Biochemical Recurrence
Positive surgical margin is associated with biochemical recurrence risk following radical prostatectomy: a meta analysis from high quality retrospective cohort studies
... Prostate cancer (PCa) is the most diagnosed malignancy and the second leading cause of cancer-related deaths among men in Western countries [1]. Radical prostatectomy (RP) has been shown to have a cancer-specific ...
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A single nucleotide polymorphism in ADIPOQ predicts biochemical recurrence after radical prostatectomy in localized prostate cancer
... Adiponectin has been implicated in prostate cancer (PCa) aggressiveness. However, the role of genetic variations in the adiponectin (ADIPOQ) gene in PCa progression remains unknown. To determine whether genetic variants ...
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Examining the association between adiposity and biochemical recurrence after radical prostatectomy
... Additionally, the median follow-up is intermediate at 5.9 years, limiting the ability to conclude definitively whether SP or OS are impacted by adiposity. Finally, this study only measured adiposity at a single point in ...
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Targeted salvage lymphadenectomy in patients treated with radical prostatectomy with biochemical recurrence: complete biochemical response without adjuvant therapy in patients with low volume lymph node recurrence over a long-term follow-up
... Biochemical recurrence following surgical treatment of prostate cancer is a common ...with biochemical recurrence and nodal recurrence after a radical prostatectomy ...with ...
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Association of PTEN expression with biochemical recurrence in prostate cancer: results based on previous reports
... Purpose: Among men, prostate cancer (PCa) is one of the most commonly diagnosed cancers and the leading cause of cancer death worldwide. Phosphatase and tension homolog (PTEN) acts as a negative regulator of the ...
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Body mass index is associated with higher Gleason score and biochemical recurrence risk following radical prostatectomy in Chinese men: a retrospective cohort study and meta analysis
... Background: The aim of the study is to investigate whether body mass index (BMI) affected pathological characteristics and biochemical recurrence (BCR) of prostate cancer after radical prostatectomy in ...
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Evaluation of biochemical recurrence in patients with high-risk prostate cancer treated with radical prostatectomy and radiotherapy plus androgen deprivation therapy
... Keywords: high-risk prostate cancer, radical prostatectomy, radiotherapy plus androgen depri- vation therapy, biochemical recurrence, number of risk factors.. Introduction.[r] ...
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Does whole-body bone SPECT/CT provide additional diagnostic information over [18F]-FCH PET/CT for the detection of bone metastases in the setting of prostate cancer biochemical recurrence?
... However, biochemical recurrence (BR) occurs in 20– 50% of patients within 10 years following local treatment ...chemical recurrence, determining whether the disease is locally confined or ...
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Predictors of time to biochemical recurrence in a radical prostatectomy cohort within the PSA era
... In this study, we sought to understand the clinical factors associated with early or late biochemical recurrence among a cohort of localized PCa patients who underwent RP. Our results show that there are ...
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Level of invasion into fibromuscular band is an independent factor for positive surgical margin and biochemical recurrence in men with organ confined prostate cancer
... All oncologic surgeries aim to completely remove cancers. Therefore, the presence of a positive surgical margin (PSM) after radical prostatectomy (RP) for pros- tate cancer is considered an adverse event in curing this ...
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Management algorithms for prostate specific antigen progression in prostate cancer: Biochemical recurrence after definitive therapy and progression to non metastatic castrate resistant prostate cancer
... As existing guidelines were current to March 2018 (NCCN 2018 v2; data cut-off February 2018), 4 a supplementary search for new data was performed. PubMed and ASCO GU were searched for reports of original phase III trials ...
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High-risk prostate cancer: factors predicting biochemical recurrence after radical prostatectomy
... Methods. Data on high-risk prostate cancer patients between 2005 and 2009 were retrospectively reviewed in two cancer centers: Nation- al Cancer Institute, Vilnius, Lithuania, and N. N. Alexandrov National Cancer Centre ...
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Decreased expression of SLC39A14 is associated with tumor aggressiveness and biochemical recurrence of human prostate cancer
... Results: The immunoreactive scores of SLC39A14 protein in human PCa tissues were sig- nificantly lower than those in normal prostate tissues. Based on the Taylor dataset, SLC39A14 downregulation occurred more frequently ...
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Preoperative PROSTATE scoring system: a potential predictive tool for the risk of biochemical recurrence after radical prostatectomy
... BCR, biochemical recurrence; RP, radical prostatectomy; PCa, prostate cancer; ROC curve, receiver operating charac- teristic curve; PSM, positive surgical margin; PSA, prostate specifi[r] ...
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Risk factors for biochemical recurrence after robotic assisted radical prostatectomy: a single surgeon experience
... Shikanov et al. reported not only the presence of PSM but also PSM length (> 3 mm) to be independently asso- ciated with BCR. Interestingly, patients with negative margins and those with a positive margin less than 1 ...
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Combined overexpression of HIVEP3 and SOX9 predicts unfavorable biochemical recurrence- free survival in patients with prostate cancer
... Methods: A small interfering RNA was used to knockdown SOX9 expression in a PCa cell line and to analyze the effects of SOX9 inhibition on the expression of HIVEP3 in vitro. Then, HIVEP3 and SOX9 expression patterns in ...
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Cancer/Testis antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy
... without recurrence and 43 patients with ...experienced biochemical recurrence within a median of 1 year follow-up (range, 1 to 8 years), indicating that this cohort was a very high risk ...without ...
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UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy
... Despite the combination of increasingly refined sur- gical techniques and a reduced incidence of surgical complications, the variable disease course in PCa eventually leads to recurrence in about one-third of ...
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Impact of Ga-68-PSMA PET/CT on management in prostate cancer patients with very early biochemical recurrence after radical prostatectomy.
... post-prostatectomy biochemical relapse (BCR) remains a significant problem, with 20% to 30% patients experiencing prostate-specific anti- gen (PSA) failure following radical prostatectomy ...2.6% ...
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Perineural invasion as an independent predictor of biochemical recurrence in prostate cancer following radical prostatectomy or radiotherapy: a systematic review and meta-analysis
... According to the PRISMA guidelines [9], a systematic literature search of the PubMed, EMBASE, Chinese Na- tional Knowledge Infrastructure (CNKI) and Wan Fang databases was performed (up to May 2017). The search strategy ...
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