bone morphogenic protein
Original Article The effects of recombinant human bone morphogenic protein-2 and low-level laser ırradiation on synthetic graft healing in a rat bony defect model
... of bone morphogenic protein-2 (BMP-2) and low-level laser irradiation (LLLI) on the osseointegration of synthetic bone ...Synthetic bone grafts are safe alternatives to ...
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Curcumin Inhibits Prostate Cancer Bone Metastasis by Up Regulating Bone Morphogenic Protein 7 in Vivo
... of bone metastasis and hence, the TGF-β signaling pathway in tumor cells and its cross talk within the bone microenvironment present as attractive therapeutic targets ...the bone morphogenic ...
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Bone Morphogenic Protein 2 (rhBMP2) Loaded Silk Fibroin Scaffolds to Enhance the Osteoinductivity in Bone Tissue Engineering
... There is an increasing demand for formulations of silk fibroin (SF) scaffolds in biomedical applications. SF was crosslinked via glutaraldehyde with osteoinductive recombinant human bone morphogenic ...
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Oncogenic features of the bone morphogenic protein 7 (BMP7) in pheochromocytoma
... In human cancers, BMPs exhibit pro- or anti- carcinogenic functions depending on the cell/tissue type, dosage, and micro-environment [24]. Although the functional significance of BMP7 has been studied in several tumors, ...
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Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor β/bone morphogenic protein signalling
... OA bone in this study, which is consistent with increased osteoblast differentiation and activity in OA ...subchondral bone changes in a mouse joint instability OA model [78], suggesting a role for ...
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Tamoxifen and bone morphogenic protein-7 modulate fibrosis and inflammation in the peritoneal fibrosis model developed in uremic rats
... Additional file 1: Table S1. Average body weights and overall mortality rates of all groups. Table S2. Urinary volumes of all experimental groups. Table S3. Average peritoneal membrane thickness and α -SMA expression in ...
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Investigation of polymorphic variation in the growth differentiation factor-9 gene (GDF9) in New Zealand sheep breeds
... discovered the SNP of the Booroola locus, almost simultaneously. The SNP was located in Bone morphogenic protein (BMPR1B) (Souza, MacDougall, Campbell, McNeilly, & Baird, 2001; Wilson, et al., ...
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Molecular networks in skeletal muscle plasticity
... influencing protein synthesis and activating catabolic ...Smad protein complex. Myostatin also suppresses bone morphogenic protein signaling, this protein being a potent promoter ...
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Analysis of MiRNA-17 and MiRNA-146 Expression During Differentiation of Spermatogonial Stem Like Cells Derived from Mouse Bone Marrow Mesenchymal Stem Cells
... mouse bone marrow mesenchymal stem cells (BMSCs) through bone morphogenic protein 4 (BMP4) and retinoic acid (RA) ...expression, protein expression (Plzf, Stra8), and miRNA-17 and ...
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Fibroblast biology Effector signals released by the synovial fibroblast in arthritis
... Mesenchymal stem cells were isolated from the peripheral blood and synovial fluid of patients with inflammatory syn- ovitis. These cells displayed osteocyte and osteoclast morphology, and stained positive for tartrate ...
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Platelet lysate as a substitute for animal serum for the ex-vivo expansion of mesenchymal stem/stromal cells: present and future
... BM, bone marrow; BMP, bone morphogenic protein; CB, cord blood; CFU-F, fibroblastoid colony-forming unit; EGF, epidermal growth factor; FBS, fetal bovine serum; GMP, Good Manufacturing ...
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The role of heparan sulphate in the development of mouse embryoid bodies
... Abbreviations ASC Adult stem cell BM Basement membrane BMP Bone morphogenic protein CEE Columnar epiblast epithelium CRC Colorectal cancer DAPI%%%%%4',6FdiamidinoF2Fphenylindole DMEM Dul[r] ...
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The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma
... X protein; BCL-2: B-cell lymphoma 2; bHLH: Basic-helix-loop-helix family of proteins; BMP: Bone morphogenic protein; CGNP: Cerebellar granule neuron precursor; E1: Ubiquitin activating enzyme; ...
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rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP 7/Smad1/5/8 pathway
... Bone morphogenic protein (BMP)-7, a member of the TGF-β superfamily, has been reported to counter- act some of the profibrogenic actions of TGF-β1 ...
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Bone marrow mesenchymal stem cells in rheumatoid arthritis, spondyloarthritis, and ankylosing spondylitis: problems rather than solutions?
... In AS, some works concluded that the ossification of entheses might result from an enhancement of BM-MSC osteogenesis following IL-22 exposure alone (Fig. 1). In- deed, a combination of IFN-gamma and TNF with or without ...
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Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases
... and bone morpho- genic proteins. We recently found that bone morphogenic protein-2 (BMP-2), a ligand that promotes astrocytic dif- ferentiation, enhances the ability of BBM tumors to engraft ...
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Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review
... BMA, bone marrow aspirate; BMP, bone morphogenic protein; ECM, extracellular matrix; EGF, endothelial growth factor; FGF2, basic fibroblast growth factor; HA, hyaluronic acid; HUCPVC, human ...
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Tissue engineering in mandibular reconstruction: osteogenesis-inducing scaffolds
... Currently, the gold standard for aesthetic and functional reconstruction of critical mandibular defects is an autologous fibular flap; however, this carries risk of donor site morbidity, and is not a promising option in ...
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Breast cancer cells promote a notch dependent mesenchymal phenotype in endothelial cells participating to a pro tumoral niche
... Abbreviations BCCs: Breast cancer cells; BCSCs: Breast cancer stem cells; BMP: Bone morphogenic protein; CAFs: Cancer-associated fibroblasts; CM: Conditioned media; ECs E4-ECs: Endotheli[r] ...
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Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology
... construct bone defects that are caused by fractures, cancers, congenital abnormalities, and so ...as bone morphogenic protein (BMP), are used clinically to induce new bone for- mation, ...
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