Brain–blood barrier breakdown
Mouse Adenovirus Type 1-Induced Breakdown of the Blood-Brain Barrier
... cause breakdown of the BBB by disrupting tight junction formation and altering adhesion molecule expression on brain endothe- lial ...BBB breakdown in mice (65, 67, ...induce breakdown of the ...
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Viral Pathogen Associated Molecular Patterns Regulate Blood Brain Barrier Integrity via Competing Innate Cytokine Signals
... enhance barrier function over baseline conditions and to rescue Th1 cytokine-mediated barrier dysregulation, suggesting that CNS type I IFN responses may be able to reverse the BBB perme- ability caused by ...
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Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia
... the brain and capable of responding rapidly to produce an array of chemokines and cytokines, such as eotaxin, IL-8 (in rodents), which promote recruitment, vascular adhesion, diapadesis and activation of ...
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Beyond blood brain barrier breakdown – in vivodetection of occult neuroinflammatory foci by magnetic nanoparticles in high field MRI
... PBS. Brain and spinal cord were removed and postfixed in 4% ...entire brain were stained either by standard hematoxylin and eosin (H&E) proce- dure to detect cellular inflammation or by Prussian Blue ...
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Sustained pharmacological inhibition of δPKC protects against hypertensive encephalopathy through prevention of blood brain barrier breakdown in rats
... Hypertensive encephalopathy is a potentially fatal condition associated with cerebral edema and the breakdown of the blood-brain barrier (BBB). The molecular pathways leading to this ...
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Angiogenesis and Blood Brain Barrier Breakdown Modulate CT Contrast Enhancement: An Experimental Study in a Rabbit Brain Tumor Model
... Normal capillaries of the brain maintain the integrity of the BBB [35], but the blood vessels of experimental [36] and human [37] brain tumors are structurally altered and have an increa[r] ...
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Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia
... (arrow) remained detectable while an extravasation of FITC albumin was not observed. 1 h (1 h) after ischemia induction, affected vessels showed edematous endo- thelial cells (score 1) or cells, which lost the ...
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Blood-brain Barrier Remodeling during Brain Metastasis Formation
... BBB breakdown and increased brain colonization by metastasizing breast cancer cells ...perimental brain metastasis ...cancer brain metastasis, since tumor cells that prefera- bly metastasize ...
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Calcium dependent blood brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke
... Ischemic stroke represents one of the most frequent causes of death and leading causes of disability worldwide (1). Thrombolytic or mechanical removal of the occlusion is the only therapeutic option (2). In 11% of the ...
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Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study
... profound breakdown of the BBB was first demonstrated in a rat model of severe insulin- induced hypoglycemia ...the brain site it interacts with the endothelial cells forming the BBB and inhibits their ...
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Inhibition of complement C5a prevents breakdown of the blood brain barrier and pituitary dysfunction in experimental sepsis
... whole blood was collected into syringes containing antico- agulant citrate dextrose (Baxter, Deerfield, IL, USA) in a 9:1 ratio by puncture of the inferior vena cava 24 hours after CLP or sham ...
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Predicting Breakdown of the Blood Brain Barrier in Multiple Sclerosis without Contrast Agents
... the brain and dividing by their SD; thus, normalization was carried out at the scan level, rather than the subject or population ...entire brain (see On-line Appendix for ...
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Plasma and cerebrospinal fluid interleukin-1β during lipopolysaccharide-induced systemic inflammation in ewes implanted or not with slow-release melatonin
... the brain is restricted by brain barriers: blood-brain bar- rier (BBB) located in cerebromicrovascular endothelial cells and blood-cerebrospinal fluid barrier (BCSFB) lo- cated ...
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Intracranial Applications of MR Imaging–Guided Focused Ultrasound
... Disclosures: Dheeraj Gandhi—UNRELATED: Expert Testimony: Occasionally ( ⬍ 1 year) provided expert testimony on medicolegal cases related to cerebrovascular disease; Royalties: Cambridge Press. RELATED: Grants/Grants ...
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NIH workshop report on the trans-agency blood–brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface
... Dr. William Banks emphasized that the BBB acts as a complex interface regulating the exchange of nutrients, informational molecules, and other substances between the CNS and blood. The properties of this interface ...
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Online Full Text
... he blood-brain barrier (BBB) presents a real challenge to the pharmaceutical industry. The BBB is very effective screener of diverse kinds of bacterial infections. Unfortunately, this functionality ...
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Bilirubin Beyond the Blood-Brain Barrier
... versible clinical bilirubin-induced neurotoxicity represents a more attractive criterion than serum bilirubin concentration to perform an invasive preventive therapy such as exchange tra[r] ...
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Disruption of the hippocampal and hypothalamic blood–brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate
... Non-fasted blood glucose was meas- ured weekly using the AlphaTRAK2 blood glucometer (Zoetis, Parsippany, New Jersey, USA) from the tail ...non-fasted blood glucose was ...the brain and retina ...
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Super Antibiotics, Part II Hyperforin, Mass Spectroscopy (MS) and Gas Chromatography Mass Spectrometry (GC MS), Evidence of Permeability of the Blood Testis Barrier (BTB) and the Blood Brain Barrier (BBB) to Hyperforin
... the brain, testis, heart, lungs, kidneys, liver, and blood) were surgically removed under anesthesia, and after suitable preparation, extraction, and clean-up, were ana- lyzed by gas chromatography-mass ...
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Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
... related blood-spinal cord barrier (BSCB) in other animal models of neurological disease, including stroke [56, 57], intracerebral hemorrhage [58], intracerebral LPS injection [59], MPTP toxicity [60] and ...
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