Binding and entry
Cellular receptor binding and entry of human papillomavirus
... cellular entry for many viruses. The binding of ligand to a specific receptor is widely recognized to result in the clustering of the ligand-receptor complexes in the coated pits on the plasma membrane ...
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The Evolving Field of Human Papillomavirus Receptor Research: a Review of Binding and Entry
... the entry of HPVs has remained ...simple binding and uptake through a singular mechanism has given way to a model of a more complex interaction between several specific receptors, coreceptors, and cofactors ...
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Binding of more than one Tva800 molecule is required for ASLV A entry
... viral binding and entry; however, previous studies have tended to concen- trate on the stoichiometry of viral envelope binding in relation to entry ...viral binding and ...that ...
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6-O- and N-Sulfated Syndecan-1 Promotes Baculovirus Binding and Entry into Mammalian Cells
... baculovirus binding, and SDC-1 overexpression enhanced baculovirus-mediated ...the binding and entry of baculovirus in vertebrate ...baculovirus entry and can serve as a basis for ...
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Role of the Asialoglycoprotein Receptor in Binding and Entry of Hepatitis C Virus Structural Proteins in Cultured Human Hepatocytes
... The precise mechanisms of early steps of HCV infection remain largely unknown. Attempts to elucidate those mecha- nisms have been hampered by the difficulties to obtain a suf- ficient amount of free virion from the ...
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Interaction of Hepatitis C Virus-Like Particles and Cells: a Model System for Studying Viral Binding and Entry
... The internalization of labeled-HCV-LPs is shown to be specific for HuH7 and NKNT-3 cells and also HepG2 (data not shown). Although we could not be absolutely sure that the incorporated dye inside the cell represents ...
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Opposing Effects of Bacitracin on Human Papillomavirus Type 16 Infection: Enhancement of Binding and Entry and Inhibition of Endosomal Penetration
... cell binding and continuous cellular uptake of HPV16 through an infectious ...increased binding and uptake, the fact that it occurs during the 4°C binding step indicates that the phenomenon likely ...
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Importance of Vp1 Calcium-Binding Residues in Assembly, Cell Entry, and Nuclear Entry of Simian Virus 40
... In summary, we have shown that certain acidic side chains from the two structurally deduced calcium-binding sites con- tribute to the formation of infectious SV40. The potential to chelate calcium ions at both ...
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Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: Putative CD81 binding region 1 is not involved in CD81 binding
... and are thus obviously a relevant cell lines for this analy- sis, confirmatory screening was also performed in Hep3B cells, which have been shown to be permissive for HCVpp entry. Infectivity was determined as a ...
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MiniCD4 protein resistance mutations affect binding to the HIV 1 gp120 CD4 binding site and decrease entry efficiency
... Background: Binding of the viral envelope protein (Env), and particularly of its gp120 subunit, to the cellular CD4 receptor is the first essential step of the HIV-1 entry ...CD4 binding site (CD4bs) ...
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Binding of Adenovirus Capsid to Dipalmitoyl Phosphatidylcholine Provides a Novel Pathway for Virus Entry
... choline. Clearly, new experiments are required to identify the hexon domain(s) involved in phospholipid binding. Ad is a very efficient respiratory pathogen. However, a low concentration of primary and secondary ...
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A Point Mutation in the Binding Subunit of a Retroviral Envelope Protein Arrests Virus Entry at Hemifusion
... during entry of enveloped ...receptor binding subunit of a murine leukemia virus (MLV) envelope protein block infection and induction of cell-cell fusion but not receptor ...
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The Human Metapneumovirus Fusion Protein Mediates Entry via an Interaction with RGD-Binding Integrins
... integrin binding is medi- ated largely by the RGD motif and that HMPV F-integrin engage- ment is essential for receptor-binding ...virus binding; there are likely other residues in both proteins that ...
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Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation
... the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABp was investigated using NMR spectroscopy and biophysical ...overall binding affinity and the association ...
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Surfactant Protein A Binding to Cytomegalovirus Proteins Enhances Virus Entry into Rat Lung Cells
... CMV binding to and infection of various types of lung cells, es- pecially type II cells and ...virus entry, SP-A may contribute to the pathogenesis of CMV infec- tion in the ...
Cell entry by measles virus: long hybrid receptors uncouple binding from membrane fusion.
... cell entry of other viruses. Transferring the HIV binding site nearer to the cell membrane resulted in loss of fusion (35); however, this study was designed to define the CD4 domains which play a role in ...
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Decay-Accelerating Factor Binding Determines the Entry Route of Echovirus 11 in Polarized Epithelial Cells
... occurs. Binding of EV11-207 to DAF and its transport to tight junctions result in a loss of function of the ...DAF binding appears be a key determinant in the choice of entry pathway, at least in ...
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Coupling of receptor interference and a host dependent post binding entry deficiency in a gammaretroviral envelope protein
... viral binding and is probably less important than the interaction between the VRA and Xpr1 for viral ...simple binding to a receptor protein is not sufficient for a successful fusion event, but the ...
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Hepatitis C Virus Envelope Glycoprotein E2 Glycans Modulate Entry, CD81 Binding, and Neutralization
... CD81 binding site, rendering it more accessible to CD81 as well as neutralizing ...the binding of soluble E2 and virions to target cells, suggesting that this region regulates E2-receptor interactions (48, ...
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Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase
... PCNA binding domain and an intact cyclin-dependent kin- ase binding domain whereas CDKN1C BWS-mutant pro- tein contains a mutation in the cyclin-dependent kinase binding domain and a wild-type PCNA ...
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