodulin binding transcription activator 1; c-CBL: casitas B- lineage lymphoma; ceRNA: competing endogenous RNA; CHIP: Carboxy- Terminus of ...
15
Original Article Identification of genes associated with apoptosis-sensitive acute lymphoblastic leukemia responsive to ionising radiation by bioinformatics analyses
... as BCL2-associated X protein (BAX) and Fas cell surface death receptor (FAS), were mainly enriched in the BP terms related to apoptosis and p53 signaling ...including BAX, FAS, CCND3 and CD40 may be ...
6
Protective Effects of Flavonoid Baicalein against Menadione Induced Damage in SK N MC Cells
... Oxidative damage and redox metal homeostasis loss are two contributing factors in brain aging and widely distributed neurodegenerative diseases. Oxidative species in company with excessive amounts of intracellular free ...
10
More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells
... BAK: BCL2 homologous antagonist/killer; BAX: BCL2-associated X apoptosis regulator; BBB: Blood-brain barrier; BCL: B cell lymphoma; CCU: Color-changing units; CNS: Central nervous system; CytC: ...
13
Low BCL9 expression inhibited ovarian epithelial malignant tumor progression by decreasing proliferation, migration, and increasing apoptosis to cancer cells
... apoptosis-promoting BCL2 protein decreased, with no changes in the expression of apoptosis-related BAX ...The BAX/BCL2 expression ratio significantly increased ...the BAX/BCL2 ...
16
Cardiac Effects Of Huntington’s Disease In Murine Models
... Stressed hearts from both WT and HD mice have increased Bax expression and decreased Bcl2 expression relative to unstressed hearts of the same genotype, suggesting that stress prom[r] ...
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