Beta cell
The triumvirate of beta cell regeneration: solutions and bottlenecks to curing diabetes
... major beta-cell specific interventions that might accomplish the goal of euglycemia maintenance without exogenous insulin ...ate beta-cell mass, the gold standard in maintaining blood glucose ...
13
Signals from the neural crest regulate beta cell mass in the pancreas
... insulin-expressing beta-cells increased in the Phox2b –/– ...the beta-cell population, and thereby impacts insulin-secretory capacity and energy ...
10
Roles of insulin resistance and beta cell dysfunction in dexamethasone induced diabetes
... and beta-cell dysfunction in glucocorticoid-induced diabetes were determined in Wistar and Zucker (fa/fa) ...increased beta-cell mass and basal and arginine- stimulated insulin secretion, ...
9
Regulators of Mouse and Human Beta Cell Proliferation
... increased beta cell proliferation during ...in beta cells compared to other islet cell types, and is efficiently deleted in sorted Cish loxP/loxP ; Pdx1-Cre Early ; MIP-GFP islet beta ...
205
American ginseng modulates pancreatic beta cell activities
... improves beta cell insulin production The inability to produce adequate amounts of insulin is a factor attributed to beta cell ...in beta cells preventing the production of insulin and ...
5
Increasing beta cell mass to treat diabetes mellitus
... insulin-secreting beta cells is evident in ...rodent beta cells. The augmentation of beta cell proliferation is supposed to reverse ...human beta cells pose difficulty in promoting the ...
7
In vivo inhibition of glucagon secretion by paracrine beta cell activity in man
... and beta cells makes possible their interaction at a local (paracrine) ...after beta cell suppression by infusions of ...in beta cell suppression, as shown by a diminution in the ...
6
Effect of protein glycation by methylglyoxal on pancreatic beta cell function
... on beta cells and involvement in early stage dysfunction and development of type 2 diabetes mellitus are not ...on beta cell function and related involvement in the development of ...of beta ...
232
Sorting Ourselves Out: Seeking Consensus on Trafficking in the Beta Cell
... of cell types) is the presence by electron microscopy of an electron-dense core in the secretory granule ...pancreatic beta-cells that proinsulin (not its conversion products insu- lin and C-peptide) is ...
9
Stem cell approaches for diabetes: towards beta cell replacement
... Mesenchymal stromal cells and hematopoietic stem cells Mesenchymal stromal cells (MSCs), also known as mesen chymal stem cells, have attracted a great deal of interest because of their potential to enhance regenera- tion ...
9
Cell therapies for pancreatic beta-cell replenishment
... pancreatic beta-cells would represent an ideal treatment that could overcome the above mentioned therapeutic ...of cell-substitutes to replenish the beta cell population, has blurred the hype ...
9
Effect of age on glucose stimulated insulin release by the beta cell of the rat
... of beta-cells and the volume of beta-granules per ...that beta-cell number increased from 2,300 t0 5,000 cells as rats aged from 2 to 18 mo and islet insulin content ...of ...
10
Transplanted beta cell response to increased metabolic demand Changes in beta cell replication and mass
... transplanted beta cells to modify their replication and mass when stimulated by changes in metabolic ...transplanted beta cells increased in Tx-Px ...pancreatic beta cells (0.38 +/- 0.05%) (P < ...
7
glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
... of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic ...of cell fate acquisition and ...insulin-secreting beta cells following targeted ...
11
Taurine regulates insulin release from pancreatic beta cell lines
... We demonstrate here that taurine transport into pan- creatic b -cells may initiate the calcium-dependent release of insulin and GABA, independent of extracellu- lar glucose concentrations. Experimentally, glucose con- ...
8
Glucose sensing in the pancreatic beta cell: a computational systems analysis
... a cell-permeant compound that was reported to inhibit UCP2-mediated proton leak, increased the mitochondrial membrane potential and cytosolic ATP, closed K ATP channels, and stimulated insulin secretion ...
44
Non-Immune Islet beta cell susceptibility to failure in NODk mice
... relatively inactive and has to be processed into proinsulin in order to eventually make the insulin hormone. Pre-proinsulin contains a hydrophobic N-terminal signal peptide, which interacts with cytosolic ...
226
Unraveling The Beta Cell Translatome: Elucidation Of An Erk/hnrnpk/jund Axis
... β cell dysfunction, leading us to identify a cohort of translationally regulated genes with 3’UTR enrichment of a cytosine-rich ...other cell types but whose role in cells is ...β cell dysfunction, ...
181
Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
... Insulin (Architect Abbott, 2000I) and C-peptide (Immu- lite 2000, Siemens) were determined with chemilumines- cent immunometric assays. Intact proinsulin was assessed through ELISA (Millipore, Billerica, MA, USA). This ...
10
Pancreatic Beta Cell Plasticity and Involvement of Insulin- Expressing Progenitor Cells
... coincides with the developmental shift to larger islets and fewer β-cell aggregates as demonstrated here. We propose that in addition to the hormonal demands and somatic growth necessary at this age (26), ...
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