Beta-1 adrenergic receptor
Mapping of a functional autoimmune epitope on the beta 1 adrenergic receptor in patients with idiopathic dilated cardiomyopathy
... the beta 1 receptor of C6 rat glioma ...the receptor protein by immunoblot and bound in situ to human myocardial ...the beta 1-adrenergic ...
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Ambulatory ECG-based T-wave alternans and heart rate turbulence can predict cardiac mortality in patients with myocardial infarction with or without diabetes mellitus
... the beta-1 adrenergic receptor (b1AR) Arg389Gly polymorphism (which plays a fundamental role in the regulation of cardiovascular functions) and LVH among non-diabetic and diabetic AMI ...
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Beta adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms
... myocardial adrenergic receptors, adrenergic neurotransmitters, and beta-adrenergic receptor-effector responses in nonfailing and failing hearts taken from nonfailing organ donors, ...
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Hypoxia and glucose independently regulate the beta adrenergic receptor adenylate cyclase system in cardiac myocytes
... surface beta AR density returned toward control ...in beta AR ...of 1 microM (-)- norepinephrine (NE) increased cAMP generation from ...reoxygenation. beta AR-agonist affinity assessed by ...
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Protective effects of a glucocorticoid on downregulation of pulmonary beta 2 adrenergic receptors in vivo
... days 1-8) increased beta 1- and beta 2-receptor numbers by 70 and 69% above control, respectively, but did not change their mRNA ...decreased beta 1- and beta ...
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Impaired beta adrenergic receptor binding and function in cystic fibrosis neutrophils
... abnormal adrenergic and cholinergic physiologic responses in addition to decreased beta adrenergic-induced cyclic AMP generation in human ...assessing beta adrenergic receptor ...
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Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma
... with (±)-propranolol HCl, the β1-specific antagonist metoprolol tartrate or the β2-specific antagonist ICI 118,551 hydrochloride. While the β1-specific antagonist had no effect on viability, the β2-specific antagonist ...
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Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes
... In this review we present an updated exposition of the current knowledge in the relationship between ageing and βARs, summarizing the major findings of research on ageing in several organs expressing βARs (Table ...
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Molecular characterization of [beta]2 adrenergic receptor haplotypes
... luciferase reporter vector system. We cloned the promoter region, from subjects 66 (see Results) who were homozygous for each of the three major haplotypes, into the luciferase reporter vector pGL3-Basic. Luciferase ...
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[beta]2-adrenergic receptor modulation of macrophage inflammatory mediator production
... anti-inflammatory effects of both epinephrine and norepinephrine. Additional experiments employing isoproterenol, a β -AR agonist, mimicked the effects of epinephrine and norepinephrine upon MIP-1 α production. ...
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CHARITY: Cha gas car diomyopathy bi soprolol int ervention study: a randomized double blind placebo force titration controlled study with Bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT00323973]
... to beta-blockade could be expected to be beneficial in this situation, even in non ischemic CHF ...circulating beta-adrenergic antibodies in Cha- gas' disease providing further theoretical support ...
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Adrenergic receptor control mechanism for growth hormone secretion
... Alpha adrenergic blockade with phentolamine during insulin hypoglycemia, ...U/kg). Beta adrenergic blockade with propranolol during insulin hypoglycemia significantly enhanced HGH concentrations in ...
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Effects of Adrenergic Receptor Activation and Blockade on the Systolic Preejection Period, Heart Rate, and Arterial Pressure in Man
... prolongation accompanying pharmacologic vasoconstriction occurred after the onset of the first heart sound, thereby excluding changes in electrical-mechanical delay as a major factor in the observed preejection period ...
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Beta adrenergic receptor polymorphisms: A basis for pharmacogenetics
... Normal function of β-adrenergic receptors plays an im- portant role for cardiovascular and neurohumoral ho- meostasis in humans. Heart rate, arterial pressure, myo- cardial contractility, glucose metabolism and ...
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Impaired formation of beta adrenergic receptor nucleotide regulatory protein complexes in pseudohypoparathyroidism
... the beta-agonist isoproterenol competing with [125I]pindolol were shallow (slope factors less than 1) and were computer fit to a two-state model with corresponding high and low affinity for the ...of ...
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Science review: Mechanisms of beta receptor stimulation induced improvement of acute lung injury and pulmonary edema
... Beta-2 adrenergic agonists modulate the expression of the epithelial apical sodium channel as well as the expression of the Na,K-ATPase ...the beta blocker propranolol were added, the rate of edema ...
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Beta-adrenergic receptor stimulation limits the cellular proarrhythmic effects of chloroquine and azithromycin
... At 1 Hz pacing, therapeutic doses of chloroquine and azithromycin (5 and 20 µM, respectively) individually prolonged AP duration (APD) by 33% and ...with 1 µM isoproterenol corrected the drug-induced APD ...
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Genetic and epigenetic interactions in adaptive thermogenesis pathways in association with obesity from a Public Health Genomics perspective
... included beta-3 adrenergic receptor (adrB3), uncoupling protein 1 (ucP1), the transcription factors peroxisome proliferated activator receptor gamma (PParγ), peroxisome proliferated ...
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A single-nucleotide polymorphism of the beta 2-adrenergic receptor gene can predict pathological complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer
... in this study were participants from two open-label, pro- spective trials (SHPD001 and SHPD002). All participants from the two trials who were willing to take part in this study and provide informed consent were enrolled ...
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The Role of Beta-Adrenergic Receptor Blockers in Autism
... NOX mediates critical physiological and pathological processes including cell signaling, inflammation and mitogenesis, by generating reactive oxygen species (ROS) from molecular oxygen. Mitochondrial dysfunction and ...
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