BMP-7
Osteochondral tissue engineering using a biphasic collagen/GAG scaffold containing rhFGF18 or BMP-7 in an ovine model
... The BMP-7 group showed the worst results of all in the LTS with a wide variability ...the BMP-7 treated group, poor defect fill was seen in four of the six LTS defects with very poor Safranin ...
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Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) regulate supernumerary organ formations
... of BMP-7 deficient mouse, specific phenotypic alterations are ...with BMP as well as other signaling pathways ...derived BMP signals for the further development of the dental ...the BMP ...
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Original Article BMP-7 attenuates liver fibrosis via regulation of epidermal growth factor receptor
... whether BMP-7 has an effect on HSC activation, and cells were pretreated with or without different concentrations (500, 1000, 2000 ng/ml) BMP-7 (Peprotech, 120-03) 30 min before the treatment ...
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Chlorogenic acid attenuates kidney fibrosis via antifibrotic action of BMP 7 and HGF
... Background: Kidney fibrosis, characterised by tubulointerstitial fibrosis, is a histological landmark of chronic kidney disease. The body attempts to compensate for progressive detrimental process of kidney fibrosis by ...
5
Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis
... increased BMP-7 mRNA level was seen after stimula- tion with telmisartan alone, revealing an AT-II inde- pendent effect of telmisartan on BMP-7 ...
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Auricular cartilage repair using cryogel scaffolds loaded with BMP-7-expressing primary chondrocytes
... of BMP-7 in bone and cartilage regeneration (Bessa et al., 2008). BMP-7 activates cartilage matrix synthesis and has a role in chondrogenesis, however, it also activates bone formation and ...
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rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP 7/Smad1/5/8 pathway
... Background: Activation of hepatic stellate cells is the dominant pathogenic event during the process of liver fibrosis. Bone morphogenic protein (BMP)-7 has recently been identified as an anti-fibrotic ...
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Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7
... the BMP-7 derived short functional peptide, DIF-7c, can maintain bioactivity for a longer period in comparison with the large BMP-7 ...
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Simultaneous gene transfer of bone morphogenetic protein (BMP) 2 and BMP 7 by in vivo electroporation induces rapid bone formation and BMP 4 expression
... pCAGGS- BMP-7, pCAGGS-BMP-2 and pCAGGS-BMP-7, or pCAGGS alone were killed under general anesthesia and the target muscles were resected ...5, 7, and 9 days after gene ...human ...
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Bone Morphogenetic Protein (BMP)-4 and BMP-7 regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF)
... Normal human lung fibroblast culture and stimulation Primary adult human lung fibroblasts obtained from healthy, non-smoking donors, (NHLF, Lonza Rockland Inc, Rockland, ME, USA) were seeded in 12-well plastic culture ...
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The treatment of nonunions with application of BMP-7 increases the expression pattern for angiogenic and inflammable cytokines: a matched pair analysis
... of BMP-7 contributes to improved bone regeneration in nonunion therapy by modulation of the angiogenic and inflammable cytokine expression patterns of the early inflammation ...of BMP-7 (G2, ...
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Phase 1 safety and tolerability study of BMP 7 in symptomatic knee osteoarthritis
... The imaging assessments conducted as part of this study provided no suggestion of either an adverse safety profile or hints of efficacy. We do know (via unpub- lished preclinical data) that there is the potential for ...
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<p>Exfoliated Human Deciduous Tooth Stem Cells Incorporating Carbonate Apatite Scaffold Enhance BMP-2, BMP-7 and Attenuate MMP-8 Expression During Initial Alveolar Bone Remodeling in Wistar Rats (<em>Rattus norvegicus</em>)</p>
... ple, BMP-2 and BMP-7 can enhance osteogenic bone ...induce BMP-2 and BMP-7 expression to sti- mulate bone ...the BMP-2 expression level that stimu- lates in vivo ...
7
Transforming growth factor β1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?
... (SARA), BMP and activin receptor membrane bound inhibitor (BAMBI), v-ski sarcoma viral oncogene homolog (Ski), Ski-related novel protein N (SnoN), sclerostin and ...with BMP for receptor binding ...
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Original Article Bone morphogenetic protein 7 alleviates paraquat-induced pulmonary fibrosis via TGF-β1/Erk1/2 pathway
... of BMP-7 on PQ-induced fi- brotic injury, MRC-5 cells were treated with PQ ...of BMP-7 (20 µg/mL). BMP-7 signifi- cantly reduced PQ-induced apoptotic rate and collagen I ...
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Association between expression of the Bone morphogenetic proteins 2 and 7 in the repair of circumscribed cartilage lesions with clinical outcome
... But BMP-2 was the only intraarticular cytokine which correlated with the degree of clinical improve- ment measured by the IKDC ...that BMP-2 plays a significant role in cartilage repair and ...showing ...
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Non-unions treated with bone morphogenic protein 7: introducing the quantitative measurement of human serum cytokine levels as promising tool in evaluation of adjunct non-union therapy
... of BMP and BFGF contradictory conclusions have been found, in particular studies have shown stimulatory and inhibitory effects ...factor. BMP-7 application led to an enormous increase in bFGF expres- ...
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A living thick nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration
... of BMP-7 and followed bone regeneration in vitro and in vivo in ...of BMP-7 (NR4) (Figure ...of BMP-7, has been previously proved in experiments involving nanoreservoirs of ...
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Association of ex-vivo expanded human mesenchymal stem cells and rhBMP-7 is highly effective in treating critical femoral defect in rats
... human BMP-7 (rhBMP-7), has been proved efficacious in improving bone healing in orthotopic animal models and in clinical study for the treatment of nonunion of tibial fractures ...
6
Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
... cells; BMP-7: Bone morphogenetic protein-7; CKD: Chronic kidney disease; DCs: Dendritic cells; ECFC: Endothelial colony forming cells; ECs: Endothelial cells; EMT: Epithelial – mesenchymal ...
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