Botulinum Neurotoxin Type A
Original Article Botulinum neurotoxin type A inhibits synaptic vesicle 2 expression in breast cancer cell lines
... of botulinum neurotoxins (BoNTs), which are highly poison- ous two-chain bacterial protein toxins ...[17]. Botulinum neurotoxin type A (BoNTA) and B (BoNTB) cause the disease denominated botu- ...
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Botulinum neurotoxin type A in the treatment of classical Trigeminal Neuralgia (BoTN): study protocol for a randomized controlled trial
... Botulinum neurotoxin type A (BT-A) is a potent neuro- toxin derived from Clostridium botulinum . It blocks the release of acetylcholine at the neuromuscular junction and has also been found to ...
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Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia
... BoNT-A Botulinum neurotoxin type A, BPS Bladder pain syndrome, CCH Chronic cervicogenic headache, CDH Chronic daily headache, CI Confidence interval, CM Chronic migraine, CNP Chronic neck pain, EM ...
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Original Article Effect of botulinum neurotoxin type A (BoNTA) on the morphology and viability of 3T3 murine fibroblasts
... BoNT inhibits the release of a neurotransmit- ter-acetylcholine-in motor nerve endings, thus blocking nerve function. This characteristic has been exploited in therapeutic applications to reduce muscle hyperactivity, ...
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Neutralizing antibodies to botulinum neurotoxin type A in aesthetic medicine: five case reports
... repeated botulinum toxin type A injections, it is important to determine the underlying ...to botulinum neurotoxins, including misplaced toxin, suboptimal dosing, administration of toxin that has ...
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An Ultrasensitive Gold Nanoparticle based Lateral Flow Test for the Detection of Active Botulinum Neurotoxin Type A
... timely botulinum antitoxin ...human-derived botulinum antitoxin has been recommended to administer as early as possible by some experts ...Clostridium botulinum lysis and subsequent BoNTs release ...
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A new treatment for focal dystonias: incobotulinumtoxinA (Xeomin<sup>®</sup>), a botulinum neurotoxin type A free from complexing proteins
... BoNT product that is free of complexing proteins. The necessity of complexing proteins for the effectiveness of botulinum toxin treatment has been challenged by preclinical and clinical studies with ...
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Modulation of inflammatory mediators in the trigeminal ganglion by botulinum neurotoxin type A: an organ culture study
... Methods: To induce inflammation, rat TGs were incubated for 24 hrs with either the mitogen MEK1/2 inhibitor U0126, BoNT-A or NaCl. After this the TGs were prepared for immunohistochemistry. Sections of the TG were then ...
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Comparison of botulinum neurotoxin type A formulations in Asia
... parallel with Xeomin using a sensitive sandwich ELISA with anti-150 kDa neurotoxin antisera raised in rabbit and guinea pigs. Coated microtiter plates were incubated with antisera diluted 1:1,000 in 100 mmol/L ...
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SIAXIPlacebo-controlled, randomized, double-blind study of incobotulinumtoxinA for sialorrhea
... However, botulinum neurotoxin type A (BoNT/A) had been effectively used to reduce saliva production in patients with sialorrhea since 1999, 11,12 and numerous studies had demonstrated the safety and ...
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Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells
... cells. Botulinum neurotoxin type A (BoNT/A), produced by a Clostridium bacterium carries a protease that selectively cleaves SNAP25 thereby blocking neuronal secretion for several months (Meunier et ...
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Pallidal neurostimulation versus botulinum toxin injections in the treatment of cervical dystonia: protocol of a randomized, sham-controlled trial (StimTox-CD)
... versus botulinum neurotoxin type ...a neurotoxin test injection, but are willing to undergo DBS surgery due to unsatisfactory symptom ...regular neurotoxin injections and undergoes a ...
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Design, expression, and testing of a bivalent subunit botulism vaccine for use in cattle
... of Botulinum Neurotoxin Type A: Regions Recognized by T Cells and Antibodies Against the Protective Hc Fragment (Residues 855-1296) of the ...
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Characterization and personalization of botulinum toxin type A therapy for upper limb tremor in Parkinson disease and Essential tremor patients using multi-sensor kinematic technology
... shown botulinum neurotoxin type A (BoNT-A) injections as a possible focal treatment for tremor, although finger and wrist extensor muscle weakness and dose-dependent limb weakness frequently ...
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Sectioned images and surface models of a cadaver head with reference to botulinum neurotoxin injection
... Background: The aim of this study is to elucidate the anatomical considerations with reference to botulinum neurotoxin type A (BTX) injection, on sectioned images and surface models, using Visible ...
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IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations
... of botulinum neurotoxin type A (BoNT/A) in facial aesthetics, there are no global or Russian guidelines on the optimal dose of incobotulinumtoxinA, free from complexing proteins, within specific ...
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Profile of Xeomin<sup>®</sup> (incobotulinumtoxinA) for the treatment of blepharospasm
... unique botulinum neurotoxin type A (BoNT/A) drug free of complexing proteins otherwise contained in all conventional BoNT/A drugs, was recently approved by US Food and Drug Administration for the ...
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Development of novel assays for botulinum type A and B neurotoxins based on their endopeptidase activities
... C. botulinum with the same sensitivity as that ob- served for the purified ...other botulinum neurotoxin serotypes, is produced in the form of a large protein complex in which the neurotoxin ...
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First Case of Type E Wound Botulism Diagnosed Using Real Time PCR
... the type B neurotoxin gene has previously been described by Lo ¨venklev et ...the neurotoxin genes of C. botulinum type E (accession numbers X62683, AB039264, AB040123, AB040125, ...
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Genomic Epidemiology of Clostridium botulinum Isolates from Temporally Related Cases of Infant Botulism in New South Wales, Australia
... eighth type was recently reported (H) (40, 41) but is still to be ...C. botulinum (groups I to IV) (42, 43) or less frequently by Clostridium butyri- cum or Clostridium baratii ...C. botulinum group ...
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