BETULINIC ACID
Synthesis, Characterization and Cytotoxic Activity of Betulinic Acid and Seco-Betulinic Acid Derivatives against Human Colorectal Carcinoma
... To a solution of betulinic acid 1 (30.0 mg, 0.07 mmol) in dry THF (2 mL) was added HOBt (11.2 mg, 1.1 equiv.), HBTU (30.0 mg, 1.0 equiv.) at 0°C and trimethylsiloxycyclohexene amine TFA salt 3 or ...
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Human Immunodeficiency Virus Type 1 Resistance to the Small Molecule Maturation Inhibitor 3-O-(3′,3′-Dimethylsuccinyl)-Betulinic Acid Is Conferred by a Variety of Single Amino Acid Substitutions at the CA-SP1 Cleavage Site in Gag
... controls demonstrated that the binding had reached equilibrium under these conditions and that the binding could be competed by unlabeled DSB but not by the inactive compound betulinic acid (J. Zhou and C. ...
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DDB and Betulinic Acid-Derivatives as Potent Chemosensitizing, Chemopreventive, and Anti-HIV Agents
... Bevirimat (BVM), also known as PA-457, DSB, and MPC-4326, is 3-O-(3,3- dimethylsuccinyl)betulinic acid, a derivative of BA. Bevirimat, now in clinical phase II trials, is the first member of the novel ...
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Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay
... by betulinic acid in scramble-transfected nci-h716 cells, marked as Tgr5 (+) cells, compared with cells that received sirna targeting Tgr5, marked as Tgr5 (−) cells, are shown in ...lithocholic acid ...
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Design, synthesis, and biological evaluation of betulinic acid derivatives as potent anti-HIV-1 agents
... unless otherwise indicated. Mass spectra were measured on Shimadzu LCMS-2010 (ESI-MS). Optical rotations were measured with a Jasco Dip-2000 digital polarimeter at 20 °C at the sodium D line. Thin-layer chromatography ...
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Selective extraction of betulinic acid from Zizyphus joazeiro Mart bark: A preliminary study
... Zizyphus joazeiro Mart. (Rhamnaceae), which is a tree that grows in northeastern Brazil, is widely used in traditional Brazilian medicine for the treatment of fever, mycosis, chronic bronchitis and gastric ulcers [1, 2]. ...
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ESTIMATION OF BETULINIC ACID IN EXTRACTS AND FORMULATIONS CONTAINING ALBIZIA LEBBECK BY HPLC
... using betulinic acid as a marker compound and validated as per ICH ...of betulinic acid in three ethyl acetate extracts and marketed herbal formulations containing Albizia ...
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DEVELOPMENT AND VALIDATION OF RP HPLC METHOD FOR QUANTIFICATION OF BETULINIC ACID IN VITEX NEGUNDO L AND ITS POLYHERBAL FORMULATIONS
... The leaves of Vitex negundo collected from the L. M. College of Pharmacy, Ahmedabad, Gujarat. Reference standard of Betulinic acid (HPLC purity >98.0 %) was purchased from Sigma aldrich, Bangalore, ...
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Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid
... dermal fibroblast cells using oxidized MWCNTs at three concentrations (40, 200, and 400 µ g/mL). Their findings suggested that an amount 40 µ g/mL of oxidized MWCNTs could be utilized for a CNT drug delivery system in ...
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Betulinic Acid-induced Mcl-1 Expression in Human Melanoma — Mode of Action and Functional Significance
... to betulinic acid (7), as mitochondrial apoptosis inducing ...to betulinic acid. It is conceivable that betulinic acid may induce cell death through another - still unidentified - ...
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The inhibition of assembly of HIV 1 virus like particles by 3 O (3',3' dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc binding domain
... 3-O-(3',3'-dimethylsuccinyl)-betulinic acid (or YK- FH312 [1], or PA-457 [2], or Bevirimat™ [3,4]), has been used as an antiviral which blocks HIV-1 replication via its inhibitory activity on Gag ...
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Variation of Ursolic and Betulinic Acid in Five Malus × domestica clones from Southern Brazil
... ursolic acid (UA) and betulinic acid (BA) in apple peel extract of five clones of Gala and Fuji cultivars (“Baigent”, “Fuji Mishima”, “Fuji Suprema”, “Fuji Select” and “Maxi Gala”) from southern ...
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QUANTIFICATION OF OLEANOLIC ACID AND BETULINIC ACID BY TLC AND BRINE SHRIMP LETHALITY ASSAY OF NYMPHAEA STELLATA WILLD. LEAVES
... Pure oleanolic acid and betulinic acid were procured from Himedia Laboratories Pvt. Ltd., Mumbai, India. Brine shrimp eggs were purchased from Ocean Star International Inc., Snowville, UT, USA. Other ...
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Protective potential of betulinic acid against glyphosate induced toxicity in testis and epididymis of male wistar rats
... has been confirmed through co-administration of BA with catalase. The down regulation of the Spproteins was reversed by the catalase, which mopped up hydrogen peroxide (Chintharlapalli et al., 2011). It has been ...
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Biological Activity of Betulinic Acid: A Review
... Betulinic acid, (3β-hydroxy-lup-20(29)-en-28-oic acid) (Figure 1) is a naturally occurring pentacyclic lupane- type triterpenoid which exhibits a variety of biological and medicinal properties such ...
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A simple preparation of betulinic acid from sycamore bark
... Betulinic acid has several botanical sources, but can also be chemically derived from betulin [1–3], a substance found in abundance in the outer bark of white birch ...trees. Betulinic acid ...
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Betulinic Acid Glycosides: A Review
... the medical applications of betulinic acid in the pharmaceutical industry have been strongly limited since it is insoluble in water (0.02 mg/ml) as well as in organic solvents, causing a difficulty in ...
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Induction of apoptosis by a potent Betulinic acid derivative in Human colon carcinoma HT-29 cells
... production and caspases activation. Moreover, HT-29 cells treated with BC-SM-05 and stained with Hoechst 33258 showed formation of apoptotic bodies and DNA degradation whereas untreated cells had intact nuclei. All ...
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Solubility of Betulinic Acid in Microemulsion System: (Part 2)
... of betulinic acid dissolved was at ...acetic acid. It was observed that the weights of betulinic acid dissolved were inversely proportional to the water ...
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Original Article Improvement of management of cervical cancer through betulinic acid-poly (ethylene glycol) - thiolgold nanoparticle conjugates
... of betulinic acid followed by thio- acetate protection and deprotection was used for the development of nanoparticle ...chloroauric acid to turkevich ...
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