Beclin-1
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
... The beclin 1 autophagy gene is monoallelically delet- ed in 40–75% of cases of human sporadic breast, ovarian, and prostate ...of beclin 1 promotes ...of beclin 1 increases the ...
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Antitumor Effects of HPV DNA Vaccine Adjuvanted with Beclin-1 as an Autophagy Inducer in a Mice Model
... with Beclin-1, as a novel adjuvant system, in mice immunized with human papilloma virus (HPV) DNA ...with Beclin-1 enhances the efficacy of HPV DNA vaccine, female C57BL/6 mice were challenged ...
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Prognostic relevance of autophagy related markers LC3, p62/sequestosome 1, Beclin 1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status
... Only few studies on p62 and colorectal cancer have been published thus far. In a recent study on 178 colon carcinomas treated with adjuvant 5-FU, Beclin-1 overex- pression (but not p62) was significantly ...
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Characterization of apoptosis and autophagy through Bcl-2 and Beclin-1 immunoexpression in gestational trophoblastic disease
... of Beclin-1 protein in GTD and normal placenta was also ...studied. Beclin-1 is a gene in mammals that was first identified to have a role in controlling autophagy ...Therefore, ...
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Myeloid loss of Beclin 1 promotes PD L1hi precursor B cell lymphoma development
... (1). Beclin 1 (Becn1) acts as a core component of the class III phosphatidylinositol 3-kinase Vps34 complex, which is critical for the initiation of autophagy and autophagosome formation ...
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Original Article The role of autophagy and Beclin-1 in radiotherapy-induced apoptosis in thyroid carcinoma cells
... To understand the role of autophagy in RT- induced TC cells apoptosis, autophagy level was quantified by FACS following MDC staining. X-ray irritation induced an increase of MDC positive SW579 cell population, which was ...
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Prognostic and clinicopathological significance of Beclin-1 in non-small-cell lung cancer: a meta-analysis
... of Beclin-1 in ...of Beclin-1 was associated with a better prognosis in ...of Beclin-1 was significantly cor- related with earlier tumor grade, lower nodal involvement, earlier ...
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Ferroferric oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin 1/Bcl-2/VPS34 complex
... that Beclin 1, VPS34, and Atg14 were induced while the Bcl-2, a negative modulator of Beclin 1, was decreased by these NPs (Figure ...and Beclin 1 after cells were treated for 3 ...
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The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1
... with Beclin 1 ...with Beclin 1 (47, ...with Beclin 1, because vBcl-2 does not have the N-terminal loop that contains amino acid sub- strates for JNK and thus cannot be ...
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Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB
... of Beclin-1 in three independent and publicly available breast cancer datasets—TCGA, UNC, and ...low Beclin-1 expression correlated with reduced overall and recurrence-free survival in ...
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Original Article Over expression of GPR30, indicating poor prognosis and promoting proliferation, upregulates Beclin-1 expression via p38MAPK signaling in esophageal squamous cell carcinoma progression
... and Beclin-1 protein expres- sion in every group, we found that Beclin-1 was highly expressed in G-1 group, and was consis- tent with GPR30 expression, but was blocked by the p38MAPK ...
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Interaction of ICP34.5 with Beclin 1 Modulates Herpes Simplex Virus Type 1 Pathogenesis through Control of CD4+ T-Cell Responses
... type 1 (HSV-1) infection induces an autophagy response, but this response is antagonized by the HSV-1 neuroviru- lence gene product, ...protein Beclin 1 (Atg6) via the ...
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Beclin-1 regulates cigarette smoke–induced kidney injury in a murine model of chronic obstructive pulmonary disease
... of Beclin-1 and LC3B in murine kidneys after UUO, a model of kid- ney fibrosis (42), whereas in the current study, we observed decline in the kidney expression of LC3B or Beclin-1 after ...
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Original Article Expression of glucose transporter-1, hypoxia inducible factor-1α and beclin-1 in head and neck cancer and their implication
... cancer, beclin-1 expres- sion was strongly expressed in carcinomas with a lack of necrosis, and strong GLUT-1 expression was found in advanced ...of beclin-1 was also found to be ...
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Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia
... of Beclin-1 gene was amplified by PCR by using the upstream primer (5’- CCG GAA TTC ACC ATG GAA GGG TCT AAG ACG TCC AAC-3’) and downstream primer (5’-ACG CGT CGA CTT ATC ATT TGT TAT AAA ATT GTG AGG- ...
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Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
... sphere, 1 μl volume was injected stereotaxically at a rate of 100 nl/min using a 5 μl Hamilton ...recovery. Beclin 1 vi- ruses (Beclin-AAV) were stereotaxically injected into one hippocampus ...
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The Expression of Beclin-1 in Hepatocellular Carcinoma and Non-Tumor Liver Tissue: A Meta-Analysis
... Recently, Beclin-1 expression in hepatocellular carcinoma (HCC) and non-tumor liver tissue have been investigated by several ...of Beclin-1 in the occurrence of HCC by comparing the difference ...
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Regulation of Aβ pathology by beclin 1: a protective role for autophagy?
... that beclin 1, a multifunctional protein that also plays an important role in the autophagy pathway, affects some aspects of Ab pathology in aged but not young transgenic mice expressing amyloid precursor ...
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Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1
... that Beclin-1 acetylation was decreased in acetyl-lysine immunoprecipitate fractions after ω-3 PUFA supplementation compared with the TBI ...of Beclin-1 and autophagy activa- tion induced by ...
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Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia
... sc-21712; 1:100 dilution) or control IgG (Santa Cruz Biotechnology, sc-2025) was then added to the lysate and incubated at 4°C for 1 ...anti–mouse Beclin 1 antibody (Santa Cruz Biotechnolo- ...
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