BCR, B cell receptor
Identification of LCK as a key mediator of B cell receptor (BCR)signalling in chronic lymphocytic leukaemia (CLL)
... on BCR signalling than CLL cases carrying high CD22 and low ...by BCR crosslinking, and suggest that Lck is responsible for this ...in BCR signalling in CLL ...
197
Targeting CD22 with the monoclonal antibody epratuzumab modulates human B cell maturation and cytokine production in response to Toll like receptor 7 (TLR7) and B cell receptor (BCR) signaling
... protocol. Cell suspen- sions were prepared by gently teasing tissues in R10 medium (RPMI 1640 containing 10% FBS (ThermoFisher Scientific), 100 U/ml penicillin, 100 mg/ml streptomycin, 2 mM L -glutamine, 1 mM ...
18
Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross sectional study
... BAFF: B cell activating factor; BCR: B cell receptor; CpG: cytosine-phopsphate-guanosine; DC: dendritic cell; DCregs: indoleamine 2,3-dioxygenase-expressing dendritic ...
18
Generation mechanism of RANKL+ effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis
... antibodies; BCR: B-cell receptor; cDNA: Complementary DNA; ctsk: Cathepsin K; CXCL10: CXC motif chemokine ligand 10; CXCR3: CXC motif chemokine receptor 3; FcRL4: ...
10
STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial
... CDKN2A/ B (Additional file 1: Table S1). CD79B is a subunit of the B-cell-receptor (BCR) and has been implicated as an oncogenic driver, primarily in activated B-cell ...
10
Practical guidelines for B-cell receptor repertoire sequencing analysis
... of B cells in each ...same cell, or multiple cells expressing the same ...independent cell, this provides a lower bound on diversity and other repertoire ...different cell subsets can express ...
14
STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia
... the B cell receptor (BCR) Ca 2+ pathway has been associated with disease progression, the importance of the newly described constitutive Ca 2+ entry (CE) pathway is less ...transient ...
13
Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial
... the B-cell receptor (BCR) which is expressed at low levels on CLL ...cells. BCR activation leads to the transduction of signals through a series of intracellular molecules resulting in ...
10
Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation
... memory B cells following primary infection (1–3). The disappearance of B cells from blood as assessed by flow cytometry following treatment with a B cell-targeting monoclonal antibody commonly ...
13
The role of B cell antigen receptors in mantle cell lymphoma
... a B cell is the expression of a BCR and, upon its terminal differ- entiation into a plasma cell, the secretion of highly spe- cific ...All B cells keep expressing their clone-specific ...
12
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
... β cell dys- function (Supplemental Table ...distinct receptor distributions among various ...T cell receptor β chain (TRB) and B cell receptor (BCR) immunoglobulin ...
20
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells
... regulatory B cells (B10 cells) [24-27] which require for their formation BCR engagement and activation via the CD40 molecule or LPS stimulation ...However, B cells can also contribute to or induce ...
13
The Role of STAT3 in the Pathogenesis of Chronic Lymphocytic Leukaemia
... chemokine receptor signalling pathways and integrin activation, which function in cell migration and adhesion (de Gorter et ...normal B cells, activation of MAPK pathways leads to the phosphorylation ...
250
B cell antigen receptor-induced activation of an IRAK4-dependent signaling pathway revealed by a MALT1-IRAK4 double knockout mouse model
... Toll-like receptor; AgR: antigen receptor; BAFF: B cell activation factor of the TNF family; BCR: B cell AgR; TCR: T cell AgR; PRR: pathogen recognition ...
9
Development of prophylactic vaccines against HIV 1
... T cell responses targeting a median of one epitope per protein, with a bias towards less conserved epitopes ...T cell responses would be needed to contain early viral ...
16
Use of V(D)J recombination excision circles to identify T and B cell defects and to monitor the treatment in primary and acquired immunodeficiencies
... and B-cell functions, HSCT recipients are more prone to in- fections and relapse of malignancies [81,82], and the risk of developing these complications notably correlates with the recovery of CD4 + T cells ...
11
Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing
... T cell transfusion using cancer antigen-specific T cells is the most effective immunotherapy ...antigene receptor (CAR)-T cells, TCR-engineered T cells have emerged from pre-clinical research to clinical ...
8
DNA ligase IV syndrome; a review
... factors include intracellular events such as DNA replica- tion and meiosis, and extracellular events including damage by reactive oxygen species and ionising radi- ation. In order to maintain genomic integrity and ...
7
Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients
... reactive B cell populations, including anti-DNA Ab-bear- ing B cells occurring in SLE patients ...of B lymphocytes containing the 9G4 idio- type in their surface Ig was examined in the blood ...
10
Design, Synthesis and Anticancer Screening of Novel Piperidine ydroxamate as HDAC Inhibitors.
... the receptor, the orientation is ...the receptor are scored (subset ...the receptor are scored (Step ...the receptor but also on the best possible score it could get by moving ±1 Å in x, y, or ...
105