Bergmann glia
PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization
... between Bergmann glial scaffold and granule neuron is vital for granule neuron migration and IGL ...in Bergmann glia by targeted adenovirus injection in vivo at P3, prior to the peak of granule ...
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Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development
... Thyroid hormone is necessary for normal development of the central nervous system, as shown by the severe mental retardation syndrome affecting hypothyroid patients with low levels of active thyroid hormone. The ...
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ERBB3 mediated regulation of Bergmann glia proliferation in cerebellar lamination
... of Bergmann glia (BG), which extend unipolar processes to contact the pial membrane and are important for cerebellar lamination (Rakic, ...the glia limitans (formed by BG end feet) and migrate along ...
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Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
... in Bergmann glia, but not in Purkinje cells and microglia by co-staining analyses using an antibody recognizing only the human IKK2 derived transgene to- gether with the astrocyte marker Aldh1l1 ...in ...
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Sørensen, Jonna (2007): Untersuchungen zur Funktion von Thioredoxin Reduktase 1 in der ZNS-Entwicklung in konditionalen Knockout-Mäusen. Dissertation, LMU München: Tierärztliche Fakultät
... Retardation der Fissuren-Bildung sichtbar und setzt sich in der postnatalen Kleinhirn- Entwicklung fort. Die Knockout-Tiere bleiben in der Gewichtsentwicklung hinter den Kontroll-Tieren zurück und weisen eine massive ...
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Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology
... a Bergmann glia cell from a Gfa2-CGG11 transgenic mouse which has the characteristic morphology of Berg- man glia (small arrows point to radial ...in Bergmann glia from Gfa2-CGG11 ...of ...
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Radial glial cells: Key organisers in CNS development
... in glia (Choi, 1981; Levitt & Rakic, ...radial glia are thought to persist into adult life, albeit in very limited numbers, and some in specific neurogenic ...Radial glia subtypes have also been ...
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Ocasio_unc_0153D_18979.pdf
... WNT pathway suppression by GSK-3 may be necessary in Purkinje neurons and Bergmann glia Additionally, while our studies demonstrate an endogenous function of GSK-3 in CGNP development,[r] ...
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Cell death and clearance in young animals
... the Bergmann glia, strongly suggesting that digestion was taking place in situ in the EGL, rather than pyknoses being retracted into the main soma, as often occurs in ...f Bergmann glial processes ...
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Immunohistochemical localization of apolipoprotein E in human glial neoplasms
... Immunocytochemical analyses revealed the presence and distribution of apolipoprotein E (apo E) in normal human brain tissue as well as in 77 human intracranial neoplasms. In normal brain tissues, the perikarya of ...
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Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
... The plasma protein apolipoprotein (apo) E is an important determinant of lipid transport and metabolism in mammals. In the present study, immunocytochemistry has been used to identify apo E in specific cells of the ...
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Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper Nrx IV during neuron glia interactions
... embryogenesis of sim-Gal4 UAS-CD8::GFP Drosophila embryos. Composite confocal images of single CNS segments in sagittal (sag; A ⬘ -D ⬙ ,E ⬘ -E ⬙⬙ ) or ventral (ven; F ⬘ -F ⬙⬙ ) views. A lower magnification overview of ...
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Glia in mammalian development and disease
... do glia prune synapses? Early insight came from work in Drosophila , where it was found that glia phagocytose degenerating axonal debris during development, in both the CNS and ...by glia is ...
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The role of glia in epilepsy, intellectual disability, and other neurodevelopmental disorders in tuberous sclerosis complex
... Oligodendrocytes are the third major type of glia cell in the central nervous system and are most directly involved in development and maintenance of the white matter of the brain [50]. Akin to Schwann cells in ...
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Dual modulation on glial cells by tetrahydroxystilbene glucoside protects against dopamine neuronal loss
... Primary neuron-glia cultures were prepared from the ven- tral midbrain tissues of the embryonic day 14 ± 0.5 days of SD rats [11]. The whole brain was aseptically removed, and the mesencephalon was dissected. ...
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Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice
... Radial progenitors are specified in the absence of Nfib The intermediate filament protein nestin is expressed from E10.5 onwards in radial progenitors within the developing cortical neuroepithelium [28], and as such, ...
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Pvr receptor tyrosine kinase signaling promotes post embryonic morphogenesis, and survival of glia and neural progenitor cells in Drosophila
... and glia (reviewed by Doe, 2008; Homem and Knoblich, ...of glia that contribute to the niche (Chell and Brand, 2010; Dumstrei et ...niche glia, subperineurial glia, creates the blood-brain ...
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Drosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of Notch
... ensheathing glia enveloping the medial and ventral neuropil ...ensheathing/wrapping glia, covering the dorsal neuropil and the proximal part of the intersegmental nerve ...ensheathing/wrapping glia ...
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Morphogenesis of neurons and glia within an epithelium
... and glia exhibit epithelial properties, including tight junctions and apical-basal polarity, and develop in a manner resembling other ...and glia can be viewed as part of an epithelium continuous with the ...
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AN ANIMAL MODEL TO ASSESS THE EFFECTS OF HYDROXYUREA EXPOSURE SUGGESTS THAT THE ADMINISTRATION OF THIS AGENT TO PREGNANT WOMEN AND YOUNG INFANTS MAY NOT BE AS SAFE AS WE THOUGHT Lucía Rodríguez-Vázquez aand Joaquín Martí a,*
... Figure 2. (A) TUNEL positive cells in the cerebellar external granular layer (white arrows) from a rat administered with hydroxyurea in the perinatal life. (B) Thin plastic section (0.5 µm) from a rat cerebellum ...
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