Beta-3 adrenergic receptor
Tissue distribution of beta 3 adrenergic receptor mRNA in man
... studies. beta 3-AR transcripts were abundant in infant perirenal brown adipose tissue, characterized by the presence of uncoupling protein (UCP) ...tissues, beta 3-AR mRNA levels were high in ...
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Phosphorylation of Beta 3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes
... C57BL/6J mice were purchased from Jackson Laboratories (Jackson Labs, 000664) and fed with HFD for 8 weeks. Chronic administration: Trametinib (MEKi, 3 mg/kg) or PD0325901 (PD, 10 mg/kg) was administered by daily ...
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A paired sibling analysis of the beta 3 adrenergic receptor and obesity in Mexican Americans
... In humans, circulating leptin concentrations are highly cor- related with both body mass index and percent body fat (13, 14). We have recently localized a major quantitative trait locus (QTL) influencing serum ...
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Evidence for paternal imprinting of the Beta-3 adrenergic receptor gene and a variant association with reduced twinning rate in New Zealand merino sheep (Ovis aries L.)
... Although since the publication of Forrest (2002) the effect of non-coding variation on phenotype has been debated (Graur et al 2013) there has since been evidence for intron variation effect on phenotype. More recent ...
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Genetic and epigenetic interactions in adaptive thermogenesis pathways in association with obesity from a Public Health Genomics perspective
... cellular receptor beta-3 adrenergic receptor (ADRB3) responds to noradrenalin and mediates lipolysis in ...activated receptor gamma (PPARγ) is positively associated with the BMI ...
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Parainfluenza 3 Infection Blocks the Ability of a Beta Adrenergic Receptor Agonist to Inhibit Antigen induced Contraction of Guinea Pig Isolated Airway Smooth Muscle
... parainfluenza 3 or virus growth medium 4 d before performing in vitro pharmacological studies on tracheal and bronchial smooth ...a beta adrenergic receptor agonist, ...
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The Role of Beta-Adrenergic Receptor Blockers in Autism
... 2', 3’-cyclic nucleotide 3'-phosphodiesterase (CNPase) and MBP were reduced ...nucleotide 3'- phosphodiesterase (CNPase) activity. Receptor types expressed by HOG cells included A 2 ...
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Hypoxia and glucose independently regulate the beta adrenergic receptor adenylate cyclase system in cardiac myocytes
... reexposure to oxygen cell surface beta AR density returned toward control levels. Cells exposed to hypoxia and reoxygenation without glucose exhibited similar alterations in beta AR density. In hypoxic ...
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Molecular characterization of [beta]2 adrenergic receptor haplotypes
... Single nucleotide polymorphisms (SNPs) can impact the activity of the corresponding protein via several mechanisms that are dependent on the position of the SNP along the gene locus. SNPs in the putative promoter region ...
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EFFECT OF GLY 16 ARG SINGLE NUCLEOTIDE POLYMORPHISM ON AGONIST BINDING TO BETA 2 ADRENERGIC RECEPTOR – A STRUCTURAL PHARMACOGENOMIC APPROACH
... Desolvation energy is a prime parameter that decides a molecules interaction with its pharmacodynamic target. In the biological environment, all drug binding pockets of a target protein remain solvated and hence a ligand ...
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Adrenergic receptor control mechanism for growth hormone secretion
... Alpha adrenergic blockade with phentolamine during insulin hypoglycemia, ...U/kg). Beta adrenergic blockade with propranolol during insulin hypoglycemia significantly enhanced HGH concentrations in ...
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CHARITY: Cha gas car diomyopathy bi soprolol int ervention study: a randomized double blind placebo force titration controlled study with Bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT00323973]
... to beta-blockade could be expected to be beneficial in this situation, even in non ischemic CHF ...circulating beta-adrenergic antibodies in Cha- gas' disease providing further theoretical support ...
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[beta]2-adrenergic receptor modulation of macrophage inflammatory mediator production
... transcriptional regulation of several pro-inflammatory molecules, the mechanisms surrounding TNF-α production are the most studied. In 2000, Farmer and Pugin published a landmark paper describing the molecular basis of ...
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Effect of dietary supplementation with Spirulina on the expressions of AANAT, ADRB3, BTG2 and FASN genes in the subcutaneous adipose and Longissimus dorsi muscle tissues of purebred and crossbred Australian sheep
... (AANAT), Adrenergic beta-3 receptor (ADRB3), B-cell translocation gene 2 (BTG2) and Fatty acid synthase (FASN) genes, which are associated with lipid ...
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Myocardial beta adrenergic receptor function during the development of pacing induced heart failure
... and 3-4 wk (n = ...after 3-4 wk of ...after 3-4 wk of pacing. Both the fraction of beta-adrenergic receptors binding agonist with high affinity and adenylyl cyclase activity decreased ...
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Beta-adrenergic receptor stimulation limits the cellular proarrhythmic effects of chloroquine and azithromycin
... to the previously observed APD reduction in the model, as previously documented (26) and preventing such phosphorylation resulted in repolarization failure (RF) in the CQ+AZM group in the presence of simulated ...
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A single-nucleotide polymorphism of the beta 2-adrenergic receptor gene can predict pathological complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer
... Thirty-six out of 130 (27.7%) patients had pCR following neoadjuvant chemotherapy. The pCR rate was 18.2% in patients with the ADRB2 rs1042713 AA genotype, 38.6% and 38.9% in patients with the AG and GG genotypes, ...
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Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma
... Despite the discrepancy between in vitro and in vivo concentrations the doses effective against NB SK- N-AS xenografts were similar to those used in regimens for hypertension and those reported for children with ...
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Diabetes and beta adrenergic blockage are risk factors for metastatic prostate cancer
... Also, beta-adrenergic signaling has been associated with advanced prostate cancer [25] and beta-blockers have been associated reduced mortality in various tumor types ...beta2 receptor ...
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Beta adrenergic receptor blockade of feline myocardium Cardiac mechanics, energetics, and beta adrenoceptor regulation
... during beta-adrenergic stimulation under fixed mechanical ...that beta-blockade may reduce oxygen consumption through effects independent of its influence on mechanical conditions and contractile ...
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