bench-to-bedside
MEK and the inhibitors: from bench to bedside
... Four distinct MAPK cascades have been identified and named according to their MAPK module. These are extra- cellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), p38 and ERK5. Each of these cascades ...
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Malignant pleural effusion: from bench to bedside
... During the last decade, there has been significant progress in unravelling the pathophysiology of MPE, as well as its diagnostics, imaging and management. Expanding interest in this area has resulted in an increasing ...
10
Linagliptin: from bench to bedside
... Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab[r] ...
16
Bench to bedside review: Recruitment and recruiting maneuvers
... Brower RG, Morris A, MacIntyre N, Matthay MA, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D; ARDS Clinical Trials Network, National Heart, Lung, and Blood Institute, National [r] ...
6
Targeting the IDO1 pathway in cancer: from bench to bedside
... High IDO-1 expression in tumor endothelial cells is associated with response to immunotherapy in metastatic renal cell carcinoma. Patel SA, Minn AJ[r] ...
12
Systemic treatment for lung carcinoids: from bench to bedside
... The SPINET trial (NCT02683941) is a phase 3, randomized, double-blind study evaluating efficacy and safety of lanreotide vs pla- cebo in patients with advanced TCs and ACs, whereas AT[r] ...
19
TRANSLATION MEDICINE AND BIOMARKERS; BENCH TO BEDSIDE — AN OVERVIEW
... One prevalent description of translational medicine, first introduced by the Institute of Medicine's Clinical Research Round table, highlights two road- blocks (i.e., distinct areas in [r] ...
5
Angiotensins and Alzheimer's disease: a bench to bedside overview
... A β = amyloid β peptide; ACE = angiotensin-1 converting enzyme; ACE-I = ACE inhibitor; ACh = acetylcholine; AD = Alzheimer’s disease; Ang = angiotensin; APP = amyloid precurser protein;[r] ...
8
Heritable pulmonary hypertension: from bench to bedside
... In the latest European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines [39], patients carrying a mutation in a PAH-predisposing gene (BMPR2 and/or other mutatio[r] ...
9
Heterogeneity of colon cancer: from bench to bedside
... 14 The population of commensal bacteria is different in RCC and LCRC both quantitatively and qualitatively and this difference induces changes in the intestinal epithelial cells as w[r] ...
8
Bench to bedside review: Chloride in critical illness
... In older patients undergoing major surgery, a lower chloride load from a lactated solution or 6% hetastarch in balanced solution Hextend® again led to greater urine output compared with [r] ...
10
Bench to bedside review: Ventilatory abnormalities in sepsis
... In a study with markedly increased ventilator activity caused by oleic acid induced lung injury but normal cardiac function [29], total ventilator muscle flow accounted for 11% of total [r] ...
12
Bench to bedside review: Clostridium difficile colitis
... Warny M, Pepin J, Fang A, Killgore G, Thompson A, Brazier J, Frost E, McDonald LC: Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe dis[r] ...
8
Bench to bedside review: Rhabdomyolysis – an overview for clinicians
... By definition, patients with heat stroke have a core body temperature in excess of 40.5°C and their course is often complicated by acute respiratory distress syndrome, disseminated intra[r] ...
12
Bench to bedside review: Resuscitation in the emergency department
... Metabolic acidosis and lactic acidosis are byproducts of anaerobic metabolism, and when they are measured in serum they can be useful markers of persistent tissue hypoxia or oxygen debt. Rapid bedside ...
7
Bench to bedside review: Sepsis is a disease of the microcirculation
... depends on trans- or epi-illumination and thus observations are limited to superficial layers of thin tissues only. By using fluorescent dyes a higher contrast is possible as well as labelling specific cells for ...
7
B7x—from bench to bedside
... Cancer: Several observational studies show that the B7x protein is selectively expressed in higher levels in cancers including ovarian, renal cell cancer, pancreatic cancer, hepatocel[r] ...
5
Circulating microRNAs in malaria infection: bench to bedside
... The knowledge of miRNAs as possible disease biomarkers in blood is a promising breakthrough especially the patients with malaria infection.. For practical use, the disease criteria for s[r] ...
8
B-Raf and the inhibitors: from bench to bedside
... thyroid carcinoma. Additionally, there is sub- stantial evidence showing V600E mutation in classic PTC, but not with follicular thyroid carcinoma and medullary thyroid carcinoma [24-26].[r] ...
9
Bench to bedside review: Carbon dioxide
... The potential for hypercapnia to directly contribute to the beneficial effects of protective lung ventilatory strategies is clear from experimental studies demonstrating protective effects [r] ...
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