bone morphogenetic protein receptor
Bone Morphogenetic Protein Receptor in the Osteogenic Differentiation of Rat Bone Marrow Stromal Cells
... of bone marrow stromal cells (BMSCs). Bone morphogenetic protein (BMP) signaling has important effects on the process of ...of bone morphogenetic protein receptor ...
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Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip
... the interactions between Notch and BMP signaling. An intriguing complement to the above is suggested by a recent report that Smad1 contains inhibitory phosphor- ylation sites that are targeted by the mitogen-activated ...
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Genetic analyses in a cohort of 191 pulmonary arterial hypertension patients
... encodes bone morphogenetic protein receptor type II, which belongs to the transforming growth factor-β (TGF-β) superfamily and is involved in the regulation of cell growth and apop- ...
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Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
... ing bone morphogenetic protein receptor II (BMPRII) [2], activin receptor-like kinase-1 (ALK-1) [3] and recent discovery of dysregulated genes encoding for hypoxia inducible factor ...
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Epidemiology and risk factors in CKD patients with pulmonary hypertension: a retrospective study
... To be mentioned, some factors were not independent de- terminants of PH in the present study, however, they might be considered a “warning”. CKD is a progressive disease and involves alterations of etiologies, eg ...
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Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH)
... BMPR2: Bone morphogenetic protein receptor type II; Daam-1: Dishevelled-associated activator of morphogenesis 1; Dvl-2: Dishevelled-2; FFPE: Formalin-fixed and paraffin-embedded; FPAH: ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... of bone morphogenetic protein receptor type 2 (BMPR2), which is essential for embry- ogenesis and has been shown to play clinically-relevant roles in pulmonary vascular homeostasis and ...
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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
... Idiopathic pulmonary arterial hypertension (IPAH) is a rare disorder thought to develop following a genetic and/or environmental insult that triggers endothelial cell (EC) apoptosis, loss of distal vessels, and occlusive ...
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Organizing pneumonia in mice and men
... BMPs: bone morphogenetic proteins; BMPR1B: bone morphogenetic protein receptor type-1B; BO: bronchiolitis obliterans; BOOP: bronchiolitis obliterans organizing pneumonia; CCL2: ...
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Hemodynamic and genetic analysis in children with idiopathic, heritable, and congenital heart disease associated pulmonary arterial hypertension
... the bone morphogenetic protein receptor type II (BMPR2) gene on chromosome 2q33 were found in > 70-80% of adult PAH patients with familial history of disease ...
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The extracellular regulation of bone morphogenetic protein signaling
... from receptor-mediated endocytosis and degradation (Akiyama et ...block receptor-mediated endocytosis, one might expect equally strong inhibition of receptor-mediated ...reducing receptor ...
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Follistatin is a metastasis suppressor in a mouse model of HER2 positive breast cancer
... several bone morphogenetic protein (BMP) family members, albeit with lower affinity [42, ...BMP receptor, activin receptor-like kinase 2 (ALK2), can reduce metastatic spread of mammary ...
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Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes
... Fibrodysplasia Ossificans Progressiva (FOP) (OMIM #135100) is a rare, severely disabling disease character- ized by malformed big toes and progressive heterotopic ossification (HO) in muscles, tendons, and ligaments, and ...
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Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage
... 15: Bone morphogenetic growth protein-15; BMP-4: Bone morphogenetic growth protein-4; CCK-8: Cell counting kit-8; CM: conditioned medium; CTX: Cyclophosphamide; Cy: Chemotherapy; ...
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Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β
... BMP: Bone morphogenetic protein; CXCR4 : C-X-X motif receptor 4; CYP: Cytochrome P450; DKK: Dickkopf-related protein; dpMSC: Dental pulp-derived MSC; ECs: Endothelial cells; EGM: ...
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Genomic approaches to research in pulmonary hypertension
... Pulmonary hypertension (PH) refers to a spectrum of dis- eases where the pulmonary artery pressure is elevated. A new classification of PH has recently been proposed [1]. No cause can be elucidated in primary (or ...
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Blockade of bone morphogenetic protein signaling potentiates the pro inflammatory phenotype induced by interleukin 17 and tumor necrosis factor α combination in rheumatoid synoviocytes
... We next examined the effects of critical pro-inflammatory cytokines in RA, such as TNF-α and IL-17, on the ex- pression of the different components of the BMP sig- naling pathway. The culture of synoviocytes with IL-17 ...
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BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex
... investigated to our knowledge. The cytosolic part of BMPRII-LF contains 24 tyrosines; the majority of ty- rosines are located within the kinase domain, a few in the C-terminal tail and none in the juxtamembrane region ...
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A novel microcurrent dressing for wound healing in a rat skin defect model
... the protein concentration was determined using the bicinchoninic acid ...method. Protein extracts were diluted in loading buffer (Solarbio Science&Technol- ogy, China) and denatured for 10 min at 95 ...
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Molecular pathogenesis of pulmonary arterial hypertension
... The penetrance of heritable PAH is low: 80% of family members carrying BMPR2 mutations will never develop PAH (30). The pres- ence of a BMPR2 mutation is much lower (i.e., 6%–8%) in patients with PAH related to a ...
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