Brain Barriers
Progress in brain barriers and brain fluid research in 2017
... in brain barriers and brain fluids research are driven by technological ...classic brain endothe- lial markers, such models exhibited very high transen- dothelial electrical ...vivo ...
8
Current approaches to enhance CNS delivery of drugs across the brain barriers
... brain barriers. As the protective barrier of the CNS, the blood–brain barrier and the blood–cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper ...
17
Blood–brain-barriers in aging and in Alzheimer’s disease
... Peripheral inflammatory conditions may also trigger the barriers and modulate their response in aging and in CNS diseases. Of interest, whether sustained or repeated exposure to inflammation increases ...
9
High Blood Pressure Effects on the Brain Barriers and Choroid Plexus Secretion
... the brain barriers can also be studied by using Transthyretin (TTR) and S-100β: TTR is a protein involved in the transport of thyroid hor- mones in blood and CSF, and transthyretin is expressed in CSF as a ...
5
Abstracts from the 22nd International Symposium on Signal Transduction at the Blood–Brain Barriers
... Natural polyphenols of flavonoid-type (flavonols, flavones, flavanols, flavanones, anthocyanins and isoflavones) and non-flavonoid type (phenolic acids, lignans, stilbenoids) with their anti-oxidative and anti- ...
12
Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
... Activation of hypoxia inducible factor-1 (HIF-1) is crucial for cells to adapt to hypoxic/ischemic stresses. For decades, HIF-1 stroke research has mainly been limited to neurons with stabilization of HIF-1 sug- gested ...
23
The year in review: progress in brain barriers and brain fluid research in 2018
... Role of NVU/BBB changes in neurological conditions NVU/BBB functions are altered in many neurological conditions. There have been multiple reviews in 2018 outlining the current state of knowledge with regards to ...
12
Brain barriers and brain fluid research in 2016: advances, challenges and controversies
... Many neurological conditions are accompanied by BBB dysfunction (e.g. stroke, traumatic brain injury and brain neoplasms) with increased transfer of even proteins from blood to brain. There has ...
5
Fluids and barriers of the CNS: a historical viewpoint
... four barriers, there are studies describing the importance of the arachnoid barrier (at the level of the cerebral blood vessels on the outer sur- face of the brain in the arachnoid [4]), the blood-retinal ...
17
The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher
... various brain regions of substrates for an oligopeptide transporter PEPT2 (SLC15A2) following their intra- cerebroventricular ...the brain exposure to CSF-borne peptides and peptide-like drugs by ...
18
Transfer mechanisms for low molecular weight lipid insoluble molecules into the developing brain
... The brain barriers can be divided into four principal interfaces: 1 the endothelium of the cerebral blood vessels blood-brain barrier, 2 the epithelium of choroid plexus tissue in the br[r] ...
218
A new look at cerebrospinal fluid circulation
... the brain tissue itself ...of brain interstitial fluid (ISF). The ISF secreted at the blood–brain barrier is coupled with shifts of extracellular fluid between brain and CSF, eventually ...
16
Anaplasma phagocytophilum-Borrelia burgdorferi Coinfection Enhances Chemokine, Cytokine, and Matrix Metalloprotease Expression by Human Brain Microvascular Endothelial Cells
... human brain microvascular endothelial cells of the blood-brain barrier is facilitated by endothelial cell-derived matrix metalloproteases ...of brain microvascular barriers during ...
5
Electrolytic lesions within central complex neuropils of the cockroach brain affect negotiation of barriers
... Animals must negotiate obstacles in their path in order to successfully function within natural environments. These actions require transitions from walking to other behaviors, many of which are more involved than simple ...
14
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
... the brain: MCT1, MCT2, MCT4 and MTC8, which are selectively present in distinct cell types and membrane domains ...the brain ISF it is above 3 mM ...the brain ISF to the blood, to avoid its ...
25
An analysis of the development and implementation of a smartphone application for the delivery of antimicrobial prescribing policy: lessons learnt
... identified barriers and potential unwanted consequences at the individual and organizational levels of implementing a mobile application for antimicrobial prescribing, and provide potential solutions to addressing ...
9
Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms
... Due to their unique physicochemical properties, graphene-family nanomaterials (GFNs) are widely used in many fields, especially in biomedical applications. Currently, many studies have investigated the biocompatibility ...
24
Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics
... semi-PBPK brain rat model has been developed [34] followed by the full-PBPK brain rat model ...human brain on the basis of solely physicochemical properties of compounds ...
13
Targeted Nanoparticle Delivery of Therapeutics Across the Blood-Brain and Blood-Tumor Barriers to Breast Cancer Brain Metastases
... the brain and therapeutics that are effective systemically, but that do not penetrate the brain creates the opportunity for brain metastatic cancers to become an even greater clinical challenge, ...
172
Barriers of the developing brain : in vivo and in vitro studies
... The fetal, plasma protein fetuin has been shown to be present within cells in the developing brains of many different species: sheep Saunders et al, 1992; Dziegielewska et al, 1993; M011[r] ...
206