Bispecific antibodies
The development of bispecific antibodies and their applications in tumor immune escape
... combine bispecific antibodies to generate T cells that could recognize multiple ...first bispecific CAR T cells, which could simultaneously recognize both of CD19 and CD20, were developed to prevent ...
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Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization
... tralizing antibodies has been isolated and ...vary. Antibodies to the CD4bs and the MPER are the most broadly reactive, neutralizing 90% to 98% of viruses, but often are not as potent as bNAbs to the ...
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Use of Bispecific Antibodies in Molecular Velcro Assays Whose Specificity Approaches the Theoretical Limit of Immunodetection for Bordetella pertussis
... before the fusion. After PEG fusion, cells with double fluores- cence could be sorted and plated at one cell per well. Gener- ally, the efficiency of quadroma production is low. In our ex- perience with numerous fusions ...
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Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia
... TKIs, bispecific antibodies, antibody-drug conjugates, and CAR T cells are changing the treatment paradigm for ALL. More targeted agents including BTK inhibitors (ibrutinib, acalabrutinib), BCL-2 inhibitor ...
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TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies
... monoclonal antibodies with exquisite specificity for the LMP2A-derived nonamer peptide, C 426 LGGLLTMV 434 (CLG), as presented on ...engaging bispecific antibodies (DiBsAb) of clone 38 and an ...
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Development and clinical application of anti-HER2 monoclonal and bispecific antibodies for cancer treatment
... monoclonal antibodies (e.g. trastuzumab, pertuzumab), bispecific antibod- ies ...anti-HER2 bispecific antibody ...HER2-directed bispecific antibody may be a promising therapeutic approach for ...
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Efficient and Highly Specific Gene Transfer Using Mutated Lentiviral Vectors Redirected with Bispecific Antibodies
... challenges, including relatively modest transduction efficiency, lack of stable transgene integration, natural tropism to liver for off-target effects, and the need to use a very high MOI to achieve necessary ...
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Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies.
... The relative transduction efficiencies of primary HISMC and primary HuVEC were compared with the transduction efficiency of A549 alveolar carcinoma cells by using a recombinant adenoviru[r] ...
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Bispecific antibodies and their applications
... peutic antibodies have become a mainstay of therapeutic options for patients with cancer and autoimmune, in- flammatory, and various other diseases [2, ...sufficiently. Bispecific anti- bodies (BsAbs) have ...
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Bispecific antibodies: design, therapy, perspectives
... Abstract: Antibodies (Abs) containing two different antigen-binding sites in one molecule are called ...bispecific. Bispecific Abs (BsAbs) were first described in the 1960s, the first monoclonal ...
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Recent advances of bispecific antibodies in solid tumors
... antidrug antibodies were detected in 19 ...anti-PD-L1 antibodies could significantly enhanced T cell cytotoxicity activity ...T-cell bispecific (TCB) ...cell bispecific antibody that harbors ...
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Bi-specific and tri-specific antibodies- the next big thing in solid tumor therapeutics
... specific antibodies to distribute to the tumor antigen site followed by the administration of a small radioactive agent with high affinity for the tumor antibody, limits the accumulation of radiation in non-target ...
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Engineering multi specific antibodies against HIV 1
... potent bispecific antibodies against HIV-1 identified to ...scFv bispecific format ...scFv bispecific antibody discussed earlier, it is possible that the PG9 moiety may not be positioned at ...
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Rapid Detection of Hepatitis B Virus Surface Antigen by an Agglutination Assay Mediated by a Bispecific Diabody against Both Human Erythrocytes and Hepatitis B Virus Surface Antigen
... and bispecific antibodies have many potential appli- cations, including immunodiagnosis and immunotherapy of can- cer, autoimmune diseases, and infectious ...allow antibodies to bind to antigens with ...
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Efficient and Selective Gene Transfer into Primary Human Brain Tumors by Using Single-Chain Antibody-Targeted Adenoviral Vectors with Native Tropism Abolished
... A prime objective in the development of AdV for gene therapy is cell type-specific targeting through vector tropism modification. Targeting may augment gene delivery to tissues of interest that do not express sufficient ...
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Synergistic Neutralization of Pertussis Toxin by a Bispecific Antibody In Vitro and In Vivo
... distinct bispecific architectures have been reported, ranging from constructs with a near-native immunoglobulin structure to various single-chain variable-fragment (scFv) fusions ...hu11E6 antibodies, ...
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Targeted cancer immunotherapy via combination of designer bispecific antibody and novel gene engineered T cells
... tiple antibodies against tumor associated antigens (TAAs) have been identified and exploited against different types of cancers though their mode of activity is largely inde- pendent of T-cell ...by ...
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Construction, expression and binding specificity of bispecific CD3 × VEGFR 2 and CD3 × NCAM antibodies in the single chain and diabody format
... Bispecific antibodies are recombinant proteins with novel immunological properties and therapeutic po- ...several bispecific antibodies comprising different va- riable domain combinations with ...
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PROTEINS AND PEPTIDES AS TARGETING CARRIERS IN ANTICANCER DRUG DELIVERY: A REVIEW
... monoclonal antibodies (MAbs), bispecific antibodies (BsAbs), Affibody molecules, albumin, transferrin and peptides such as stable microbial toxins and cell penetrating peptides (CPPs) as innovative ...
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A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy
... In the field of immune cell therapy, the bispecific antibodies can be developed as an efficacious bridge to recruit the cytotoxic T cells to kill cancer cells while simultaneously target[r] ...
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